The problem of discrete-time model identification of industrial processes with time delay was investigated.An iterative and separable method is proposed to solve this problem,that is,the rational transfer function mod...The problem of discrete-time model identification of industrial processes with time delay was investigated.An iterative and separable method is proposed to solve this problem,that is,the rational transfer function model parameters and time delay are alternately fixed to estimate each other.The instrumental variable technique is applied to guarantee consistent estimation against measurement noise.A noteworthy merit of the proposed method is that it can handle fractional time delay estimation,compared to existing methods commonly assuming that the time delay is an integer multiple of the sampling interval.The identifiability analysis for time delay is addressed and correspondingly,some guidelines are provided for practical implementation of the proposed method.Numerical and experimental examples are presented to illustrate the effectiveness of the proposed method.展开更多
Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacoki...Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacokinetics parameters,nonlinear mixed effects model(NONMEM),has the abuses of tedious work and plenty of man-made jamming factors.The Elman feedback neural network was built.The relationships between the patients’plasma concentration of remifentanil and time,patient’age,gender,lean body mass,height,body surface area,sampling time,total dose,and injection rate through network training were obtained to predict the plasma concentration of remifentanil,and after that,it was compared with the results of NONMEM algorithm.In conclusion,the average error of Elman network is 6.34%,while that of NONMEM is 18.99%.The absolute average error of Elman network is 27.07%,while that of NONMEM is 38.09%.The experimental results indicate that Elman neural network could predict the plasma concentration of remifentanil rapidly and stably,with high accuracy and low error.For the characteristics of simple principle and fast computing speed,this method is suitable to data analysis of short-acting anesthesia drug population pharmacokinetic and pharmacodynamics.展开更多
Combining mathematical morphology (MM),nonparametric and nonlinear model,a novel approach for predicting slope displacement was developed to improve the prediction accuracy.A parallel-composed morphological filter wit...Combining mathematical morphology (MM),nonparametric and nonlinear model,a novel approach for predicting slope displacement was developed to improve the prediction accuracy.A parallel-composed morphological filter with multiple structure elements was designed to process measured displacement time series with adaptive multi-scale decoupling.Whereafter,functional-coefficient auto regressive (FAR) models were established for the random subsequences.Meanwhile,the trend subsequence was processed by least squares support vector machine (LSSVM) algorithm.Finally,extrapolation results obtained were superposed to get the ultimate prediction result.Case study and comparative analysis demonstrate that the presented method can optimize training samples and show a good nonlinear predicting performance with low risk of choosing wrong algorithms.Mean absolute percentage error (MAPE) and root mean square error (RMSE) of the MM-FAR&LSSVM predicting results are as low as 1.670% and 0.172 mm,respectively,which means that the prediction accuracy are improved significantly.展开更多
文摘The problem of discrete-time model identification of industrial processes with time delay was investigated.An iterative and separable method is proposed to solve this problem,that is,the rational transfer function model parameters and time delay are alternately fixed to estimate each other.The instrumental variable technique is applied to guarantee consistent estimation against measurement noise.A noteworthy merit of the proposed method is that it can handle fractional time delay estimation,compared to existing methods commonly assuming that the time delay is an integer multiple of the sampling interval.The identifiability analysis for time delay is addressed and correspondingly,some guidelines are provided for practical implementation of the proposed method.Numerical and experimental examples are presented to illustrate the effectiveness of the proposed method.
基金Project(31200748)supported by the National Natural Science Foundation of China
文摘Due to the nature of ultra-short-acting opioid remifentanil of high time-varying,complex compartment model and low-accuracy of plasma concentration prediction,the traditional estimation method of population pharmacokinetics parameters,nonlinear mixed effects model(NONMEM),has the abuses of tedious work and plenty of man-made jamming factors.The Elman feedback neural network was built.The relationships between the patients’plasma concentration of remifentanil and time,patient’age,gender,lean body mass,height,body surface area,sampling time,total dose,and injection rate through network training were obtained to predict the plasma concentration of remifentanil,and after that,it was compared with the results of NONMEM algorithm.In conclusion,the average error of Elman network is 6.34%,while that of NONMEM is 18.99%.The absolute average error of Elman network is 27.07%,while that of NONMEM is 38.09%.The experimental results indicate that Elman neural network could predict the plasma concentration of remifentanil rapidly and stably,with high accuracy and low error.For the characteristics of simple principle and fast computing speed,this method is suitable to data analysis of short-acting anesthesia drug population pharmacokinetic and pharmacodynamics.
基金Project(20090162120084)supported by Research Fund for the Doctoral Program of Higher Education of ChinaProject(08JJ4014)supported by the Natural Science Foundation of Hunan Province,China
文摘Combining mathematical morphology (MM),nonparametric and nonlinear model,a novel approach for predicting slope displacement was developed to improve the prediction accuracy.A parallel-composed morphological filter with multiple structure elements was designed to process measured displacement time series with adaptive multi-scale decoupling.Whereafter,functional-coefficient auto regressive (FAR) models were established for the random subsequences.Meanwhile,the trend subsequence was processed by least squares support vector machine (LSSVM) algorithm.Finally,extrapolation results obtained were superposed to get the ultimate prediction result.Case study and comparative analysis demonstrate that the presented method can optimize training samples and show a good nonlinear predicting performance with low risk of choosing wrong algorithms.Mean absolute percentage error (MAPE) and root mean square error (RMSE) of the MM-FAR&LSSVM predicting results are as low as 1.670% and 0.172 mm,respectively,which means that the prediction accuracy are improved significantly.
