The most softwares for protein-protein docking are regarded as two proteins being rigid, and take no account of the flexibility of proteins, which causes conformation variety of the interface because of interaction of...The most softwares for protein-protein docking are regarded as two proteins being rigid, and take no account of the flexibility of proteins, which causes conformation variety of the interface because of interaction of the interface amino acids. On the premise of the rigidity of protein-protein docking, by the method of molecular dynamic simulation, we search the protein-protein interface conformations of the complexes which grounded on the rigid docking. Since the interaction of the amino acid was taken into account, to a certain extent, the complex conformations are more perfect.展开更多
目的探讨Borealin在口腔鳞状上皮细胞癌(oral squamous cell carcinoma,OSCC)中的表达及与Ki-67增殖指数的关系。方法采用免疫组化LSAB法检测20例正常口腔黏膜组织和111例手术切除OSCC组织中Borealin及Ki-67的表达,分析其与OSCC临床病...目的探讨Borealin在口腔鳞状上皮细胞癌(oral squamous cell carcinoma,OSCC)中的表达及与Ki-67增殖指数的关系。方法采用免疫组化LSAB法检测20例正常口腔黏膜组织和111例手术切除OSCC组织中Borealin及Ki-67的表达,分析其与OSCC临床病理特征的关系。结果 Borealin在OSCC中高表达(52/111),在正常口腔黏膜中低表达(0/20),差异有统计学意义( P <0.01);Borealin在OSCC中的表达与肿瘤分化程度、淋巴结转移密切相关( P <0.05);Borealin与Ki-67的表达具有相关性( P <0.01)。结论 Borealin表达对判断OSCC的增殖、转移及恶性程度有重要意义,有望成为OSCC新的诊断标志物和治疗靶点。展开更多
文摘The most softwares for protein-protein docking are regarded as two proteins being rigid, and take no account of the flexibility of proteins, which causes conformation variety of the interface because of interaction of the interface amino acids. On the premise of the rigidity of protein-protein docking, by the method of molecular dynamic simulation, we search the protein-protein interface conformations of the complexes which grounded on the rigid docking. Since the interaction of the amino acid was taken into account, to a certain extent, the complex conformations are more perfect.
文摘目的探讨Borealin在口腔鳞状上皮细胞癌(oral squamous cell carcinoma,OSCC)中的表达及与Ki-67增殖指数的关系。方法采用免疫组化LSAB法检测20例正常口腔黏膜组织和111例手术切除OSCC组织中Borealin及Ki-67的表达,分析其与OSCC临床病理特征的关系。结果 Borealin在OSCC中高表达(52/111),在正常口腔黏膜中低表达(0/20),差异有统计学意义( P <0.01);Borealin在OSCC中的表达与肿瘤分化程度、淋巴结转移密切相关( P <0.05);Borealin与Ki-67的表达具有相关性( P <0.01)。结论 Borealin表达对判断OSCC的增殖、转移及恶性程度有重要意义,有望成为OSCC新的诊断标志物和治疗靶点。
