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基于系统性炎症指标构建的列线图可预测心力衰竭患者的不良结局 被引量:5
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作者 刘昭君 周晓莉 《南方医科大学学报》 CAS CSCD 北大核心 2022年第8期1149-1158,共10页
目的基于系统性炎症指标,构建列线图评估心力衰竭患者不良结局的风险。方法回顾性分析2017年6月~2019年6月在重庆医科大学附属第一医院心血管内科住院的430例心力衰竭患者的临床资料。将患者按照7∶3比例随机分为建模组(n=286)和验证组(... 目的基于系统性炎症指标,构建列线图评估心力衰竭患者不良结局的风险。方法回顾性分析2017年6月~2019年6月在重庆医科大学附属第一医院心血管内科住院的430例心力衰竭患者的临床资料。将患者按照7∶3比例随机分为建模组(n=286)和验证组(n=144),采用COX回归分析筛选心力衰竭预后的危险因素,并构建列线图。使用校准曲线评估列线图的预测准确性,使用决策曲线分析(DCA)和Kaplan-Meier曲线评估列线图的临床实用性。结果多因素COX回归分析结果显示,年龄(P=0.03)、体质量指数(BMI,P=0.002)、纽约心功能分级(NYHA分级,P<0.001)、高血压(P=0.004)、淋巴细胞计数(P<0.001)、血小板淋巴细胞计数(PLR,P=0.007)、中性粒细胞淋巴细胞计数(NLR,P<0.001)和系统炎症反应指数(SIRI,P<0.001)是心力衰竭的独立预后因子。利用这些预后危险因素构建列线图,结果显示其预测性能良好:在建模组和验证组中,列线图C指数分别为0.719(95%CI:0.680~0.758)和0.732(95%CI:0.693~0.771)。校准曲线显示,该模型在预测HF患者的不良结局方面(心血管再入院或全因死亡)具有较好的一致性。结论联合系统性炎症指标和传统危险因素构建的列线图在HF患者不良结局预测方面性能良好。 展开更多
关键词 心力衰竭 预后 系统性炎症指标 列线图
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可持续发展指标体系及综合评价研究评述 被引量:11
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作者 邱茂慧 陈忠暖 蔡霞 《热带地理》 2002年第3期222-226,共5页
可持续发展指标体系研究和可持续发展综合评价研究是可持续发展进程的一部分,是连接可持续发展战略理论与战略实施的桥梁,文中对近年来国内外出现的有关研究做了简要概括,分析了各研究成果的优缺点,总结了研究的发展特点并展望了研究的... 可持续发展指标体系研究和可持续发展综合评价研究是可持续发展进程的一部分,是连接可持续发展战略理论与战略实施的桥梁,文中对近年来国内外出现的有关研究做了简要概括,分析了各研究成果的优缺点,总结了研究的发展特点并展望了研究的前景。 展开更多
关键词 可持续发展 指标体系 综合评价 国民生产总值指标 系统性指标
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男性原发骨质疏松症骨密度与新型炎症指标的相关性 被引量:13
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作者 周泽霖 尚奇 +7 位作者 卓航 黄宏伟 龚焱 张丹 李兵 梁德 任辉 江晓兵 《中国骨质疏松杂志》 CAS CSCD 北大核心 2023年第5期636-640,646,共6页
目的 了解系统性炎症相关指标及其他炎症指标水平与男性原发性骨质疏松症患者骨密度(bone mineral density, BMD)值的相关性。方法 筛选出2021年1月至2022年5月在广州中医药大学第一附属医院符合纳入标准与排除标准的男性患者,共311例... 目的 了解系统性炎症相关指标及其他炎症指标水平与男性原发性骨质疏松症患者骨密度(bone mineral density, BMD)值的相关性。方法 筛选出2021年1月至2022年5月在广州中医药大学第一附属医院符合纳入标准与排除标准的男性患者,共311例。根据诊断标准将患者分为骨质疏松组、骨量减少组以及骨量正常组并进行回顾性研究。结果 骨质疏松组中SII、NLR、MLR以及ESR明显高于骨量正常组,差异有统计学意义(P<0.05)。二元Logistics回归分析发现PLR(P<0.05)与ESR(P<0.05)为男性发生原发性骨质疏松的危险因素。受试者工作特征(receiver operating characteristic, ROC)曲线显示PLR曲线下面积为0.658,临界值为189.17;ESR的曲线下面积为0.639,临界值为18.50;多指标联合曲线下面积为0.713。在男性原发性骨质疏松症患者中对不同部位骨密度与炎症指标进行相关性分析,结果表明除MLR与L1~L4 BMD无明显相关性,SII、NLR、PLR、CRP、ESR与L1~L4 BMD呈负相关,且差异有统计学意义(P<0.05)。另外,SII、NLR、MLR、PLR、CRP、ESR与左股骨颈骨密度以及左髋关节骨密度呈负相关,且差异有统计学意义(P<0.05)。结论 男性原发性骨质疏松症患者的骨密度与SII、NLR、MLR、PLR、CRP、ESR等炎症指标具有相关性。 展开更多
关键词 男性 原发性骨质疏松症 骨密度 系统性炎症指标
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Integrating unascertained measurement and information entropy theory to assess blastability of rock mass 被引量:15
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作者 周健 李夕兵 《Journal of Central South University》 SCIE EI CAS 2012年第7期1953-1960,共8页
Due to the complex features of rock mass blastability assessment systems, an evaluation model of rock mass blastability was established on the basis of the unascertained measurement (UM) theory and the actual charac... Due to the complex features of rock mass blastability assessment systems, an evaluation model of rock mass blastability was established on the basis of the unascertained measurement (UM) theory and the actual characteristics of the project. Considering a comprehensive range of intact rock properties and discontinuous structures of rock mass, twelve main factors influencing the evaluation blastability of rock mass were taken into account in the UM model, and the blastability evaluation index system of rock mass was constructed. The unascertained evaluation indices corresponding to the selected factors for the actual situation were solved both qualitatively and quantitatively. Then, the UM function of each evaluation index was obtained based on the initial data for the analysis of the blastability of six rock mass at a highway improvement cutting site in North Wales. The index weights of the factors were calculated by entropy theory, and credible degree identification (CDI) criteria were established according to the UM theory. The results of rock mass blastability evaluation were obtained by the CDI criteria. The results show that the UM model assessment results agree well with the actual records, and are consistent with those of the fuzzy sets evaluation method. Meanwhile, the unascertained superiority degree of rock mass blastability of samples S1-$6 which can be calculated by scoring criteria are 3.428 5, 3.453 3, 4.058 7, 3.675 9, 3.516 7 and 3.289 7, respectively. Furthermore, the proposed method can take into account large amount of uncertain information in blastability evaluation, which can provide an effective, credible and feasible way for estimating the blastability of rock mass. Engineering practices show that it can complete the blastability assessment systematically and scientifically without any assumption by the proposed model, which can be applied to practical engineering. 展开更多
关键词 rock mass BLASTABILITY unascertained measurement (UM) model information entropy PREDICTION
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Guaranteed cost sampled-data control for uncertain nonlinear time-varying delay system 被引量:1
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作者 樊丽颖 武俊峰 《Journal of Central South University》 SCIE EI CAS 2011年第6期2056-2060,共5页
The robust guaranteed cost sampled-data control was studied for a class of uncertain nonlinear systems with time-varying delay. The parameter uncertainties are time-varying norm-bounded and appear in both the state an... The robust guaranteed cost sampled-data control was studied for a class of uncertain nonlinear systems with time-varying delay. The parameter uncertainties are time-varying norm-bounded and appear in both the state and the input control matrices. By applying an input delay approach, the system was transformed into a continuous time-delay system. Attention was focused on the design of a robust guaranteed cost sampled-data control law which guarantees that the closed-loop system is asymptotically stable and the quadratic performance index is less than a certain bound for all admissible uncertainties. By applying Lyapunov stability theory, the theorems were derived to provide sufficient conditions for the existence of robust guaranteed cost sampled-data control law in the form of linear matrix inequalities (LMIs), especially an optimal state-feedback guaranteed cost sampled-data control law which ensures the minimization of the guaranteed cost was given. The effectiveness of the proposed method was illustrated by a simulation example with the asymptotically stable curves of system state under the initial condition of x(0)=[0.679 6 0]. 展开更多
关键词 nonlinear system guaranteed cost sampled-data control input delay linear matrix inequalities
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