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促进伤口愈合的蜕皮甾酮乳膏的制备及量效分析 被引量:7
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作者 郑高云 吴旭 +2 位作者 李钰珑 张军花 王武军 《南方医科大学学报》 CAS CSCD 北大核心 2008年第5期828-831,共4页
目的研究蜕皮甾酮乳膏制剂的制备方法及其对实验性兔创伤模型促愈作用的量效分析,从而得出蜕皮甾酮乳膏促愈的最佳有效浓度。方法取一定量的乳膏基质,将其分别配制为0.625%、1.25%、2.5%、5%四种浓度的蜕皮甾酮乳膏。然后将9只体质量相... 目的研究蜕皮甾酮乳膏制剂的制备方法及其对实验性兔创伤模型促愈作用的量效分析,从而得出蜕皮甾酮乳膏促愈的最佳有效浓度。方法取一定量的乳膏基质,将其分别配制为0.625%、1.25%、2.5%、5%四种浓度的蜕皮甾酮乳膏。然后将9只体质量相近的新西兰兔制备成全皮层缺损的创伤动物模型,每只兔5个背部创面,分别敷以空白乳膏基质及四种浓度的蜕皮甾酮乳膏。其中8只兔,分别于造模后4、8、12d,拍摄愈合后的创面,统计其面积,同时计算出各个创面的伤口愈合率;另外1只兔,分别于造模后4、8、12d取其创面组织行病理学观察。结果伤口愈合率的统计学分析表明:蜕皮甾酮乳膏有明显的促进伤口愈合作用(P<0.01),最佳有效浓度为2.5%。病理学观察显示:2.5%蜕皮甾酮乳膏组创面较其他四组肉芽组织形成明显,上皮细胞、内皮细胞及成纤维细胞增生较多。结论蜕皮甾酮乳膏对实验性兔创伤缺损模型有明显促愈作用,其中以2.5%蜕皮甾酮乳膏促愈效果最佳,为临床促愈用药的筛选提供新思路。 展开更多
关键词 蜕皮甾酮 乳膏 量效分析 伤口愈合
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螺旋藻(Spirulina maxima)对降低高血脂大鼠血清甘油三酯浓度的量效分析 被引量:14
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作者 杨翔 何舒宁 +1 位作者 曾令柯 黄诚 《南京大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第2期182-186,共5页
以高脂饲料造型高血脂大鼠 ,饲喂不同剂量的螺旋藻饲料 ,建立血清甘油三酯值(TG)随时间 (t)变化的函数 ,通过求解其降脂极限临界值 ,推算出使高血脂大鼠达到健康标准的剂量组区间为 4 5 0mg/kg≤TG≤ 810mg/kg ,相应的理论服用期为 13.... 以高脂饲料造型高血脂大鼠 ,饲喂不同剂量的螺旋藻饲料 ,建立血清甘油三酯值(TG)随时间 (t)变化的函数 ,通过求解其降脂极限临界值 ,推算出使高血脂大鼠达到健康标准的剂量组区间为 4 5 0mg/kg≤TG≤ 810mg/kg ,相应的理论服用期为 13.6周≤t≤ 195 5周 ;利用求得的理论值与对应的剂量建立量效函数关系 ,精确求解出最低有效剂量临界值为 377.4mg/kg . 展开更多
关键词 大鼠 量效分析 螺旋藻 高血脂 血清甘油三酯 函数 保健食品 降血脂功能
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Investigation of floor heating with thermal storage 被引量:2
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作者 林真国 张素云 +1 位作者 付祥钊 王勇 《Journal of Central South University of Technology》 EI 2006年第4期399-403,共5页
Based on experimental data, the energy storage performances of floor radiant heating system were investigated. The decrease of indoor air temperature after the stopping of floor heating was compared with that of fan-c... Based on experimental data, the energy storage performances of floor radiant heating system were investigated. The decrease of indoor air temperature after the stopping of floor heating was compared with that of fan-coil heating system. The increase of indoor air temperature after the stopping of floor cooling system was analyzed. The results show that the floor heating system has good thermal storage performance, which can be used to a night-running model to obtain the energy-saving benefits efficient and economic running cost, and still can be used for “shifting peak load to off-peak” macroscopically. 展开更多
关键词 energy efficiency floor heatin energy storage shiftin peak load to off-peak
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Chromatographic fingerprint analysis of Fructus Aurantii Immaturus by HPLC-DAD and chemometric methods 被引量:4
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作者 徐小娜 蒋军辉 +3 位作者 梁逸曾 李晓如 易伦朝 成金乐 《Journal of Central South University》 SCIE EI CAS 2011年第2期353-360,共8页
An efficient method for quality control of Fructus Aurantii Immaturus (FAI),a famous traditional Chinese medicine (TCM) was established. A simple and reliable high-performance liquid chromatography-photodiode array de... An efficient method for quality control of Fructus Aurantii Immaturus (FAI),a famous traditional Chinese medicine (TCM) was established. A simple and reliable high-performance liquid chromatography-photodiode array detector (HPLC-DAD) procedure coupled with chemometric methods was developed for fingerprint analysis,qualitative analysis and quantitative determination of this herb. In qualitative and quantitative analyses,heuristic evolving latent projection (HELP) method was employed to resolve the overlapping peaks of the tested samples. Two bioactive components,namely hesperidin and naringin,are confirmed and determined,together with four flavonoids compounds tentatively identified including two new ones. From fingerprint analysis,the fingerprint data were processed with correlation coefficients for quantitative expression of their similarity and dissimilarity. The developed method based on an integration of chromatographic fingerprint and quantitative analysis is scientific,and the obtained results can be applied to the quality control of herb medicine. 展开更多
关键词 FINGERPRINT quality control Fructus Aurantii Immaturus high-performance liquid chromatography heuristic evolvinglatent projection method HESPERIDIN NARINGIN
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Time-variant reliability analysis of three-dimensional slopes based on Support Vector Machine method 被引量:4
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作者 陈昌富 肖治宇 张根宝 《Journal of Central South University》 SCIE EI CAS 2011年第6期2108-2114,共7页
In the reliability analysis of slope, the performance functions derived from the most available stability analysis procedures of slopes are usually implicit and cannot be solved by first-order second-moment approach. ... In the reliability analysis of slope, the performance functions derived from the most available stability analysis procedures of slopes are usually implicit and cannot be solved by first-order second-moment approach. A new reliability analysis approach was presented based on three-dimensional Morgenstem-Price method to investigate three-dimensional effect of landslide in stability analyses. To obtain the reliability index, Support Vector Machine (SVM) was applied to approximate the performance function. The time-consuming of this approach is only 0.028% of that using Monte-Carlo method at the same computation accuracy. Also, the influence of time effect of shearing strength parameters of slope soils on the long-term reliability of three-dimensional slopes was investigated by this new approach. It is found that the reliability index of the slope would decrease by 52.54% and the failure probability would increase from 0.000 705% to 1.966%. In the end, the impact of variation coefficients of c andfon reliability index of slopes was taken into discussion and the changing trend was observed. 展开更多
关键词 slope engineering Morgenstern-Price method three dimension Support Vector Machine time-variant reliability
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