Objective To explore the effect of inflammation and autoimmunity in peripartum cardiomyopathy （PPCM）. Methods A total of 82 PPCM patients and 100 normal delivery patients were randomly selected and conducted epidemi...Objective To explore the effect of inflammation and autoimmunity in peripartum cardiomyopathy （PPCM）. Methods A total of 82 PPCM patients and 100 normal delivery patients were randomly selected and conducted epidemiological survey. High-sensitivity C- reaction protein （hs-CRP）, troponin I, human antimyocardial antibody IgG （AMA-IgG）, Coxsackie B virus IgG （CBV-IgG） and adenovirus antibody IgG （ADV- IgG） were detected with ELISA. Results Compared with control group, PPCM patients had older age, higher pressure, higher proportion of cesarean section and infection. The levels of serum hs-CRP, cTNI, and leucocyte were markedly higher in PPCM patients compared with control. The positive proportion of AMA-IgG and CBV-IgG was signifi- cantly increased （P〈0.01） in PPCM patients compared with the control. Logistic regression showed that infection （OR=2.87, 95%CI 1.15-5.24）, increased hs-CRP （OR=1.86, 95%CI 1.08-4.02） and positive AMA-IgG （OR=2.68, 95%CI 1.19-4.85） were independent risk factors for PPCM. Conclusions Inflammation and autoimmunity play an important role in peripartum cardiomyopathy（J Geriatr Cardio12010; 7：106-109）.展开更多
文摘Objective To explore the effect of inflammation and autoimmunity in peripartum cardiomyopathy （PPCM）. Methods A total of 82 PPCM patients and 100 normal delivery patients were randomly selected and conducted epidemiological survey. High-sensitivity C- reaction protein （hs-CRP）, troponin I, human antimyocardial antibody IgG （AMA-IgG）, Coxsackie B virus IgG （CBV-IgG） and adenovirus antibody IgG （ADV- IgG） were detected with ELISA. Results Compared with control group, PPCM patients had older age, higher pressure, higher proportion of cesarean section and infection. The levels of serum hs-CRP, cTNI, and leucocyte were markedly higher in PPCM patients compared with control. The positive proportion of AMA-IgG and CBV-IgG was signifi- cantly increased （P〈0.01） in PPCM patients compared with the control. Logistic regression showed that infection （OR=2.87, 95%CI 1.15-5.24）, increased hs-CRP （OR=1.86, 95%CI 1.08-4.02） and positive AMA-IgG （OR=2.68, 95%CI 1.19-4.85） were independent risk factors for PPCM. Conclusions Inflammation and autoimmunity play an important role in peripartum cardiomyopathy（J Geriatr Cardio12010; 7：106-109）.
