Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Meth...Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and展开更多
文摘Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and
