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唐氏综合征小鼠模型的遗传背景和应用 被引量:2
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作者 孟晓伟 汪洁 +1 位作者 马晴雯 卢大儒 《遗传》 CAS CSCD 北大核心 2018年第3期207-217,共11页
唐氏综合征(Down syndrome,DS)是最常见的常染色体异常疾病,由人类21号染色体(human chromosome21,Hsa21)的重复引起。由于Hsa21的直系同源基因分散于小鼠16、17和10号染色体上,所以用小鼠模拟人类唐氏综合征并不容易。早期的Ts65Dn小... 唐氏综合征(Down syndrome,DS)是最常见的常染色体异常疾病,由人类21号染色体(human chromosome21,Hsa21)的重复引起。由于Hsa21的直系同源基因分散于小鼠16、17和10号染色体上,所以用小鼠模拟人类唐氏综合征并不容易。早期的Ts65Dn小鼠虽然具有DS表型特征,但其重复片段由电离辐射产生,未包含所有Hsa21直系同源基因。2004年,Cre/Lox P重组酶系统介导的染色体编辑技术在Ts1Rhr小鼠中的成功应用,解决了特定片段重复化的难题,使DS小鼠模型在基因重复和表型模拟方面实现了精准化。本文从同源基因重复和DS表型模拟两方面简要介绍了不同时期DS小鼠模型的优势和局限,为科研人员在DS研究中对不同小鼠模型的选用提供了参考。 展开更多
关键词 唐氏综合征 小鼠模型 基因重复 表型模拟
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Method of closed loop springback compensation for incremental sheet forming process 被引量:1
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作者 韩飞 莫健华 +1 位作者 龚攀 李敏 《Journal of Central South University》 SCIE EI CAS 2011年第5期1509-1517,共9页
The closed loop control model was built up for compensating the springback and enhancing the work piece precision.A coupled closed loop algorithm and a finite element method were developed to simulate and correct the ... The closed loop control model was built up for compensating the springback and enhancing the work piece precision.A coupled closed loop algorithm and a finite element method were developed to simulate and correct the springback of incremental sheet forming.A three-dimensional finite element model was established for simulation of springback in incremental sheet forming process.The closed loop algorithm of trajectory profile for the incremental sheet forming based on the wavelet transform combined with fast Fourier transform was constructed.The profile of processing tool path of shallow dishing with spherical surface was designed on the basis of the profile correction algorithm.The result shows that the algorithm can predict an ideal profile of processing track,and the springback error of incremental sheet forming is eliminated effectively.It has good convergence efficiency,and can improve the workpiece dimensional accuracy greatly. 展开更多
关键词 incremental sheet forming spingback numerical simulation closed loop control
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