Future manufacturing systems need to cope with frequent changes and disturbances, therefore their control architectures require constant adaptability, agility, stability, self-organization, intelligence, and robustnes...Future manufacturing systems need to cope with frequent changes and disturbances, therefore their control architectures require constant adaptability, agility, stability, self-organization, intelligence, and robustness. Bio-inspired manufacturing system can well satisfy these requirements. For this purpose, by referencing the biological organization structure and the mechanism, a bio-inspired manufacturing cell is presented from a novel view, and then a bio-inspired self-adaptive manufacturing model is established based on the ultra-short feedback mechanism of the neuro-endocrine system. A hio-inspired self-adaptive manufacturing system coordinated model is also established based on the neuro-endocrine-immunity system （NEIS）. Finally, an example based on pheromone communication mechanism indicates that the robustness of the whole manufacturing system is improved by bio-inspired technologies.展开更多
This paper investigates the problem of the model validation in identifying discrete-time-nonlinear dynamic systems by using neural networks with a single hidden layer.Based on the estimation theory,a synthetic error-i...This paper investigates the problem of the model validation in identifying discrete-time-nonlinear dynamic systems by using neural networks with a single hidden layer.Based on the estimation theory,a synthetic error-index(SEI)criterion for the neural network models has been developed.By using the powerful training algorithm of recursive prediction error (RPE),two simulated non-linear systems are studied,and the results show that the synthetic error-index criterion can be used to verify the dynamic neural network models.Furthermore,the proposed technique is much simple in calculation than that of the effective correlation tests.Finally,some problems required by further study are discussed.展开更多
In this paper, Neural Networks （NNs） are used in the modeling of ship maneuvering motion. A nonlinear response model and a linear hydrodynamic model of ship maneuvering motion are also investigated. The maneuverabil...In this paper, Neural Networks （NNs） are used in the modeling of ship maneuvering motion. A nonlinear response model and a linear hydrodynamic model of ship maneuvering motion are also investigated. The maneuverability indices and linear non-dimensional hydrodynamic derivatives in the models are identified by using two-layer feed forward NNs. The stability of parametric estimation is confirmed. Then, the ship maneuvering motion is predicted based on the obtained models. A comparison between the predicted results and the model test results demonstrates the validity of the proposed modeling method.展开更多
Microglial activation plays an important role in a panel of neurological disorders such as multiple sclerosis(MS) and Parkinson's disease(PD),and is a key target for developing therapeutic strategies for these dis...Microglial activation plays an important role in a panel of neurological disorders such as multiple sclerosis(MS) and Parkinson's disease(PD),and is a key target for developing therapeutic strategies for these diseases.Ketogenic diet (KD),which is able to inhibit microglial activation in substantia nigra pars compacta of mice,has been shown effective in a mouse model of PD,possibly through increasing D-β-hydroxybutyrate(D-β-HB),a major component of ketone bodies.To verify this,we developed an in vitro model of microglia activation with a microglia line,BV-2,and investigated how D-β-HB have an effect on the LPS-stimulated BV-2 cells.We found D-β-HB is able to recover the cell viability,and inhibit the production of inflammatory mediators and cytokines such as ROS,nitrite,IL-1β,TNF-α,and IL-6,which otherwise were increased in LPS-stimulated BV-2 cells.We conclude that the LPS induced BV-2 cells activation is a valid in vitro model of microglia activation.D-β-HB is able to suppress the activation of BV-2 cells, which might account for one of the possible reasons of KD therapy on the PD model.展开更多
The distribution of the immediate early gene c-fos expression in the mouse central nervous system after subcutaneous injection of Bay K 8644 was observed immunohistochemically. Half an hour after injection, cfos prote...The distribution of the immediate early gene c-fos expression in the mouse central nervous system after subcutaneous injection of Bay K 8644 was observed immunohistochemically. Half an hour after injection, cfos protein (FOS) was expressed in the piriform cortex, sensorimotor cortex, caudate putamen, thalamic paraventricular nucleus and striate cortex,etc. Intense FOS immunoreactive (FOS-ir) cells were seen during 2 ～ 4 h after injection. The restllts suggested that the distribution of FOS-ir ce1ls after subcutaneous injection of Bay K 8644 was coincldent with that of L-type calcium channels in the different areas of the CNS. After Bay K 8644 injection, mice appeared seizure-like behavior. The percentage of cells double-labelled by FOS and CaBP immunoreactivities in the observed regions was about 60. 2～72. 8% in CaBP-ir cells. It suggested that most CaBP-lr cells may have L-type calcium channels.展开更多
基金Supported by the National Natural Science Foundation of China (50505017)Fok Ying Tung Edu-cation Foundation (111056)+1 种基金the Innovative and Excellent Foundation for Doctoral Dissertation of Nanjing University of Aeronautics and Astronautics (BCXJ08-07)the New Century Excellent Talents in University,China (NCET-08)~~
文摘Future manufacturing systems need to cope with frequent changes and disturbances, therefore their control architectures require constant adaptability, agility, stability, self-organization, intelligence, and robustness. Bio-inspired manufacturing system can well satisfy these requirements. For this purpose, by referencing the biological organization structure and the mechanism, a bio-inspired manufacturing cell is presented from a novel view, and then a bio-inspired self-adaptive manufacturing model is established based on the ultra-short feedback mechanism of the neuro-endocrine system. A hio-inspired self-adaptive manufacturing system coordinated model is also established based on the neuro-endocrine-immunity system （NEIS）. Finally, an example based on pheromone communication mechanism indicates that the robustness of the whole manufacturing system is improved by bio-inspired technologies.
文摘This paper investigates the problem of the model validation in identifying discrete-time-nonlinear dynamic systems by using neural networks with a single hidden layer.Based on the estimation theory,a synthetic error-index(SEI)criterion for the neural network models has been developed.By using the powerful training algorithm of recursive prediction error (RPE),two simulated non-linear systems are studied,and the results show that the synthetic error-index criterion can be used to verify the dynamic neural network models.Furthermore,the proposed technique is much simple in calculation than that of the effective correlation tests.Finally,some problems required by further study are discussed.
基金Partially Supported by the Special Item for the Fujian Provincial Department of Ocean and Fisheries(No.MHGX-16)the Special Item for Universities in Fujian Province by the Education Department(No.JK15003)
文摘In this paper, Neural Networks （NNs） are used in the modeling of ship maneuvering motion. A nonlinear response model and a linear hydrodynamic model of ship maneuvering motion are also investigated. The maneuverability indices and linear non-dimensional hydrodynamic derivatives in the models are identified by using two-layer feed forward NNs. The stability of parametric estimation is confirmed. Then, the ship maneuvering motion is predicted based on the obtained models. A comparison between the predicted results and the model test results demonstrates the validity of the proposed modeling method.
文摘Microglial activation plays an important role in a panel of neurological disorders such as multiple sclerosis(MS) and Parkinson's disease(PD),and is a key target for developing therapeutic strategies for these diseases.Ketogenic diet (KD),which is able to inhibit microglial activation in substantia nigra pars compacta of mice,has been shown effective in a mouse model of PD,possibly through increasing D-β-hydroxybutyrate(D-β-HB),a major component of ketone bodies.To verify this,we developed an in vitro model of microglia activation with a microglia line,BV-2,and investigated how D-β-HB have an effect on the LPS-stimulated BV-2 cells.We found D-β-HB is able to recover the cell viability,and inhibit the production of inflammatory mediators and cytokines such as ROS,nitrite,IL-1β,TNF-α,and IL-6,which otherwise were increased in LPS-stimulated BV-2 cells.We conclude that the LPS induced BV-2 cells activation is a valid in vitro model of microglia activation.D-β-HB is able to suppress the activation of BV-2 cells, which might account for one of the possible reasons of KD therapy on the PD model.
文摘The distribution of the immediate early gene c-fos expression in the mouse central nervous system after subcutaneous injection of Bay K 8644 was observed immunohistochemically. Half an hour after injection, cfos protein (FOS) was expressed in the piriform cortex, sensorimotor cortex, caudate putamen, thalamic paraventricular nucleus and striate cortex,etc. Intense FOS immunoreactive (FOS-ir) cells were seen during 2 ～ 4 h after injection. The restllts suggested that the distribution of FOS-ir ce1ls after subcutaneous injection of Bay K 8644 was coincldent with that of L-type calcium channels in the different areas of the CNS. After Bay K 8644 injection, mice appeared seizure-like behavior. The percentage of cells double-labelled by FOS and CaBP immunoreactivities in the observed regions was about 60. 2～72. 8% in CaBP-ir cells. It suggested that most CaBP-lr cells may have L-type calcium channels.
