Autophagy is a vacuolar process of cytoplasmic degradation by lysosome which ubiquitously occurring in all eukaryotic cells. The researches of autophagy have made great progress with the development of the yeast model...Autophagy is a vacuolar process of cytoplasmic degradation by lysosome which ubiquitously occurring in all eukaryotic cells. The researches of autophagy have made great progress with the development of the yeast model and genetic technology. This review will summarize the determination of autophagy,its relationship with apoptosis and its role in the tumor treatment in order to give a comprehensive understanding of the function of autophagy.展开更多
Autophagy is a lysosome-dependent degradative pathway which is characterized by cytoplasmic vacuolization. However,it is not just a simple degradative pathway. Research shows that autophagy is related to many diseases...Autophagy is a lysosome-dependent degradative pathway which is characterized by cytoplasmic vacuolization. However,it is not just a simple degradative pathway. Research shows that autophagy is related to many diseases,such as neurodegenerative disease,malignant tumor,ageing,pathogenic microorganism infection,myocardial ischemia/reperfusion injury and so on. Autophagy exactly exists in myocardial ischemia/reperfusion injury,and it becomes a new research hotspot. This review will focus on the occurrence and development of autophagy and its role,signal transduction and research status in myocardial ischemia/reperfusion injury.展开更多
文摘Autophagy is a vacuolar process of cytoplasmic degradation by lysosome which ubiquitously occurring in all eukaryotic cells. The researches of autophagy have made great progress with the development of the yeast model and genetic technology. This review will summarize the determination of autophagy,its relationship with apoptosis and its role in the tumor treatment in order to give a comprehensive understanding of the function of autophagy.
文摘Autophagy is a lysosome-dependent degradative pathway which is characterized by cytoplasmic vacuolization. However,it is not just a simple degradative pathway. Research shows that autophagy is related to many diseases,such as neurodegenerative disease,malignant tumor,ageing,pathogenic microorganism infection,myocardial ischemia/reperfusion injury and so on. Autophagy exactly exists in myocardial ischemia/reperfusion injury,and it becomes a new research hotspot. This review will focus on the occurrence and development of autophagy and its role,signal transduction and research status in myocardial ischemia/reperfusion injury.
