Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inf...Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid （UA） metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical charac- teristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure （n = 553）. By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid （SUA） formed part of a principal cluster of renal functional variables which included serum creatinine （SCr） and blood urea nitrogen （BUN）. Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN （r = 0.48, P 〈 0.001） and SCr （r = 0.47, P 〈 0.001）. Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.展开更多
Wind power has made rapid progress and should gain significance as an energy resource,given growing interest in renewable energy and clean energy.Offshore wind energy resources have attracted significant attention,as,...Wind power has made rapid progress and should gain significance as an energy resource,given growing interest in renewable energy and clean energy.Offshore wind energy resources have attracted significant attention,as,compared with land-based wind energy resources,offshore wind energy resources are more promising candidates for development.Sea winds are generally stronger and more reliable and with improvements in technology,the sea has become a hot spot for new designs and installation methods for wind turbines.In the present paper,based on experience building offshore wind farms,recommended foundation styles have been examined.Furthermore,wave effects have been investigated.The split installation and overall installation have been illustrated.Methods appropriate when installing a small number of turbines as well as those useful when installing large numbers of turbines were analyzed.This investigation of installation methods for wind turbines should provide practical technical guidance for their installation.展开更多
文摘Background Hyperuricemia is frequently present in patients with heart failure. Many pathological conditions, such as tissue ischemia, renal function impairment, cardiac function impairment, metabolic syndrome, and inflammatory status, may impact uric acid （UA） metabolism. This study was to assess their potential relations to UA metabolism in heart failure. Methods We retrospectively assessed clinical charac- teristics, echocardiological, renal, metabolic and inflammatory variables selected on the basis of previous evidence of their involvement in cardiovascular diseases and UA metabolism in a large cohort of randomly selected adults with congestive heart failure （n = 553）. By clustering of indices, those variables were explored using factor analysis. Results In factor analysis, serum uric acid （SUA） formed part of a principal cluster of renal functional variables which included serum creatinine （SCr） and blood urea nitrogen （BUN）. Univariate correlation coefficients between variables of patients with congestive heart failure showed that the strongest correlations for SUA were with BUN （r = 0.48, P 〈 0.001） and SCr （r = 0.47, P 〈 0.001）. Conclusions There was an inverse relationship between SUA levels and measures of renal function in patients with congestive heart failure. The strong correlation between SUA and SCr and BUN levels suggests that elevated SUA concentrations reflect an impairment of renal function in heart failure.
基金Supported by 111 Project Foundation under Grant No.B07019the National Natural Science Foundation of China under Grand No.50979020
文摘Wind power has made rapid progress and should gain significance as an energy resource,given growing interest in renewable energy and clean energy.Offshore wind energy resources have attracted significant attention,as,compared with land-based wind energy resources,offshore wind energy resources are more promising candidates for development.Sea winds are generally stronger and more reliable and with improvements in technology,the sea has become a hot spot for new designs and installation methods for wind turbines.In the present paper,based on experience building offshore wind farms,recommended foundation styles have been examined.Furthermore,wave effects have been investigated.The split installation and overall installation have been illustrated.Methods appropriate when installing a small number of turbines as well as those useful when installing large numbers of turbines were analyzed.This investigation of installation methods for wind turbines should provide practical technical guidance for their installation.
