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知柏地黄丸研究进展及质量标志物预测 被引量:4
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作者 赵日杂 张剑光 +3 位作者 苏学燕 沈杰 吉部肖情 张志锋 《中华中医药学刊》 CAS 北大核心 2022年第11期196-204,共9页
知柏地黄丸为滋阴清热之名方,具有降血糖、抗氧化、抗疲劳、抗肿瘤等药理作用,临床常用于治疗更年期综合征疾病和儿童性早熟等。从草本考证、化学成分、药理作用、临床应用等对知柏地黄丸的研究进展进行综述,并根据复方中药质量标志物(q... 知柏地黄丸为滋阴清热之名方,具有降血糖、抗氧化、抗疲劳、抗肿瘤等药理作用,临床常用于治疗更年期综合征疾病和儿童性早熟等。从草本考证、化学成分、药理作用、临床应用等对知柏地黄丸的研究进展进行综述,并根据复方中药质量标志物(quality marker, Q-marker)“五原则”,从质量传递与溯源、成分特有性、成分有效性、复方配伍环境以及成分可测性等方面对知柏地黄丸Q-marker进行挖掘,初步确定芒果苷、知母皂苷BⅡ、地黄苷D、毛蕊花糖苷、盐酸小檗碱、黄柏碱、莫诺苷、马钱苷、丹皮酚、23-乙酰泽泻醇B、23-乙酰泽泻醇C为知柏地黄丸的Q-marker。研究可以为复方中药质量标志物筛选及质量控制提供研究思路。 展开更多
关键词 知柏地黄丸 质量标准物 芒果苷 知母皂苷BⅡ 地黄苷D 毛蕊花糖苷 盐酸小檗碱 黄柏碱 莫诺苷 马钱苷 丹皮酚 23-乙酰泽泻醇B 23-乙酰泽泻醇C
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Spatial distribution and environmental characterization of sediment-associated metals from middle-downstream of Xiangjiang River,southern China 被引量:9
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作者 郭朝晖 宋杰 +3 位作者 肖细元 明辉 苗旭锋 王凤永 《Journal of Central South University》 SCIE EI CAS 2010年第1期68-78,共11页
The contamination and environmental risk assessment of the toxic elements in sediments from the middle-downstream (Zhuzhou-Changsha section) of the Xiangjiang River in Hunan Province of China were studied. The results... The contamination and environmental risk assessment of the toxic elements in sediments from the middle-downstream (Zhuzhou-Changsha section) of the Xiangjiang River in Hunan Province of China were studied. The results show that As, Cd, Pb and Zn are major contaminants in sediments, and average concentrations of these elements significantly exceed both the Control Standards for Pollutants in Sludge of China (GB4284-84) for agricultural use in acidic soils and the effect range median (ERM) values. The average concentrations of As, Cd and Pb in the river water slightly exceed the limit of Surface Water Environment Quality Standard (GB3838-2002). The concentrations of As and Cr in depth profiles extensively change, but slight changes are observed in Pb and Zn. Cd and Zn in most sediment samples can easily enter the food-chain and bring possible ecotoxicological risk to organisms living in sediments according to the risk assessment code. 展开更多
关键词 SEDIMENT toxic elements spatial distribution environmental risk Xiangjiang River
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Evaluation of protective quality of prestressed concrete containment buildings of nuclear power plants
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作者 郑砚国 李惠强 《Journal of Central South University》 SCIE EI CAS 2011年第1期238-243,共6页
The permeability and sorptivity properties of the two prestressed concrete containment buildings (PCCBs) of a nuclear power plant in South China, which had been under operation for 5 years, were measured by using th... The permeability and sorptivity properties of the two prestressed concrete containment buildings (PCCBs) of a nuclear power plant in South China, which had been under operation for 5 years, were measured by using the autoclam permeability system. The air permeability, sorptivity and water permeability indexes of No.1 PCCB are smaller than or equal to 0.11 ln(102 Pa)/min, 0.98×10 ^7 m3/minl/2 and 1.93×10 ^7 m3/min1/2, respectively, and the air permeability, sorptivity and water permeability indexes of No.2 PCCB are smaller than or equal to 0.17 In(102 Pa)/min, 1.6×10 ^7 m3/min1/2 and 4.43 ×10 ^7 m3/min1/2, respectively. Based on the criteria for evaluating the protective quality of concrete structures in terms of their permeability and sorptivity properties, proposed by the research organization of the autoclam permeability system, the protective quality of No. 1 PCCB is still in very good grade and that of No.2 PCCB is not in very good grade but in good grade, and the in-service inspection of the protective quality of No.2 PCCB should be strengthened in the future. 展开更多
关键词 nuclear power plant prestressed concrete containment building permeability properties sorptivity properties
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