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早发型2型糖尿病患者子女颈动脉全息血管硬度及影响因素分析 被引量:1
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作者 陈纪昀 郭艳艳 +3 位作者 袁建军 张喜君 吴铭 朱好辉 《中国医学影像学杂志》 CSCD 北大核心 2024年第9期897-902,共6页
目的评估早发型2型糖尿病患者子女颈动脉弹性功能,并分析影响其弹性的因素。资料与方法前瞻性分析2020年10月—2021年8月河南省人民医院2型糖尿病患者子女63例,根据其父母糖尿病发病年龄(<40岁为早发型,≥40岁为晚发型)分为父母早发... 目的评估早发型2型糖尿病患者子女颈动脉弹性功能,并分析影响其弹性的因素。资料与方法前瞻性分析2020年10月—2021年8月河南省人民医院2型糖尿病患者子女63例,根据其父母糖尿病发病年龄(<40岁为早发型,≥40岁为晚发型)分为父母早发糖尿病子女组(早发组,32例)和父母晚发糖尿病子女组(晚发组,31例)。同期选择32例年龄、性别及体重指数相匹配的健康志愿者作为对照组。应用全息血管内-中膜厚度测量和全息血管硬度分析技术测量受试者颈总动脉内-中膜厚度、血管壁位移、血管收缩期管径、硬度指数和脉搏波传导速度,比较上述参数的组间差异。结果早发组颈动脉内-中膜厚度、脉搏波传导速度、硬度指数高于晚发组及对照组(t=0.054~1.228,P均<0.05),血管壁位移低于晚发组及对照组(t=0.048、0.109,P<0.05)。结论2型糖尿病患者子女颈动脉僵硬度明显高于正常对照组,且早发组的颈动脉弹性下降较晚发组更明显。 展开更多
关键词 糖尿病 2型 超声检查 颈动脉弹性 颈动脉内膜中层厚度 全息血管硬度分析技术 早发型 子女
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全息血管硬度分析技术评价不同病程1型糖尿病患儿颈动脉弹性功能
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作者 纪淑姣 徐雪艳 +3 位作者 朱好辉 牛瑜琳 张喜君 陈永兴 《中国医学影像学杂志》 CSCD 北大核心 2024年第12期1231-1236,共6页
目的应用全息血管硬度分析技术评价1型糖尿病(T1DM)患儿颈动脉弹性功能与糖尿病病程和血糖控制情况的相关性。资料与方法前瞻性收集2019年9月—2021年11月河南省胸科医院儿科、河南省人民医院儿科、河南省儿童医院内分泌遗传代谢科已确... 目的应用全息血管硬度分析技术评价1型糖尿病(T1DM)患儿颈动脉弹性功能与糖尿病病程和血糖控制情况的相关性。资料与方法前瞻性收集2019年9月—2021年11月河南省胸科医院儿科、河南省人民医院儿科、河南省儿童医院内分泌遗传代谢科已确诊的T1DM患儿75例,按照T1DM患儿病程分为长病程组(病程≥5年)30例,短病程组(病程<5年)45例;同时收集年龄、性别相匹配的正常对照组30例。用全息血管硬度分析技术测量颈总动脉血管收缩期直径、血管位移、脉搏波传导速度(PWV)和硬度系数、颈总动脉内-中膜厚度;同期收集血糖及血脂指标,比较3组间各参数的差异。结果长病程组、短病程组空腹血糖、糖化血红蛋白和内-中膜厚度均高于对照组,差异有统计学意义(P均<0.05);3组PWV、硬度系数、血管位移差异有统计学意义(F=22.854、16.811,H=33.214,P均<0.001)。病程与PWV、硬度系数具有相关性(r=0.621、0.517,P<0.001);糖化血红蛋白与PWV具有相关性(r=0.562,P<0.001)。结论T1DM患儿早期即可出现颈动脉弹性减退,高血糖持续时间越长,动脉弹性受损程度越重。全息血管硬度分析技术是一种简单有效且无创的动脉弹性评估方法,为临床提供诊疗依据。 展开更多
关键词 全息血管硬度分析技术 颈动脉弹性 糖尿病 1型 儿童
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基于示波法的血管硬度无创检测系统
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作者 赵学玲 吴萍 +3 位作者 徐可欣 陈小红 刘瑾 杜振辉 《电子技术应用》 北大核心 2008年第6期129-131,134,共4页
在示波法测量血压的原理基础上,设计和开发了血压与血管硬度的无创检测系统。该系统以MOTOROLA单片机MC68HC908JL8为控制核心,在血压测量过程中,从采集到的血压波形信号中高精度地提取血管硬度的有效信息,并通过大量的临床实验数据的分... 在示波法测量血压的原理基础上,设计和开发了血压与血管硬度的无创检测系统。该系统以MOTOROLA单片机MC68HC908JL8为控制核心,在血压测量过程中,从采集到的血压波形信号中高精度地提取血管硬度的有效信息,并通过大量的临床实验数据的分析,建立相应的血管硬度的模型,实现了在无创血压测量的同时,检测出血管硬度指数、心率等多种心血管参数。临床实验表明,该检测系统能够较好地反映人体的血管健康状况。 展开更多
关键词 血压 血管硬度 示波法 MC68HC908 斜波比较
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银杏蜜环口服溶液联合丹参酮ⅡA磺酸钠治疗不稳定型心绞痛46例 被引量:4
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作者 鲁爱粉 张敏 《现代中医药》 CAS 2019年第6期58-62,共5页
目的探究银杏蜜环口服溶液联合丹参酮ⅡA磺酸钠治疗不稳定型心绞痛(Unstable angina pectoris,UAP)患者的临床效果。方法选取2016年6月~2018年10月濮阳市油田总医院UAP患者92例,以随机数字表法分为治疗组(n=46)、对照组(n=46)。常规治... 目的探究银杏蜜环口服溶液联合丹参酮ⅡA磺酸钠治疗不稳定型心绞痛(Unstable angina pectoris,UAP)患者的临床效果。方法选取2016年6月~2018年10月濮阳市油田总医院UAP患者92例,以随机数字表法分为治疗组(n=46)、对照组(n=46)。常规治疗基础上,对照组予以丹参酮ⅡA磺酸钠治疗,治疗组予以银杏蜜环口服溶液联合丹参酮ⅡA磺酸钠,均治疗2周。对比两组治疗2周后临床、心电图疗效与治疗前、治疗2周后臂踝脉搏波速度、血浆血液流变学指标(纤维蛋白原、血浆黏度、红细胞压积)水平。结果治疗组治疗2周后临床、心电图疗效均较对照组良好(P<0.05);两组治疗前臂踝脉搏波速度相比,差异无统计学意义(P>0.05);两组治疗2周后臂踝脉搏波速度均较治疗前降低,且治疗组低于对照组(P<0.05);两组治疗2周后血浆纤维蛋白原、血浆黏度、红细胞压积水平均较治疗前降低,且治疗组低于对照组(P<0.05)。结论对不稳定型心绞痛患者应用银杏蜜环口服溶液联合丹参酮ⅡA磺酸钠治疗可降低血管硬度,改善血流流变学情况,疗效显著。 展开更多
关键词 银杏蜜环口服溶液 丹参酮ⅡA磺酸钠 不稳定型心绞痛 血液流变学 血管硬度
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Association between serum homocysteine and arterial stiffness in elderly: a community-based study 被引量:28
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作者 Song ZHANG Yong-Yi BAI +3 位作者 Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第1期32-38,共7页
Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial... Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arte- rial stiffness (carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV) in 780 participants (46.3% men, mean age 71.9 years (ranging 65-96 years old)) from two communities of Beijing, China. Arterial stiffness were measured within two days of the time of bio- marker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV (standardized 13 = 0.13, P 〈 0.001), even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for ca-rotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness. 展开更多
关键词 The elderly HOMOCYSTEINE Arterial stiffness Pulse wave velocity
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Association between serum homocysteine and arterial stiffness:role of anti-hypertensive drugs 被引量:8
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作者 Ercan Varol 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第2期175-175,共1页
To the Editor I read the article of Zhang, et al. with great interest. They investigated the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. The carotid-femoral pulse wa... To the Editor I read the article of Zhang, et al. with great interest. They investigated the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. The carotid-femoral pulse wave velocity (PWV) was significantly higher in the high homocyteine group than in the normal one, however, there was no differences in carotid-radial PWV between the high homocyteine group and the normal one. Homocysteine levels were strongly associated with the carotidfemoral PWV even after adjustment for classical risk factors of cardiovascular disease. I congratulate the authors for this important study. However, I want to make minor criticism for this study from the methodological aspect. 展开更多
关键词 HOMOCYSTEINE Arterial stiffness HYPERTENSION Antihypertensive drugs
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CAROTID INTIMA- MEDIA THICKNESS AND THE ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS IN THE ELDERLY 被引量:1
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作者 叶平 王节 +1 位作者 尚延忠 朱平 《Chinese Medical Sciences Journal》 CAS CSCD 2001年第1期15-18,共4页
To investigate the association of carotid arterial intima- media thickness (IMT) with principal cardiovascular risk factors in the elderly. Methods. Carotid arterial IMT was measured by high resolution B mode ultrasou... To investigate the association of carotid arterial intima- media thickness (IMT) with principal cardiovascular risk factors in the elderly. Methods. Carotid arterial IMT was measured by high resolution B mode ultrasound in 94 elderly subjects (old- aged group), and compared with subjects aged Results. In comparison with the middle- aged group, the prevalence of coronary heart disease, cerebral vascular disease, hypertension and diabetes mellitus was significantly higher, and serum cholesterol and systolic blood pressure were also significantly higher in old- aged group. Although there was no obvious difference in IMT between the two groups, carotid plaque and carotid wall thickening were more frequently found in old- aged group. Age, systolic blood pressure and serum cholesterol were shown as the independent determinants for carotid IMT in the total participants, whereas no such independent relation was found in old- aged group. Conclusion. Age is the major risk factor for carotid atherosclerosis in the elderly. In other words, the occurrence of carotid atherosclerosis is the result of advancing age combined with the effect of multiple cardiovascular risk factors. 展开更多
关键词 the elderly carotid artery ATHEROSCLEROSIS risk factors
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