The nature of renal tubular cell injury in ischemic acute renal failure includes not only cell death (necrosis or apoptosis) but also sublethal injury causing cell dysfunction. The role of intracellu- lar calcium, cal...The nature of renal tubular cell injury in ischemic acute renal failure includes not only cell death (necrosis or apoptosis) but also sublethal injury causing cell dysfunction. The role of intracellu- lar calcium, calcium - dependent enzymes calpain, nitric oxide, phospholipase A2, loss of tubule cell polarity and tubular obstruction in the pathophysiology of the renal tubular cell injury during hypoxia/ischemia is described. The effects of vascular factors, infiltrating activited leukocytes, apoptosis and growth factors on renal tubular cell injury are discussed. Potential mechanisms that tubular injury leads to a profound fall in glomerular filtration rate are proposed.展开更多
本文在以往研究证实天然虫草对氨基糖甙肾毒性损害具有良好防治作用的基础上,以人工培植虫草替代天然虫草,观察它对体外培养肾小管上皮细胞增殖,对庆大霉素所致大鼠急性肾毒性损害及庆大霉素血药浓度的影响。结果表明,人工虫草可减轻庆...本文在以往研究证实天然虫草对氨基糖甙肾毒性损害具有良好防治作用的基础上,以人工培植虫草替代天然虫草,观察它对体外培养肾小管上皮细胞增殖,对庆大霉素所致大鼠急性肾毒性损害及庆大霉素血药浓度的影响。结果表明,人工虫草可减轻庆大霉索对肾的损害,使大鼠尿 NAG 酶排泄量减少,保钠功能相对保存,血尿素氮、肌酐上升幅度小,其菊粉清除率高于单用庆大霉素对照组.人工虫草与庆大霉素联合应用既不影响庆大霉素血药浓度,也不减少肾皮质的庆大霉素积聚量,提示其保护肾脏的机理可能不是通过抑制庆大霉素转运和拮抗庆大霉素的药理作用。而主要是通过促进对损害、坏死的肾小管细胞再生和修复。展开更多
文摘The nature of renal tubular cell injury in ischemic acute renal failure includes not only cell death (necrosis or apoptosis) but also sublethal injury causing cell dysfunction. The role of intracellu- lar calcium, calcium - dependent enzymes calpain, nitric oxide, phospholipase A2, loss of tubule cell polarity and tubular obstruction in the pathophysiology of the renal tubular cell injury during hypoxia/ischemia is described. The effects of vascular factors, infiltrating activited leukocytes, apoptosis and growth factors on renal tubular cell injury are discussed. Potential mechanisms that tubular injury leads to a profound fall in glomerular filtration rate are proposed.
文摘本文在以往研究证实天然虫草对氨基糖甙肾毒性损害具有良好防治作用的基础上,以人工培植虫草替代天然虫草,观察它对体外培养肾小管上皮细胞增殖,对庆大霉素所致大鼠急性肾毒性损害及庆大霉素血药浓度的影响。结果表明,人工虫草可减轻庆大霉索对肾的损害,使大鼠尿 NAG 酶排泄量减少,保钠功能相对保存,血尿素氮、肌酐上升幅度小,其菊粉清除率高于单用庆大霉素对照组.人工虫草与庆大霉素联合应用既不影响庆大霉素血药浓度,也不减少肾皮质的庆大霉素积聚量,提示其保护肾脏的机理可能不是通过抑制庆大霉素转运和拮抗庆大霉素的药理作用。而主要是通过促进对损害、坏死的肾小管细胞再生和修复。
