Caveolae are vesicular invaginations in the plasma membrane,caveolin-1 is the marker protein of caveolae.Recently,much attention has been paid to the functions of caveolae/caveolin-1.Studies show that the disorders of...Caveolae are vesicular invaginations in the plasma membrane,caveolin-1 is the marker protein of caveolae.Recently,much attention has been paid to the functions of caveolae/caveolin-1.Studies show that the disorders of cellular cholesterol homeostasis participate in the development of atherosclerosis.Meanwhile,caveolar/caveolin-1 play a critical role in the regulation of cellular cholesterol transport and homeostasis,cell proliferation and migration,signal transduction and tumor suppression and so on.In this review,we provide an in-depth summary regarding the research development of caveolae/caveolin-1 and cellular cholesterol transport.展开更多
文摘Caveolae are vesicular invaginations in the plasma membrane,caveolin-1 is the marker protein of caveolae.Recently,much attention has been paid to the functions of caveolae/caveolin-1.Studies show that the disorders of cellular cholesterol homeostasis participate in the development of atherosclerosis.Meanwhile,caveolar/caveolin-1 play a critical role in the regulation of cellular cholesterol transport and homeostasis,cell proliferation and migration,signal transduction and tumor suppression and so on.In this review,we provide an in-depth summary regarding the research development of caveolae/caveolin-1 and cellular cholesterol transport.
