目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM...目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM和IR分析结果显示白头翁总皂苷和Eudragit S100形成了固体分散体。体外释放度结果显示载药量在20%时指标成分在p H 1.0溶液中2 h基本不释放,在p H 6.8溶液中4 h累积释放度小于16%,在p H 7.8溶液中2 h累积释放大于86%。结论所制备的固体分散体达到了结肠定位的效果。展开更多
Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology.In addition to the topographic imaging,its capability of localized delivery of bio-active molecules is emerging.In this ...Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology.In addition to the topographic imaging,its capability of localized delivery of bio-active molecules is emerging.In this mini review,we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery.The working principles of three delivery modes including resistive pulse,pressure-driven flow,and electroosmotic flow-driven delivery are summarized and compared.Their applications in single-cell researches are reviewed.The current technical challenges in scanning ion conductance microscopy-based delivery,and their growing influence in medicine and pharmacologic researches are also discussed.展开更多
The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical app...The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical approach.The sub - micronic grains uniformly covering the gold plate was evidenced by scanning electron microscope(SEM).The film of charge - transfer salt exhibits semiconducting behavior with a room - temperature conductivity4.8 × 10 -3 S·cm -1 .展开更多
A large scale Palladium nanowire array was directly grown on the surface of glassy carbon electrode by direct current electrolysis with the help of anodic aluminum oxide template.High-resolved SEM photographs have ind...A large scale Palladium nanowire array was directly grown on the surface of glassy carbon electrode by direct current electrolysis with the help of anodic aluminum oxide template.High-resolved SEM photographs have indicated that the Palladium nanowire arrays were highly uniform and ordered.The diameter of single Pd nanowire was about 30 nm,which agreed well with the porous diameter of used template.Meanwhile,the electrocatalytic activity of Pd NWAs electrodes for ethanol oxidation in alkaline media was studied.It is found that the obtained nanostructurs exhibit excellent catalytic activity for ethanol.展开更多
文摘目的制备白头翁总皂苷结肠定位固体分散体。方法采用溶剂法制备白头翁总皂苷固体分散体,以体外累计释放度为评价指标,采用单因素方法筛选制备工艺及处方,并采用电子扫描显微镜(SEM)、红外光谱(IR)对制备的固体分散体进行分析。结果 SEM和IR分析结果显示白头翁总皂苷和Eudragit S100形成了固体分散体。体外释放度结果显示载药量在20%时指标成分在p H 1.0溶液中2 h基本不释放,在p H 6.8溶液中4 h累积释放度小于16%,在p H 7.8溶液中2 h累积释放大于86%。结论所制备的固体分散体达到了结肠定位的效果。
基金support from the National Institute of General Medical Sciences(1R35G M147172-01).
文摘Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology.In addition to the topographic imaging,its capability of localized delivery of bio-active molecules is emerging.In this mini review,we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery.The working principles of three delivery modes including resistive pulse,pressure-driven flow,and electroosmotic flow-driven delivery are summarized and compared.Their applications in single-cell researches are reviewed.The current technical challenges in scanning ion conductance microscopy-based delivery,and their growing influence in medicine and pharmacologic researches are also discussed.
文摘The conducting thin film of charge - transfer salt based upon polyoxometalate[VW 5 O 19 ] 3- and bis(ethyl - enedithio) - tetrathiafulvalene(BEDT - TTF or ET)was fabricated on the gold substrate by electrochemical approach.The sub - micronic grains uniformly covering the gold plate was evidenced by scanning electron microscope(SEM).The film of charge - transfer salt exhibits semiconducting behavior with a room - temperature conductivity4.8 × 10 -3 S·cm -1 .
文摘A large scale Palladium nanowire array was directly grown on the surface of glassy carbon electrode by direct current electrolysis with the help of anodic aluminum oxide template.High-resolved SEM photographs have indicated that the Palladium nanowire arrays were highly uniform and ordered.The diameter of single Pd nanowire was about 30 nm,which agreed well with the porous diameter of used template.Meanwhile,the electrocatalytic activity of Pd NWAs electrodes for ethanol oxidation in alkaline media was studied.It is found that the obtained nanostructurs exhibit excellent catalytic activity for ethanol.
