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模型辅助抗体连续捕获过程表征和关键影响因素分析
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作者 贾思宁 孙艳娜 +3 位作者 高栋 王海彬 姚善泾 林东强 《高校化学工程学报》 EI CAS CSCD 北大核心 2024年第5期752-761,共10页
针对双柱连续流层析CaptureSMB连续捕获过程,提出了模型辅助过程表征方法。首先,比较了传统实验设计方法(DoE)和模型辅助方法,对6个中高风险参数进行了表征。结果表明,传统DoE方法无法准确表征参数对过程性能的影响,而模型辅助方法可排... 针对双柱连续流层析CaptureSMB连续捕获过程,提出了模型辅助过程表征方法。首先,比较了传统实验设计方法(DoE)和模型辅助方法,对6个中高风险参数进行了表征。结果表明,传统DoE方法无法准确表征参数对过程性能的影响,而模型辅助方法可排除无效操作点且考察范围更广。其次,通过模型确定了连接上样流速、连接上样时间和断开上样流速的参数范围,预测了最大过程产率操作点,进一步通过蒙特卡罗模拟和评估操作点的稳健性,得到最优的过程产率操作点。实验结果表明,模型辅助方法准确可靠,节约了时间和材料成本,可为连续捕获过程表征与优化提供指导,促进连续制造的工业应用。 展开更多
关键词 单克隆抗体 连续捕获 层析模型 过程表征 过程优化
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Unifying the Software Process Spectrum 被引量:5
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作者 Mingshu Li Barry W. Boehm Leon J. Osterweil 《软件学报》 EI CSCD 北大核心 2006年第4期649-657,共9页
Software Process Workshop (SPW 2005) was held in Beijing on May 25-27, 2005. This paper introduces the motivation of organizing such a workshop, as well as its theme and paper gathering and review; and summarizes the ... Software Process Workshop (SPW 2005) was held in Beijing on May 25-27, 2005. This paper introduces the motivation of organizing such a workshop, as well as its theme and paper gathering and review; and summarizes the main content and insights of 11 keynote speeches, 30 regular papers in five sessions of “Process Content”, “Process Tools and Metrics”, “Process Management”, “Process Representation and Analysis”, and “Experience Reports”, 8 software development support tools demonstration, and the ending panel “Where Are We Now? Where Should We Go Next?”. 展开更多
关键词 软件处理 微处理 宏处理 过程表征
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探索计算机精确计算在高中化学研究中的应用——基于“Wolfram Mathematica”平台 被引量:12
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作者 吴文中 《化学教学》 CAS 北大核心 2018年第5期92-97,共6页
通过分析银氨溶液等复杂溶液体系中各种粒子之间量的关系,基于Mathematica计算机辅助,直观形象地表征其化学过程;精确描述高中阶段一些常见的化学实验过程。介绍Mathematica计算机辅助计算的技巧以及计算模型建立方法,挖掘精确计算... 通过分析银氨溶液等复杂溶液体系中各种粒子之间量的关系,基于Mathematica计算机辅助,直观形象地表征其化学过程;精确描述高中阶段一些常见的化学实验过程。介绍Mathematica计算机辅助计算的技巧以及计算模型建立方法,挖掘精确计算背后不易觉察的“化学现象”。 展开更多
关键词 MATHEMATICA软件 高中化学 精确计算 表征化学过程
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Characterization of semi-coke generated by coal-based direct reduction process of siderite
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作者 朱德庆 罗艳红 +1 位作者 潘建 周仙霖 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第8期2914-2921,共8页
Solid wastes derived from metallurgical industries pose a significant threat to environment. The utilization and disposal of these solid wastes are the major concern in the world. Semi-coke generated in coal-based dir... Solid wastes derived from metallurgical industries pose a significant threat to environment. The utilization and disposal of these solid wastes are the major concern in the world. Semi-coke generated in coal-based direct reduction process of iron ore is a by-product and its suitable utilization is not available so far. In order to handle it properly, the characteristics of this by-product were comprehensively investigated. A series of analysis methods were used to demonstrate its mineral compositions, petrography and physico-chemical properties. The results reveal that the semi-coke has poor washability. The fixed carbon content of semi-coke reaches 76.11% and the gross calorific value is 28.10 MJ/kg, both of which are similar to those of traditional sinter coke breeze. Also, semi-coke ash possesses lower content of SiO2, Al2O3, S and higher content of CaO and MgO, which could improve the strength of sinter ore when partially substituting for coke breeze in sintering. Semi-coke features well-development porous structure and higher reaction activity, which predicts that the sintering speed could be elevated to some extent when employing it as a partial replacement of coke breeze, so the studies further suggest that the potential adverse effect of the high reactivity on sintering process could be weakened by adequately coarsening the semi-coke's particle size. 展开更多
关键词 SEMI-COKE coal-based direct reduction non-magnetic product sinter fuel
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Characterization of hot deformation behavior of Al-Zn-Mg-Mn-Zr alloy during compression at elevated temperature 被引量:4
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作者 YAN Jie 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第3期515-520,共6页
The hot deformation behavior of Al-6.2Zn-0.70Mg-0.30Mn-0.17 Zr alloy and its microstructural evolution were investigated by isothermal compression test in the deformation temperature range between 623 and 773 K and th... The hot deformation behavior of Al-6.2Zn-0.70Mg-0.30Mn-0.17 Zr alloy and its microstructural evolution were investigated by isothermal compression test in the deformation temperature range between 623 and 773 K and the strain rate range between 0.01 and 20 s^(-1).The results show that the flow stress decreased with decreasing strain rate and increasing deformation temperature.At low deformation temperature(≤673 K) and high strain rate(≥1 s^(-1)),the main flow softening was caused by dynamic recovery;conversely,at higher deformation temperature and lower strain rate,the main flow softening was caused by dynamic recrystallization.Moreover,the slipping mechanism transformed from dislocation glide to grain boundary sliding with increasing the deformation temperature and decreasing the strain rate.According to TEM observation,numerous Al_3Zr particles precipitated in matrix,which could effectively inhibit the dynamic recrystallization of the alloy.Based on the processing map,the optimum processing conditions for experimental alloy were in deformation temperature range from 730 K to 773 K and strain rate range from 0.033 s^(-1) to 0.18 s^(-1) with the maximum efficiency of 39%. 展开更多
关键词 aluminum alloy hot deformation TEM dynamic recrystallization processing map
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Preparation and characterization of Mo-Cu nanocomposite powders by chemical liquid reduction process
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作者 李翼 王德志 孙翱魁 《Journal of Central South University》 SCIE EI CAS 2013年第3期587-591,共5页
A novel chemical liquid reduction process was employed to prepare nanosized Mo-Cu powders. The precipitates were first obtained by adding ammonium heptamolybdate ((NH4)6Mo7024·4H2O) solution into excess hydra... A novel chemical liquid reduction process was employed to prepare nanosized Mo-Cu powders. The precipitates were first obtained by adding ammonium heptamolybdate ((NH4)6Mo7024·4H2O) solution into excess hydrazine hydrate solution, and then mixed the copper chloride solution. The precipitates were subsequently washed, dried, followed by reducing in H2 atmosphere to convert into Mo-Cu composite powders. The composition, morphology and particle size of the Mo-Cu composite powders were characterized by the XRD, SEM and TEM. The effects of the chemical reaction temperature and the magnetic stirring on the morphology of the Mo-Cu powders were also studied. The results show that Mo-Cu powders produced by the chemical liquid reduction process are nearly spherical shape and dispersive distribution state, with particle size ranging from 50 to 100 nm. The chemical reaction temperature and magnetic stirring will change the particle feature of the powders. Because of the Cu3M0209, the reduction process in H2 is the one-stage reduction from the precipitates to the Mo-Cu composite powders. 展开更多
关键词 Mo-Cu powder NANOCOMPOSITE liquid reduction MICROSTRUCTURE
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