针对脉搏波波速法无创血压测量中血压计算模型建模困难和模型计算精度较低的问题,结合TPTT、ln(TPTT)及(1/TPTT)2等模量建立多模量血压计算模型。首先,利用99名随机测试者的实验数据确定多模量模型参数,并基于实验数据计算各模型性能评...针对脉搏波波速法无创血压测量中血压计算模型建模困难和模型计算精度较低的问题,结合TPTT、ln(TPTT)及(1/TPTT)2等模量建立多模量血压计算模型。首先,利用99名随机测试者的实验数据确定多模量模型参数,并基于实验数据计算各模型性能评价指标,其中多模量血压计算模型拟合相关系数最大,为0.891,误差方差最小,仅为6.1,实验表明,多模量血压计算模型具有更好的拟合效果和更低的计算误差。然后,利用医用水银血压计和自主设计的多模量血压测量系统两种方法采集另外36名随机测试者的收缩压和舒张压数据,并计算两种方法采集数据间的相关参数,其中收缩压差值的绝对值d<6 mm Hg,差值均值E_d=0.55 mm Hg,差值的标准差δ_d=2.98 mm Hg;舒张压差值的绝对值d<6 mm Hg,差值均值E_d=0.57 mm Hg,差值的标准差δ_d=3.42 mm Hg,完全符合美国医疗仪器促进协会SP10-199中对电子血压计测量差值<8 mm Hg的要求。最后,采用Bland-Altman差值法,对两种方法测量数据一致性进行检验,发现舒张压与收缩压的95%一致性界限分别为(-5.3,6.4)和(7.2,-6.2),完全在临床血压测量可接受范围之内,较好地证明多模量血压计算模型用于无创血压测量的有效性。研究结果表明,多模量血压计算模型可以应用于脉搏波波速法无创血压测量。展开更多
Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid a...Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly展开更多
文摘针对脉搏波波速法无创血压测量中血压计算模型建模困难和模型计算精度较低的问题,结合TPTT、ln(TPTT)及(1/TPTT)2等模量建立多模量血压计算模型。首先,利用99名随机测试者的实验数据确定多模量模型参数,并基于实验数据计算各模型性能评价指标,其中多模量血压计算模型拟合相关系数最大,为0.891,误差方差最小,仅为6.1,实验表明,多模量血压计算模型具有更好的拟合效果和更低的计算误差。然后,利用医用水银血压计和自主设计的多模量血压测量系统两种方法采集另外36名随机测试者的收缩压和舒张压数据,并计算两种方法采集数据间的相关参数,其中收缩压差值的绝对值d<6 mm Hg,差值均值E_d=0.55 mm Hg,差值的标准差δ_d=2.98 mm Hg;舒张压差值的绝对值d<6 mm Hg,差值均值E_d=0.57 mm Hg,差值的标准差δ_d=3.42 mm Hg,完全符合美国医疗仪器促进协会SP10-199中对电子血压计测量差值<8 mm Hg的要求。最后,采用Bland-Altman差值法,对两种方法测量数据一致性进行检验,发现舒张压与收缩压的95%一致性界限分别为(-5.3,6.4)和(7.2,-6.2),完全在临床血压测量可接受范围之内,较好地证明多模量血压计算模型用于无创血压测量的有效性。研究结果表明,多模量血压计算模型可以应用于脉搏波波速法无创血压测量。
文摘Objective Brachial-ankle pulse wave velocity （baPWV） is widely used as a simple noninvasive measure of arterial softness. The aim of this study was to evaluate the usefulness of baPWV as a predictor of the carotid artery atherosclerosis in the elderly. Methods A total of 721 elderly participants （mean ~ SD age, 70.3 -4- 5.6years） were enrolled in the current study. All participant underwent both baPWV measurement and B-mode ultrasound for the intima-media thickness. Carotid atherosclerosis （CAS） was defined as the present of carotid plaque or and/or intima media thickness for at least 1.1 mm. Results A multivariate logistic regression analysis reveals that age, sex, brachial-ankle pulse wave velocity, smoking and LDL-C level showed a significant correlation with the presence of CAS. The odds ratios of CAS associated with a 500cm/s increase of brachial-ankle pulse wave velocity were 2.378 [95% confidence interval, 1.36 to 4.00, P〈0.05], 3.733 [95% confidence interval, 1.729 to 8.058, P〈0.01], 4.438 [95% confidence interval, 1.659 to 11.803, P〈0.01]. The baPWV significantly correlated with IMT by bivariate correlation analysis （r=-0.39; p=0.001）. After adjusting for factors influencing, baPWV all the same correlated with IMT （r=-0.35; p=0.001）.Conclusion These results indicate that brachial-ankle PWV is an independent predictor of CAS in the elderly.It also means that the direct measurement of arterial stiffness by this simple method may be of great help for the evaluation of carotid artherosclerosis, at least in the elderly
