通过水代替有机溶剂来提纯2-丙基-4,5-1 H-咪唑二羧酸二乙酯和4-(1-羟基-1-甲基乙基)-2-丙基-1 H-咪唑-5-羧酸乙酯的新方法,使得改进工艺更加绿色简便。采用1 H NMR、13 C NMR、IR、MS谱图对反应后的产品和未知杂质进行结构鉴定,确证为...通过水代替有机溶剂来提纯2-丙基-4,5-1 H-咪唑二羧酸二乙酯和4-(1-羟基-1-甲基乙基)-2-丙基-1 H-咪唑-5-羧酸乙酯的新方法,使得改进工艺更加绿色简便。采用1 H NMR、13 C NMR、IR、MS谱图对反应后的产品和未知杂质进行结构鉴定,确证为一水合4-(1-羟基-1-甲基乙基)-2-丙基-1 H-咪唑-5-羧酸乙酯和4-乙酰基-2-丙基-1 H-咪唑-5-羧酸乙酯。对反应的可能机理进行初步研究。展开更多
A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)...A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.展开更多
文摘通过水代替有机溶剂来提纯2-丙基-4,5-1 H-咪唑二羧酸二乙酯和4-(1-羟基-1-甲基乙基)-2-丙基-1 H-咪唑-5-羧酸乙酯的新方法,使得改进工艺更加绿色简便。采用1 H NMR、13 C NMR、IR、MS谱图对反应后的产品和未知杂质进行结构鉴定,确证为一水合4-(1-羟基-1-甲基乙基)-2-丙基-1 H-咪唑-5-羧酸乙酯和4-乙酰基-2-丙基-1 H-咪唑-5-羧酸乙酯。对反应的可能机理进行初步研究。
文摘A compound ethyl(5S,6R)-2-(4-methylphenyl)-6-[(1R)-tert-butyldimethylsilyloxyethy]-penem-3-carboxylate was synthesized through displacement,acylation and Wittig cyclization reaction of optically active material(3R,4R)-3-[(1R)-tert-butyldimethylsilyloxyethyl]-4-acetoxy-2-azetidi-none(4AA)upon thionocarboxlic acid.The intermediates and the target product were characterized by 1HNMR,IR,elementary analysis and MS.
