Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect ...Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.展开更多
文摘Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H 2O 2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H 2O 2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.
