为探究莲原花青素低聚体(oligomeric procyanidins of lotus seedpod,LSOPC)在模拟生理环境下对非酶糖化末端产物(advanced glycation end products,AGEs)的抑制作用,测定金属离子、高糖和高蛋白质量浓度条件下LSOPC对体外AGEs的抑制率...为探究莲原花青素低聚体(oligomeric procyanidins of lotus seedpod,LSOPC)在模拟生理环境下对非酶糖化末端产物(advanced glycation end products,AGEs)的抑制作用,测定金属离子、高糖和高蛋白质量浓度条件下LSOPC对体外AGEs的抑制率,以及固定比例法评价LSOPC与表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)复配物对体外AGEs生成的抑制作用。结果表明:在模拟生理环境下,AGEs体外孵育最适反应时间为35 d,LSOPC的抑制效果达到最大值。不同质量浓度的金属离子(Cu^(2+)、Fe^(2+)、Zn^(2+)、Ca^(2+)、Mg^(2+)、Al^(3+)、Sn^(2+))对体外AGEs生成的影响各不相同,其中Cu^(2+)和Fe^(2+)在模拟体系中AGEs生成的促进作用最强,但和LSOPC一起有协同抑制作用;其他5种金属离子对AGEs生成都有不同程度的抑制或促进作用,但对LSOPC对AGEs的抑制作用几乎无影响。在高糖高蛋白反应体系中,发现LSOPC在高糖、高蛋白以及单独高蛋白情况下,抑制效果最差。LSOPC与EGCG复配有协同抑制AGEs效果,并且在LSOPC与EGCG质量浓度比为2∶1时最佳。展开更多
Strategic environment assessment (SEA) and ecosystem health are two new ideas on environmental management. On the basis of reviewing some relevant literature, this paper made discussions on the ecological sustainabili...Strategic environment assessment (SEA) and ecosystem health are two new ideas on environmental management. On the basis of reviewing some relevant literature, this paper made discussions on the ecological sustainability target of SEA, the content of ecosystem health as well as the interrelations between SEA and ecosystem health. For a good SEA, its ecological sustainability principles should be provided with distinct content and a general assessment system. A framework for ecosystem health assessment was established according to the content of ecosystem health, and combined into SEA as SEA抯 ecological sustainability target, we can effectively guide decision-makers to make suitable indigenous means and local solutions. , The basic principles and procedure of SEA for ecosystem health are also discussed in the paper.展开更多
据Ochi K 2021年6月11日[Nat Commun,2021,12(1):3568-3568.]报道,日本东京大学、筑波大学和英国牛津大学的研究人员开发出一种新的技术,有可能克服与这些称为骨髓(BM)嵌合小鼠的模型相关的限制。该方法允许研究人员观察和研究基因改变...据Ochi K 2021年6月11日[Nat Commun,2021,12(1):3568-3568.]报道,日本东京大学、筑波大学和英国牛津大学的研究人员开发出一种新的技术,有可能克服与这些称为骨髓(BM)嵌合小鼠的模型相关的限制。该方法允许研究人员观察和研究基因改变如何影响生理环境中的免疫细胞表型和行为。展开更多
文摘为探究莲原花青素低聚体(oligomeric procyanidins of lotus seedpod,LSOPC)在模拟生理环境下对非酶糖化末端产物(advanced glycation end products,AGEs)的抑制作用,测定金属离子、高糖和高蛋白质量浓度条件下LSOPC对体外AGEs的抑制率,以及固定比例法评价LSOPC与表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)复配物对体外AGEs生成的抑制作用。结果表明:在模拟生理环境下,AGEs体外孵育最适反应时间为35 d,LSOPC的抑制效果达到最大值。不同质量浓度的金属离子(Cu^(2+)、Fe^(2+)、Zn^(2+)、Ca^(2+)、Mg^(2+)、Al^(3+)、Sn^(2+))对体外AGEs生成的影响各不相同,其中Cu^(2+)和Fe^(2+)在模拟体系中AGEs生成的促进作用最强,但和LSOPC一起有协同抑制作用;其他5种金属离子对AGEs生成都有不同程度的抑制或促进作用,但对LSOPC对AGEs的抑制作用几乎无影响。在高糖高蛋白反应体系中,发现LSOPC在高糖、高蛋白以及单独高蛋白情况下,抑制效果最差。LSOPC与EGCG复配有协同抑制AGEs效果,并且在LSOPC与EGCG质量浓度比为2∶1时最佳。
文摘Strategic environment assessment (SEA) and ecosystem health are two new ideas on environmental management. On the basis of reviewing some relevant literature, this paper made discussions on the ecological sustainability target of SEA, the content of ecosystem health as well as the interrelations between SEA and ecosystem health. For a good SEA, its ecological sustainability principles should be provided with distinct content and a general assessment system. A framework for ecosystem health assessment was established according to the content of ecosystem health, and combined into SEA as SEA抯 ecological sustainability target, we can effectively guide decision-makers to make suitable indigenous means and local solutions. , The basic principles and procedure of SEA for ecosystem health are also discussed in the paper.
文摘据Ochi K 2021年6月11日[Nat Commun,2021,12(1):3568-3568.]报道,日本东京大学、筑波大学和英国牛津大学的研究人员开发出一种新的技术,有可能克服与这些称为骨髓(BM)嵌合小鼠的模型相关的限制。该方法允许研究人员观察和研究基因改变如何影响生理环境中的免疫细胞表型和行为。
