Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathway...Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR-γ ligands significantly improve myocardial functional recovery and prevent ischemia-reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR-γ ligands,we know today that the therapeutic effects of PPAR-γ ligands reach far beyond their use as insulin-sensitizers,as many of these agents exert beneficial effects in the conditions associated with ischemia-reperfusion and inflammation.展开更多
In present review,the history of microangiopathy discovery and it’s modern concept were introduced and the pathophysiological changes of some vital organs in diabetes were analyzed.The roles of oxidation stress,distu...In present review,the history of microangiopathy discovery and it’s modern concept were introduced and the pathophysiological changes of some vital organs in diabetes were analyzed.The roles of oxidation stress,distur-bances of microvascular functions,microvascular endothelial cell damage,PKC and PPARγ in pathogenesis of diabetic microangiopathy were also discussed.展开更多
文摘Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR-γ ligands significantly improve myocardial functional recovery and prevent ischemia-reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR-γ ligands,we know today that the therapeutic effects of PPAR-γ ligands reach far beyond their use as insulin-sensitizers,as many of these agents exert beneficial effects in the conditions associated with ischemia-reperfusion and inflammation.
文摘In present review,the history of microangiopathy discovery and it’s modern concept were introduced and the pathophysiological changes of some vital organs in diabetes were analyzed.The roles of oxidation stress,distur-bances of microvascular functions,microvascular endothelial cell damage,PKC and PPARγ in pathogenesis of diabetic microangiopathy were also discussed.
