Fatty liver fibrosis, a severe type of Nonalcoholic fatty liver disease （NAFLD）, can be reversed by effec- tive medical intervention. Endoplasmic reticulum stress promotes liver fat accumulation and induction of in...Fatty liver fibrosis, a severe type of Nonalcoholic fatty liver disease （NAFLD）, can be reversed by effec- tive medical intervention. Endoplasmic reticulum stress promotes liver fat accumulation and induction of inflammatory cytokines, which plays an important role in the process of liver fibrosis. Our previous study have shown that, SPJ （saponins of Panax Japonicus） has significant antioxidant and anti-inflammatory activity. Therefore, the protective effects and mechanisms of SPJ against fatty liver fibrosis in mice were investigated. In this study, fatty liver fibrosis was induced by high-fat diet combined with intraperitoneal injection of heterologous protein. The results showed that SPJ significantly improved liver function and decreased the serum lipid level. SPJ remarkly decreased the liver steato- sis, collagen fibers and inflammatory cell infiltration. Furthermore, treatment with SPJ significantly downregulated the mRNA level of Collagen Type 1α （COLL 1α）, α-SMA, TIMP, CHOP and GRP78. In addition, SPJ significantly de- creased the protein level of p-JNK, COLL 1α and GRP78. Taken together, SPJ protect against fatty liver fibrosis through inhibition of endoplasmic reticulum stress response and CHOP and JNK-mediated apoptosis and inflammation pathway. These results indicate that SPJ might be a potential drug for prevention of liver fibrosis.展开更多
In this study,we present the characterization of the carbon fibers recovered from the mechanochemical-enhanced recycling of carbon fiber reinforced fibers.The objectives of the study were to investigate the effect of ...In this study,we present the characterization of the carbon fibers recovered from the mechanochemical-enhanced recycling of carbon fiber reinforced fibers.The objectives of the study were to investigate the effect of our modified recycling method on the interfacial properties of recovered fibers.The reinforced plastics were recycled;the recycling efficiency was determined and the recovered fibers were sized using 1 wt%and 3 wt%concentration of(3-aminopropyl)triethoxysilane.We characterized the morphologies utilizing the electron spectroscopy for chemical analysis(ESCA),atomic force microscopy(AFM),FTIR-attenuated total reflection(ATR)spectroscopy and scanning electron microscopy(SEM).Although the surface of the fibers had no cracks,there was evidence of contaminations which affected the interfacial properties and the quality of the fibers.Results showed that the trends in the recovered and virgin fibers were similar with an increase in sizing concentration.The results highlighted the perspectives of increasing the quality of recovered fibers after the recycling process.展开更多
The nanocomposite xCoFe2O4-(1-x)BaTiO3(x=0.2,0.3,0.4,0.5,molar fraction) fibers with fine diameters and high aspect ratios(length to diameter ratios) were prepared by the organic gel-thermal decomposition process from...The nanocomposite xCoFe2O4-(1-x)BaTiO3(x=0.2,0.3,0.4,0.5,molar fraction) fibers with fine diameters and high aspect ratios(length to diameter ratios) were prepared by the organic gel-thermal decomposition process from citric acid and metal salts.The structures and morphologies of gel precursors and fibers derived from thermal decomposition of the gel precursors were characterized by Fourier transform infrared spectroscopy,X-ray diffractometry and scanning electron microscopy.The magnetic properties of the nanocomposite fibers were measured by vibrating sample magnetometer.The nanocomposite fibers consisting of ferrite(CoFe2O4) and perovskite(BaTiO3) are formed at the calcination temperature of 900 ℃ for 2 h.The average grain sizes of CoFe2O4 and BaTiO3 in the nanocomposite fibers increase from 25 to 65 nm with the calcination temperature from 900 to 1 180 ℃.The single fiber constructed from these nanograins of CoFe2O4 and BaTiO3 has a necklace-like morphology.The saturation magnetization of the nanocomposite 0.4CoFe2O4-0.6BaTiO3 fibers increases with the increase of CoFe2O4 grain size,while the coercivity reaches a maximum value when the average grain size of CoFe2O4 is around the critical single-domain size of 45 nm obtained at 1 000 ℃.The saturation magnetization and remanence of the nanocomposite xCoFe2O4-(1-x)BaTiO3(x=0.2,0.3,0.4,0.5) fibers almost exhibit a linear relationship with the molar fraction of CoFe2O4 in the nanocomposites.展开更多
文摘Fatty liver fibrosis, a severe type of Nonalcoholic fatty liver disease （NAFLD）, can be reversed by effec- tive medical intervention. Endoplasmic reticulum stress promotes liver fat accumulation and induction of inflammatory cytokines, which plays an important role in the process of liver fibrosis. Our previous study have shown that, SPJ （saponins of Panax Japonicus） has significant antioxidant and anti-inflammatory activity. Therefore, the protective effects and mechanisms of SPJ against fatty liver fibrosis in mice were investigated. In this study, fatty liver fibrosis was induced by high-fat diet combined with intraperitoneal injection of heterologous protein. The results showed that SPJ significantly improved liver function and decreased the serum lipid level. SPJ remarkly decreased the liver steato- sis, collagen fibers and inflammatory cell infiltration. Furthermore, treatment with SPJ significantly downregulated the mRNA level of Collagen Type 1α （COLL 1α）, α-SMA, TIMP, CHOP and GRP78. In addition, SPJ significantly de- creased the protein level of p-JNK, COLL 1α and GRP78. Taken together, SPJ protect against fatty liver fibrosis through inhibition of endoplasmic reticulum stress response and CHOP and JNK-mediated apoptosis and inflammation pathway. These results indicate that SPJ might be a potential drug for prevention of liver fibrosis.
基金Project(S2598445)supported by the Project for Cooperative R&D between Industry,Academy and Research Institute Funded by the Korea Ministry of SME and Startups in 2018
文摘In this study,we present the characterization of the carbon fibers recovered from the mechanochemical-enhanced recycling of carbon fiber reinforced fibers.The objectives of the study were to investigate the effect of our modified recycling method on the interfacial properties of recovered fibers.The reinforced plastics were recycled;the recycling efficiency was determined and the recovered fibers were sized using 1 wt%and 3 wt%concentration of(3-aminopropyl)triethoxysilane.We characterized the morphologies utilizing the electron spectroscopy for chemical analysis(ESCA),atomic force microscopy(AFM),FTIR-attenuated total reflection(ATR)spectroscopy and scanning electron microscopy(SEM).Although the surface of the fibers had no cracks,there was evidence of contaminations which affected the interfacial properties and the quality of the fibers.Results showed that the trends in the recovered and virgin fibers were similar with an increase in sizing concentration.The results highlighted the perspectives of increasing the quality of recovered fibers after the recycling process.
基金Project(50674048) supported by the National Natural Science Foundation of China Project(20080431069) supported by China Postdoctoral Science FoundationProject(CX10B-257Z) supported by Postgraduate Cultivation and Innovation Foundation of Jiangsu Province,China
文摘The nanocomposite xCoFe2O4-(1-x)BaTiO3(x=0.2,0.3,0.4,0.5,molar fraction) fibers with fine diameters and high aspect ratios(length to diameter ratios) were prepared by the organic gel-thermal decomposition process from citric acid and metal salts.The structures and morphologies of gel precursors and fibers derived from thermal decomposition of the gel precursors were characterized by Fourier transform infrared spectroscopy,X-ray diffractometry and scanning electron microscopy.The magnetic properties of the nanocomposite fibers were measured by vibrating sample magnetometer.The nanocomposite fibers consisting of ferrite(CoFe2O4) and perovskite(BaTiO3) are formed at the calcination temperature of 900 ℃ for 2 h.The average grain sizes of CoFe2O4 and BaTiO3 in the nanocomposite fibers increase from 25 to 65 nm with the calcination temperature from 900 to 1 180 ℃.The single fiber constructed from these nanograins of CoFe2O4 and BaTiO3 has a necklace-like morphology.The saturation magnetization of the nanocomposite 0.4CoFe2O4-0.6BaTiO3 fibers increases with the increase of CoFe2O4 grain size,while the coercivity reaches a maximum value when the average grain size of CoFe2O4 is around the critical single-domain size of 45 nm obtained at 1 000 ℃.The saturation magnetization and remanence of the nanocomposite xCoFe2O4-(1-x)BaTiO3(x=0.2,0.3,0.4,0.5) fibers almost exhibit a linear relationship with the molar fraction of CoFe2O4 in the nanocomposites.
