The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-...The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.展开更多
The synthesis of a new reagent 1-azobenzene-3-(5-nitro-2-pyridyl)-triazene(ABNPDT) and its colour reaction with cadimum were reported. At pH=10.40, in the presence of Triton X-100, ABNPDT react with cadimum to form a ...The synthesis of a new reagent 1-azobenzene-3-(5-nitro-2-pyridyl)-triazene(ABNPDT) and its colour reaction with cadimum were reported. At pH=10.40, in the presence of Triton X-100, ABNPDT react with cadimum to form a red Complex. The maximum absorption of reagent and complex are at 430nm and 520NM respectively. The molar absorpitivity is 2.0710 5L·mol -1 ·cm -1 . Berr’s law can be applied in the rang of 0～12μg/25ml. This method was used to determine tarce cadmium in water with satisfactory results.展开更多
研究了1-丁基-3-甲基咪唑六氟磷酸盐[BMIM]PF6/缓冲液两相体系中,热带假丝酵母104细胞催化3,5-双三氟甲基苯乙酮不对称还原制备(S)-1-[3,5-双(三氟甲基)苯基]乙醇的反应过程。通过考察影响生物还原反应的主要因素,如离子液体浓度、辅助...研究了1-丁基-3-甲基咪唑六氟磷酸盐[BMIM]PF6/缓冲液两相体系中,热带假丝酵母104细胞催化3,5-双三氟甲基苯乙酮不对称还原制备(S)-1-[3,5-双(三氟甲基)苯基]乙醇的反应过程。通过考察影响生物还原反应的主要因素,如离子液体浓度、辅助底物种类和浓度、底物浓度、菌体浓度和转化时间等,发现上述因素对产率影响较大,但基本不影响产物手性醇的光学纯度。优化得到的较佳还原反应条件为:[BMIM]PF6体积分数5%,辅助底物为60 g L 1异丙醇,底物3,5-双三氟甲基苯乙酮浓度70 mmol L 1,菌体浓度350 g L 1,转化时间24 h。在优化条件下,产率达82.5%,产物(S)-1-[3,5-双(三氟甲基)苯基]乙醇的对映体过量值大于99.9%。与水相转化相比,采用[BMIM]PF6/缓冲液两相体系进行3,5-双三氟甲基苯乙酮的生物不对称还原可有效提高底物浓度和产率,且反应时间缩短了6 h。展开更多
The synthesis of an new photochromical compound,1,3,3 trimethyl 6′ (1 piperidinyl) spiro[2h indole 2,3′ [3H]pyridobenzoxazine (SP3),and an improved way for the synthesis of 6 hydroxyquinoline were descrided.The abso...The synthesis of an new photochromical compound,1,3,3 trimethyl 6′ (1 piperidinyl) spiro[2h indole 2,3′ [3H]pyridobenzoxazine (SP3),and an improved way for the synthesis of 6 hydroxyquinoline were descrided.The absorption spectrum of the colored metastable form SP3 shows prominent absorption peak at 560nm at 60℃?展开更多
文摘The fused triazole derivatives,which is an important inhibitors of the dipeptidyl peptidase-Ⅳ enzyme(DPP-Ⅳ),can be used for the treatment or prevention of type 2 diabetes.A new fused triazole derivatives of 3-oxo-3-[3-trifluoromethyl-5,6-dihydro[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-phenylpropan-1-amine was synthesized from 2-chloropyrazine and benzaldehyde by hydrazinolysis,trifluoroacetylation,cyclization,hydrogenation,condensation and deprotection reaction.The structures of the compound and its intermediates were determined by IR,NMR,and MS.
文摘The synthesis of a new reagent 1-azobenzene-3-(5-nitro-2-pyridyl)-triazene(ABNPDT) and its colour reaction with cadimum were reported. At pH=10.40, in the presence of Triton X-100, ABNPDT react with cadimum to form a red Complex. The maximum absorption of reagent and complex are at 430nm and 520NM respectively. The molar absorpitivity is 2.0710 5L·mol -1 ·cm -1 . Berr’s law can be applied in the rang of 0～12μg/25ml. This method was used to determine tarce cadmium in water with satisfactory results.
文摘研究了1-丁基-3-甲基咪唑六氟磷酸盐[BMIM]PF6/缓冲液两相体系中,热带假丝酵母104细胞催化3,5-双三氟甲基苯乙酮不对称还原制备(S)-1-[3,5-双(三氟甲基)苯基]乙醇的反应过程。通过考察影响生物还原反应的主要因素,如离子液体浓度、辅助底物种类和浓度、底物浓度、菌体浓度和转化时间等,发现上述因素对产率影响较大,但基本不影响产物手性醇的光学纯度。优化得到的较佳还原反应条件为:[BMIM]PF6体积分数5%,辅助底物为60 g L 1异丙醇,底物3,5-双三氟甲基苯乙酮浓度70 mmol L 1,菌体浓度350 g L 1,转化时间24 h。在优化条件下,产率达82.5%,产物(S)-1-[3,5-双(三氟甲基)苯基]乙醇的对映体过量值大于99.9%。与水相转化相比,采用[BMIM]PF6/缓冲液两相体系进行3,5-双三氟甲基苯乙酮的生物不对称还原可有效提高底物浓度和产率,且反应时间缩短了6 h。
文摘The synthesis of an new photochromical compound,1,3,3 trimethyl 6′ (1 piperidinyl) spiro[2h indole 2,3′ [3H]pyridobenzoxazine (SP3),and an improved way for the synthesis of 6 hydroxyquinoline were descrided.The absorption spectrum of the colored metastable form SP3 shows prominent absorption peak at 560nm at 60℃?
