A route of synthesis of a novel macrocyclic sulfonamide peptidomimetics \%via\% ring closing metathesis(RCM) has been designed. Allyl glutaric anhydride has been synthesized from commercially available diethyl allylma...A route of synthesis of a novel macrocyclic sulfonamide peptidomimetics \%via\% ring closing metathesis(RCM) has been designed. Allyl glutaric anhydride has been synthesized from commercially available diethyl allylmanolate and \%tert\% butyl acrylate by the Michael reaction and hydrolysis followed by decarboxylation and dehydration. Then, allyl hydrogen 2\|allylglutarate, a precursor for RCM, has been prepared. The synthesis of N \|allyl\|2\|ethoxycarbonyl\|2\|aminoethylsulfonyl amide, another precursor, has been accomplished from cystine.展开更多
文摘A route of synthesis of a novel macrocyclic sulfonamide peptidomimetics \%via\% ring closing metathesis(RCM) has been designed. Allyl glutaric anhydride has been synthesized from commercially available diethyl allylmanolate and \%tert\% butyl acrylate by the Michael reaction and hydrolysis followed by decarboxylation and dehydration. Then, allyl hydrogen 2\|allylglutarate, a precursor for RCM, has been prepared. The synthesis of N \|allyl\|2\|ethoxycarbonyl\|2\|aminoethylsulfonyl amide, another precursor, has been accomplished from cystine.
