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高效液相色谱法测定海力特胶囊含量及体外溶出度
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作者 吕志华 赵峡 《青岛海洋大学学报(自然科学版)》 CSCD 北大核心 2002年第2期241-244,共4页
本文建立了测定海力特胶囊含量和体外溶出度的高效液相色谱方法。采用 Aminex HPX-87H(30 0 mm× 7.8mm)柱 ,以 0 .0 0 2 5 mol· L-1H2 SO4 为流动相 ,柱温为 6 5℃ ,流速为 0 .5 m L·min-1,以示差检测器检测 ,外标法峰... 本文建立了测定海力特胶囊含量和体外溶出度的高效液相色谱方法。采用 Aminex HPX-87H(30 0 mm× 7.8mm)柱 ,以 0 .0 0 2 5 mol· L-1H2 SO4 为流动相 ,柱温为 6 5℃ ,流速为 0 .5 m L·min-1,以示差检测器检测 ,外标法峰面积定量。本法测定线性范围为 1μg~ 4 0μg,方法平均回收率为96 .1% ,RSD为 0 .83% (n=5 ) ,体外溶出度测定结果为 96 %~ 99%。本法测定海力特胶囊含量和溶出度 ,具有方法简便、快捷 ,重复性好的特点 ,可作为制剂质量控制方法。 展开更多
关键词 海力特胶囊 高效液相色谱法 溶出度 海洋生物 海洋药物
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干扰素-α_1b联合海力特治疗慢性乙型肝炎32例
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作者 潘兆随 李曾欣 +1 位作者 杨振芳 张庆 《中国临床药理学与治疗学》 CAS CSCD 2001年第4期370-370,共1页
关键词 干扰素-Α1B 海力特 慢性乙型肝炎 治疗方法
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Dynamic Characteristics of Irregular Ice Floes Based on Polyhedral Discrete Element Method
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作者 LI Ji WANG Si-qiang +1 位作者 LIU Lu JI Shun-ying 《船舶力学》 EI CSCD 北大核心 2024年第12期1849-1863,共15页
In polar regions, floating ice exhibits distinct characteristics across a range of spatial scales. It is well recognized that the irregular geometry of these ice formations markedly influences their dynamic behavior. ... In polar regions, floating ice exhibits distinct characteristics across a range of spatial scales. It is well recognized that the irregular geometry of these ice formations markedly influences their dynamic behavior. This study introduces a polyhedral Discrete Element Method (DEM) tailored for polar ice, incorporating the Gilbert-Johnson-Keerthi (GJK) and Expanding Polytope Algorithm (EPA) for contact detection. This approach facilitates the simulation of the drift and collision processes of floating ice, effectively capturing its freezing and fragmentation. Subsequently, the stability and reli ability of this model are validated by uniaxial compression on level ice fields, focusing specifically on the influence of compression strength on deformation resistance. Additionally, clusters of ice floes nav igating through narrow channels are simulated. These studies have qualitatively assessed the effects of Floe Size Distribution (FSD), initial concentration, and circularity on their flow dynamics. The higher power-law exponent values in the FSD, increased circularity, and decreased concentration are each as sociated with accelerated flow in ice floe fields. The simulation results distinctly demonstrate the con siderable impact of sea ice geometry on the movement of clusters, offering valuable insights into the complexities of polar ice dynamics. 展开更多
关键词 discrete element method GJK-EPA algorithm sea ice dynamics floe geometry
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