Valveless piezoelectric pump is widely used in the medical,however,there is a general and difficult problem to be solved:Low vortex and large flow rate are not compatible,resulting in the blood prone to thrombosis dur...Valveless piezoelectric pump is widely used in the medical,however,there is a general and difficult problem to be solved:Low vortex and large flow rate are not compatible,resulting in the blood prone to thrombosis during blood delivery.In this paper,a new valveless piezoelectric(PZT)pump with streamlined flow tubes(streamlined pump)is proposed.The design method and the working principle of the pump are analyzed.The velocity streamlines are simulated,and the results demonstrate that there are no obvious vortexes in the flow tube of the streamlined pump.Five prototype pumps(two cone pumps and three streamlined pumps)are designed and fabricated to perform flow rate and flow resistance experiments.The experimental results illustrate that the maximum flow rate of the streamlined pump is 142 mL/min,which is 179%higher than that of the cone piezoelectric pump,demonstrating that the streamlined pump has a large flow rate performance.This research provides an inspiration for future research on simple structure,low vortex and large flow rate volume-type pumps,and also provides a useful solution for thrombosis preventing.展开更多
Reduced blood flow is the principle pathophysiologic event in acute ischernic stroke.Hence,flow augmentation is the most important goal in stroke management.Improvement of cerebral blood flow can be accomplished by pr...Reduced blood flow is the principle pathophysiologic event in acute ischernic stroke.Hence,flow augmentation is the most important goal in stroke management.Improvement of cerebral blood flow can be accomplished by proximal arterial recanalization or by other systemic approaches.Diastolic counterpulsation is a non-invasive method to improve the perfusion of heart,kidneys and brain.This review summarizes the history,possible mechanism and the role of external counterpulsation in ischemic stroke.展开更多
Toad red blood cells were used to measure regional bone blood flow in the canine mandibular ramus. The blood cells were labelled with sodium pertechnetate and fixed in 1 0%formalin; they were 22 × 15 μm in size ...Toad red blood cells were used to measure regional bone blood flow in the canine mandibular ramus. The blood cells were labelled with sodium pertechnetate and fixed in 1 0%formalin; they were 22 × 15 μm in size and had a specific gravity close to that of dog red blood cells. These cells had no discernible effect on systemic hemodynamics after injection, did not agglutinate, were well mixed and evenly distributed throughout the body, and were completely extracted in one circulation through the mandible. The mandibular ramus was divided into six regions. and the blood flow rates in each were found to be similar to those reported in previous studies with radiolabelled carbonized, microspheres. Furthermore, the blood flow distribution pattern of the mandibular ramus determined in this study was identical to that of our previous study using the bone-seeking radionuclide method. We suggest that radiolabelled toad red blood cells are an ideal marker for measuring regional blood flow in the canine mandible.展开更多
基金supported by the National Natural Science Foundation of China (No. 51375227)the Introduction of Talent Research Start-up Fund of Nanjing Institute of Technology(No. YKJ201960).
文摘Valveless piezoelectric pump is widely used in the medical,however,there is a general and difficult problem to be solved:Low vortex and large flow rate are not compatible,resulting in the blood prone to thrombosis during blood delivery.In this paper,a new valveless piezoelectric(PZT)pump with streamlined flow tubes(streamlined pump)is proposed.The design method and the working principle of the pump are analyzed.The velocity streamlines are simulated,and the results demonstrate that there are no obvious vortexes in the flow tube of the streamlined pump.Five prototype pumps(two cone pumps and three streamlined pumps)are designed and fabricated to perform flow rate and flow resistance experiments.The experimental results illustrate that the maximum flow rate of the streamlined pump is 142 mL/min,which is 179%higher than that of the cone piezoelectric pump,demonstrating that the streamlined pump has a large flow rate performance.This research provides an inspiration for future research on simple structure,low vortex and large flow rate volume-type pumps,and also provides a useful solution for thrombosis preventing.
文摘Reduced blood flow is the principle pathophysiologic event in acute ischernic stroke.Hence,flow augmentation is the most important goal in stroke management.Improvement of cerebral blood flow can be accomplished by proximal arterial recanalization or by other systemic approaches.Diastolic counterpulsation is a non-invasive method to improve the perfusion of heart,kidneys and brain.This review summarizes the history,possible mechanism and the role of external counterpulsation in ischemic stroke.
文摘Toad red blood cells were used to measure regional bone blood flow in the canine mandibular ramus. The blood cells were labelled with sodium pertechnetate and fixed in 1 0%formalin; they were 22 × 15 μm in size and had a specific gravity close to that of dog red blood cells. These cells had no discernible effect on systemic hemodynamics after injection, did not agglutinate, were well mixed and evenly distributed throughout the body, and were completely extracted in one circulation through the mandible. The mandibular ramus was divided into six regions. and the blood flow rates in each were found to be similar to those reported in previous studies with radiolabelled carbonized, microspheres. Furthermore, the blood flow distribution pattern of the mandibular ramus determined in this study was identical to that of our previous study using the bone-seeking radionuclide method. We suggest that radiolabelled toad red blood cells are an ideal marker for measuring regional blood flow in the canine mandible.
