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旅游企业聚集的行为学机制模型研究 被引量:1
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作者 张立生 万年庆 +2 位作者 王海燕 万钧 王黎明 《热带地理》 北大核心 2010年第4期440-444,共5页
利用规范分析法建立了针对旅游企业聚集现象的行为学分析模型,并论证了时间要素在旅游企业聚集中的作用。文中首先简单总结了前人有关旅游企业聚集的研究成果,然后在系列假设条件的基础上,将时间因素作为内生变量,分析了旅游者节约... 利用规范分析法建立了针对旅游企业聚集现象的行为学分析模型,并论证了时间要素在旅游企业聚集中的作用。文中首先简单总结了前人有关旅游企业聚集的研究成果,然后在系列假设条件的基础上,将时间因素作为内生变量,分析了旅游者节约时间因素的行为对旅游企业聚集作用的机理。分析表明,时间因素是旅游企业聚集的重要动态因素之一。对有关基于“旅游人”和“经济人”假设下的两种理论的分析表明,两种理论存在互相补充的关系。 展开更多
关键词 旅游企业聚集 规范分析法 行为分析模型 时间
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灵芝孢子油干预治疗6-羟多巴帕金森病大鼠模型的实验研究 被引量:12
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作者 朱蔚文 刘焯霖 +3 位作者 徐浩文 谢安木 叶钦勇 陈玲 《中山大学学报(医学科学版)》 CAS CSCD 北大核心 2005年第4期417-420,共4页
【目的】研究灵芝孢子油对6-羟多巴(6-OHDA)帕金森病(PD)大鼠模型行为学及病理改变的影响,探讨该药对黑质多巴胺能神经元的保护作用。【方法】100只SD大鼠随机分为正常对照组20只、6-OHDA组40只、灵芝孢子油+6-OHDA组40只。通过脑部立... 【目的】研究灵芝孢子油对6-羟多巴(6-OHDA)帕金森病(PD)大鼠模型行为学及病理改变的影响,探讨该药对黑质多巴胺能神经元的保护作用。【方法】100只SD大鼠随机分为正常对照组20只、6-OHDA组40只、灵芝孢子油+6-OHDA组40只。通过脑部立体定向法将6-OHDA注射到SD大鼠一侧黑质致密部建立6-OHDA大鼠PD模型,灵芝孢子油+6-OHDA组在造模前3d开始给灵芝孢子油每天500mg/kg,连续10d。6-OHDA组喂食生理盐水做对照。造模后每周给予阿朴吗啡观察大鼠旋转行为的变化,4周后用高效液相色谱法检测大鼠纹状体多巴胺及其代谢物含量,免疫组织化学法检测黑质致密部酪氨酸羟化酶(TH)阳性细胞数量,westernblot法对TH蛋白进行半定量测定。【结果】①灵芝孢子油+6-OHDA组出现旋转行为的大鼠比例为10%,6-OHDA组为45%,两组比较有显著性差异。②纹状体多巴胺及其代谢物含量在两组间存在差异,多巴胺手术侧含量/手术对侧含量在灵芝孢子油+6-OHDA组为(60.12±7.5)%,在6-OHDA组为(38.58±7.26)%。③在黑质致密带区灵芝孢子油+6-OHDA组的TH免疫阳性细胞及TH蛋白表达量均较6-OHDA组显著增多。【结论】灵芝孢子油能明显改善6-OHDA大鼠模型行为学,增加纹状体多巴胺及其代谢物含量并提高黑质多巴胺能神经元的残存率,提示灵芝孢子油可能具有减缓PD病变进程的神经保护作用。 展开更多
关键词 灵芝孢子油 6-羟多巴 帕金森病 实验研究 大鼠模型 干预治疗 黑质多巴胺能神经元 6-OHDA 纹状体多巴胺 免疫组织化 高效液相色谱法 western 模型行为 黑质致密部 酪氨酸羟化酶 免疫阳性细胞 神经保护作用 SD大鼠
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斑马鱼模式动物在神经功能环路研究中的应用 被引量:1
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作者 陈思杰 彭刚 《心理科学进展》 CSSCI CSCD 北大核心 2013年第6期1014-1019,共6页
斑马鱼是发育、遗传以及药物发现研究中常用的模式动物。作为重要的脊椎动物模式系统之一,斑马鱼与人类基因有高度同源性,中枢神经系统也与哺乳动物相似。近来,斑马鱼在神经科学研究以及生理心理学相关问题的研究中的应用日益广泛。研... 斑马鱼是发育、遗传以及药物发现研究中常用的模式动物。作为重要的脊椎动物模式系统之一,斑马鱼与人类基因有高度同源性,中枢神经系统也与哺乳动物相似。近来,斑马鱼在神经科学研究以及生理心理学相关问题的研究中的应用日益广泛。研究者们对斑马鱼幼鱼及成鱼的行为表现及行为发育开展了多方面的研究。基于斑马鱼模式动物的特点及优势,遗传突变和药物筛选在对动物行为表现的分子机制的研究中起到重要的推动作用。 展开更多
关键词 斑马鱼 行为学模型 行为发育 遗传突变 药物筛选
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Analytical approach and field monitoring for mechanical behaviors of pipe roof reinforcement 被引量:4
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作者 王海涛 贾金青 康海贵 《Journal of Central South University》 SCIE EI CAS 2009年第5期827-834,共8页
Considering the delay effect of initial lining and revising the Winkler elastic foundation model,an analytical approach based on Pasternak elastic foundation beam theory for pipe roof reinforcement was put forward. Wi... Considering the delay effect of initial lining and revising the Winkler elastic foundation model,an analytical approach based on Pasternak elastic foundation beam theory for pipe roof reinforcement was put forward. With the example of a certain tunnel excavation,the comparison of the values of longitudinal strain of reinforcing pipe between field monitoring and analytical approach was made. The results indicate that Pasternak model,which considers a more realistic hypothesis in the elastic soil than Winkler model,gives more accurate calculation and agrees better with the result of field monitoring. The difference of calculation results between these two models is about 7%,and Pasternak model is proved to be a better way to study the reinforcement mechanism and improve design practice. The calculation results also reveal that the reinforcing pipes act as levers,which increases longitudinal load transfer to an unexcavated area,and consequently decreases deformation and increases face stability. 展开更多
关键词 tunnel heading pipe roof reinforcement Pasternak elastic foundation beam field monitoring
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Individual departure time decision considering departure scheduling utility
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作者 张文义 关伟 +1 位作者 孙会君 毛保华 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第2期787-792,共6页
The scheduling utility plays a fundamental role in addressing the commuting travel behaviours. A new scheduling utility,termed as DMRD-SU, was suggested based on some recent research findings in behavioural economics.... The scheduling utility plays a fundamental role in addressing the commuting travel behaviours. A new scheduling utility,termed as DMRD-SU, was suggested based on some recent research findings in behavioural economics. DMRD-SU admitted the existence of positive arrival-caused utility. In addition, besides the travel-time-caused utility and arrival-caused utility, DMRD-SU firstly took the departure utility into account. The necessity of the departure utility in trip scheduling was analyzed comprehensively,and the corresponding individual trip scheduling model was presented. Based on a simple network, an analytical example was executed to characterize DMRD-SU. It can be found from the analytical example that: 1) DMRD-SU can predict the accumulation departure behaviors at NDT, which explains the formation of daily serious short-peak-hours in reality, while MRD-SU cannot; 2)Compared with MRD-SU, DMRD-SU predicts that people tend to depart later and its gross utility also decreases faster. Therefore,the departure utility should be considered to describe the traveler's scheduling behaviors better. 展开更多
关键词 trip scheduling scheduling utility reference-dependence departure utility
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Elastoplastic modeling of mechanical behavior of weak sandstone at different time scales
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作者 WANG Jing-yin 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第3期699-707,共9页
A unified constitutive model is proposed to describe the mechanical behavior of weak sandstone at different time scales.The instantaneous behavior of this material is characterized by the Drucker-Prager elastoplastic ... A unified constitutive model is proposed to describe the mechanical behavior of weak sandstone at different time scales.The instantaneous behavior of this material is characterized by the Drucker-Prager elastoplastic model,while the time-dependent deformation is described in terms of the microstructure evolution.This evolution is numerically simulated by progressive degradation of the elastic modulus and failure strength of the material.The proposed model is used to simulate the instantaneous triaxial compression and the multi-loading creep tests.Generally,good concordance is obtained between numerical simulations and experimental data.The proposed model is capable of describing the main features of these rocks,particularly irreversible deformations,pressure dependency,volumetric transition between compaction and dilatancy,and creep behavior. 展开更多
关键词 weak sandstone elastoplasticity creep behavior constitutive model MICROSTRUCTURE
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Analytical and numerical solutions for shear mechanical behaviors of structural plane
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作者 何忠明 熊喆怡 +1 位作者 胡庆国 杨明 《Journal of Central South University》 SCIE EI CAS 2014年第7期2944-2949,共6页
The original descriptive model of shear stress and shear displacement only reflects the stress deformation characteristics of plastic structural plane.The index model was revised and piecewise index model was built to... The original descriptive model of shear stress and shear displacement only reflects the stress deformation characteristics of plastic structural plane.The index model was revised and piecewise index model was built to describe the stress deformation characteristics of plastic structural plane and brittle structural plane.The relation of stress and strain to the failure mode of structural plane considering the effect of its shape was investigated,and a model which could reflect the relation between undulate angle and shear strength was built.The result indicates that structural plane presents nonlinear characteristics,specifically,the value of undulate angle,as well as corresponding shear strength,becomes larger as the normal stress decreases. 展开更多
关键词 structural plane shear mechanical behavior model failure mode nonlinear characteristics numerical analysis
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