The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 ad...The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 adducts have an excellent efficiency in eliminating superoxide radical generated from auto oxidation of pyrogallol. At a mass concentration level of 150 μg/mL for β alanine C 60 adducts, the radical scavenging efficiency is approximately equivalent to one enzyme unit, in vitro experiments show that β alanine C 60 adducts can enhance the activity of mouse thymus cells and prolong their life time span. It reveals the potential use of these β alanine C 60 adducts as the novel potent free radical scavengers in biological systems.展开更多
Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxida...Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxidant activity of these C 60 adducts as the quencher for superoxide anion radical O -· 2 was evaluated by chemiluminescence in the system of pyrogallol-luminol. The results indicate that the three C 60 derivatives are all excellent quencher for superoxide anion radical O -· 2. The concentrations of 50% inhibition are 252, 140, 112 μmol/L respectively. This high efficiency should be attributed to many factors such as the numbers of remaining double bonds, donor effect of amino group and steric effect. However, the above results also suggest the effect of the adducted β-alanine groups is predominated in this system.展开更多
The synthesis of a novel α phosphorus containing spin trap, DEPDMPO(5 diethoxy Phosphoryl 2, 5 dimethyl 1 pyrroline \%N\% oxide) and the evaluation of its ability to spin trap the hydroxyl and the superoxide anion ra...The synthesis of a novel α phosphorus containing spin trap, DEPDMPO(5 diethoxy Phosphoryl 2, 5 dimethyl 1 pyrroline \%N\% oxide) and the evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability to trap an active superoxide anion radical generated in the photo system Ⅱ(PSII) and the stability of their spin adduct of DEPDMPO as well as three previously reported traps DMPO, DEPMPO and M 3PO were comparatively analyzed according to their chemical structures. In addition, the effects of 2 methyl and \%α\% phosphoryl substituted analogues of DMPO on the stabilities of the corresponding spin adduts were systematically展开更多
A novel well-defined water-soluble macromonomer based on 2-(dimethylamino) ethyl methacry-late(DMAEMA) was synthesized by using functional initiators such as potassium alcoholate of trimethylol-propane allyl ether via...A novel well-defined water-soluble macromonomer based on 2-(dimethylamino) ethyl methacry-late(DMAEMA) was synthesized by using functional initiators such as potassium alcoholate of trimethylol-propane allyl ether via oxyanion-initiated polymerization. GPC and 1H NMR studies confirmed that themacromonomers had narrow molecular weight distribution and each Poly(DMAEMA) chain contained apolymerizable allyl group. The macromonomers were highly surface active in aqueous media. They havepotential applications in preparation of surface-clean and functional latexes both as effective stabilizers andas co-monomers.展开更多
文摘The ability of water soluble β alanine C 60 adducts for superoxide anion radical scavenging has been studied by spectrophotometry and the modified pyrogallol auto oxidation method. It is found that β alanine C 60 adducts have an excellent efficiency in eliminating superoxide radical generated from auto oxidation of pyrogallol. At a mass concentration level of 150 μg/mL for β alanine C 60 adducts, the radical scavenging efficiency is approximately equivalent to one enzyme unit, in vitro experiments show that β alanine C 60 adducts can enhance the activity of mouse thymus cells and prolong their life time span. It reveals the potential use of these β alanine C 60 adducts as the novel potent free radical scavengers in biological systems.
文摘Three water-soluble β-alanine C 60 adducts with different addition numbers, C 60(NHCH 2CH 2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1H NMR and elemental analysis. The antioxidant activity of these C 60 adducts as the quencher for superoxide anion radical O -· 2 was evaluated by chemiluminescence in the system of pyrogallol-luminol. The results indicate that the three C 60 derivatives are all excellent quencher for superoxide anion radical O -· 2. The concentrations of 50% inhibition are 252, 140, 112 μmol/L respectively. This high efficiency should be attributed to many factors such as the numbers of remaining double bonds, donor effect of amino group and steric effect. However, the above results also suggest the effect of the adducted β-alanine groups is predominated in this system.
文摘The synthesis of a novel α phosphorus containing spin trap, DEPDMPO(5 diethoxy Phosphoryl 2, 5 dimethyl 1 pyrroline \%N\% oxide) and the evaluation of its ability to spin trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability to trap an active superoxide anion radical generated in the photo system Ⅱ(PSII) and the stability of their spin adduct of DEPDMPO as well as three previously reported traps DMPO, DEPMPO and M 3PO were comparatively analyzed according to their chemical structures. In addition, the effects of 2 methyl and \%α\% phosphoryl substituted analogues of DMPO on the stabilities of the corresponding spin adduts were systematically
文摘A novel well-defined water-soluble macromonomer based on 2-(dimethylamino) ethyl methacry-late(DMAEMA) was synthesized by using functional initiators such as potassium alcoholate of trimethylol-propane allyl ether via oxyanion-initiated polymerization. GPC and 1H NMR studies confirmed that themacromonomers had narrow molecular weight distribution and each Poly(DMAEMA) chain contained apolymerizable allyl group. The macromonomers were highly surface active in aqueous media. They havepotential applications in preparation of surface-clean and functional latexes both as effective stabilizers andas co-monomers.
