2α,3α-epoxy-16β-(1-pyrrolidinyl)-androstan-17β-ol,a main intermediate of Rocuronium bromide,was synthesized from epiandrosterone by elimination,bromination,epoxidation,N-alkylation and reduction with assisted micr...2α,3α-epoxy-16β-(1-pyrrolidinyl)-androstan-17β-ol,a main intermediate of Rocuronium bromide,was synthesized from epiandrosterone by elimination,bromination,epoxidation,N-alkylation and reduction with assisted microwave irradiation.The new approach could significantly shorten the reaction time,improve the reaction selectivity and the yield.The structures were confirmed by 1H-NMR and MS.展开更多
文摘2α,3α-epoxy-16β-(1-pyrrolidinyl)-androstan-17β-ol,a main intermediate of Rocuronium bromide,was synthesized from epiandrosterone by elimination,bromination,epoxidation,N-alkylation and reduction with assisted microwave irradiation.The new approach could significantly shorten the reaction time,improve the reaction selectivity and the yield.The structures were confirmed by 1H-NMR and MS.
