【据Journal of Hepatology 2021年4月报道】药物性肝损伤恢复期长与发病时高胆红素、高碱性磷酸酶及药物代谢相关(作者Ashby K等)尽管大多数药物性肝损伤(DILI)在停止使用致病药物后预后良好,但患者的恢复期各不相同,6%~12%的患者会发...【据Journal of Hepatology 2021年4月报道】药物性肝损伤恢复期长与发病时高胆红素、高碱性磷酸酶及药物代谢相关(作者Ashby K等)尽管大多数药物性肝损伤(DILI)在停止使用致病药物后预后良好,但患者的恢复期各不相同,6%~12%的患者会发生慢性化。基于此,该研究调查了决定DILI恢复时间的潜在危险因素如临床因素和药物特性,并开发出预测DILI恢复时间的模型。展开更多
A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB...A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB4R), victoria blue B(VBB) and night blue(NB) in weak acid medium. The reduction in absorbance was directly proportional to the concentration of heparin. The linear ranges of heparin were from 0 to 2.4 μg/mL for all systems. The molar absorptivities( ε ) of the three systems were between 2.11×10 6 and 2.66×10 6 L·mol -1 ·cm -1 and the sensitivity of VB4R system was the highest. Taking VB4R system for an example, the effects of some coexisting substances on the determination of heparin have been investigated and the results showed that the method had a good selectivity. The method has been applied to determination of the heparin samples with satisfactory results.展开更多
文摘【据Journal of Hepatology 2021年4月报道】药物性肝损伤恢复期长与发病时高胆红素、高碱性磷酸酶及药物代谢相关(作者Ashby K等)尽管大多数药物性肝损伤(DILI)在停止使用致病药物后预后良好,但患者的恢复期各不相同,6%~12%的患者会发生慢性化。基于此,该研究调查了决定DILI恢复时间的潜在危险因素如临床因素和药物特性,并开发出预测DILI恢复时间的模型。
文摘A new spectrophotometric method for the determination of trace heparin has been studied. The method was based on the discoloration reaction between heparin and bisphenylnaphthylmethane dyes such as victoria blue 4R(VB4R), victoria blue B(VBB) and night blue(NB) in weak acid medium. The reduction in absorbance was directly proportional to the concentration of heparin. The linear ranges of heparin were from 0 to 2.4 μg/mL for all systems. The molar absorptivities( ε ) of the three systems were between 2.11×10 6 and 2.66×10 6 L·mol -1 ·cm -1 and the sensitivity of VB4R system was the highest. Taking VB4R system for an example, the effects of some coexisting substances on the determination of heparin have been investigated and the results showed that the method had a good selectivity. The method has been applied to determination of the heparin samples with satisfactory results.
