Ti-based biomaterial has been widely used as dental and bone implant material although its bioacti-vity still needs improvement especially for dental implant.The bone morphogenetic proteins(BMPs) bound to Ti-based mat...Ti-based biomaterial has been widely used as dental and bone implant material although its bioacti-vity still needs improvement especially for dental implant.The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells,which benefits the response to the protein-material surface,and finally leads to new bone formation.Several methods including physically mixing,coating,plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials.The latest research papers are focused on the structure and function of BMPs,and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.展开更多
文摘Ti-based biomaterial has been widely used as dental and bone implant material although its bioacti-vity still needs improvement especially for dental implant.The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells,which benefits the response to the protein-material surface,and finally leads to new bone formation.Several methods including physically mixing,coating,plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials.The latest research papers are focused on the structure and function of BMPs,and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.
