The solid condensation of isopropylidene malonate with aromatic aldehydes were carried out by grinding at room temperature or heating at 110～120 ℃ to give 5 arylidene 2,2 dimethyl 1,3 dioxane 4,6 dione . Both condit...The solid condensation of isopropylidene malonate with aromatic aldehydes were carried out by grinding at room temperature or heating at 110～120 ℃ to give 5 arylidene 2,2 dimethyl 1,3 dioxane 4,6 dione . Both conditions afford the condensation high reaction activity. The yield of the product under grinding for 20 min followed by standing for 48 h at room temperature is 56%～80% and that by heating at 110～120 ℃ for 12 min is 55%～74%, respectively.展开更多
The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the rea...The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger arids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate.展开更多
文摘The solid condensation of isopropylidene malonate with aromatic aldehydes were carried out by grinding at room temperature or heating at 110～120 ℃ to give 5 arylidene 2,2 dimethyl 1,3 dioxane 4,6 dione . Both conditions afford the condensation high reaction activity. The yield of the product under grinding for 20 min followed by standing for 48 h at room temperature is 56%～80% and that by heating at 110～120 ℃ for 12 min is 55%～74%, respectively.
基金The project was supported by the National Natural Science Foundation of China(21163016,21174114)Gansu Provincial Natural Science Foundation,China(1010RJZA024)Scientific Research Fund of Northwest Normal University,China(NWNU-KJCXGC-03-63)~~
文摘The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger arids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate.
