2024年11月7日,Cancer Cell期刊在线发表了题为“Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy”的研究论文。该论文由上海交通大学医学院附属仁济医院-上海市肿瘤研究所覃文新/王存团队...2024年11月7日,Cancer Cell期刊在线发表了题为“Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy”的研究论文。该论文由上海交通大学医学院附属仁济医院-上海市肿瘤研究所覃文新/王存团队,复旦大学附属中山医院高强教授团队,上海交通大学公共卫生学院、上海交通大学医学院单细胞组学与疾病研究中心助理研究员郑铨以及德国癌症研究中心孙崇教授合作完成。该研究结合类器官与单细胞多组学技术,全面探讨了多种肿瘤干细胞标志物分子,发现高表达CD49f的肝癌细胞通过CXCL2-CXCR2招募中性粒细胞,形成独特的免疫抑制微环境。这些中性粒细胞通过分泌CCL4进一步维持肿瘤起始细胞的性征,并赋予其“免疫特权”,使其能够通过表达CD155逃避CD8+T细胞的免疫攻击。展开更多
Cancer Research Institute of Central South University (CRI-CSU) was founded in 1989. Following its foundation in 1989, CRI-CSU has been established into State Key Discipline of Pathophysiology since 1990, the Postdoct...Cancer Research Institute of Central South University (CRI-CSU) was founded in 1989. Following its foundation in 1989, CRI-CSU has been established into State Key Discipline of Pathophysiology since 1990, the Postdoctoral Training Station of Basic Medicine since 1991, Key Laboratory of Carcinogenesis of Ministry of Public Health since 1994, and Key Laboratory of Carcinogenesis and Invasion of Ministry of Education since 2000. The professorship of Cheung Kong Scholars Programm by special appointment has also been established at CRI-CSL' since 2000.展开更多
文摘2024年11月7日,Cancer Cell期刊在线发表了题为“Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy”的研究论文。该论文由上海交通大学医学院附属仁济医院-上海市肿瘤研究所覃文新/王存团队,复旦大学附属中山医院高强教授团队,上海交通大学公共卫生学院、上海交通大学医学院单细胞组学与疾病研究中心助理研究员郑铨以及德国癌症研究中心孙崇教授合作完成。该研究结合类器官与单细胞多组学技术,全面探讨了多种肿瘤干细胞标志物分子,发现高表达CD49f的肝癌细胞通过CXCL2-CXCR2招募中性粒细胞,形成独特的免疫抑制微环境。这些中性粒细胞通过分泌CCL4进一步维持肿瘤起始细胞的性征,并赋予其“免疫特权”,使其能够通过表达CD155逃避CD8+T细胞的免疫攻击。
文摘Cancer Research Institute of Central South University (CRI-CSU) was founded in 1989. Following its foundation in 1989, CRI-CSU has been established into State Key Discipline of Pathophysiology since 1990, the Postdoctoral Training Station of Basic Medicine since 1991, Key Laboratory of Carcinogenesis of Ministry of Public Health since 1994, and Key Laboratory of Carcinogenesis and Invasion of Ministry of Education since 2000. The professorship of Cheung Kong Scholars Programm by special appointment has also been established at CRI-CSL' since 2000.