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八肽胆囊收缩素对小鼠神经元蛋白质磷酸化的影响
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作者 王丽 何涛 +4 位作者 李娟 刘晓燕 段承刚 谢华福 宋杰 《郑州大学学报(医学版)》 CAS 北大核心 2008年第2期300-303,共4页
目的:从蛋白质可逆磷酸化修饰的角度,对小鼠神经元在八肽胆囊收缩素(CCK8)刺激下的信号转导通路进行初步研究。方法:将培养的小鼠神经元分为对照组(加入无磷培养基)、实验组(加入CCK8)、拮抗剂组(分别加入CCKA受体拮抗剂L-364718和(或)C... 目的:从蛋白质可逆磷酸化修饰的角度,对小鼠神经元在八肽胆囊收缩素(CCK8)刺激下的信号转导通路进行初步研究。方法:将培养的小鼠神经元分为对照组(加入无磷培养基)、实验组(加入CCK8)、拮抗剂组(分别加入CCKA受体拮抗剂L-364718和(或)CCKB受体拮抗剂L-365260)。采用双向电泳法观察CCK8和受体拮抗剂作用下蛋白质磷酸化水平的改变。结果:CCK8作用不同时间后,神经元蛋白质磷酸化状态发生明显改变,涉及的信号转导相关磷酸化蛋白质包括多种蛋白激酶、胞内信号分子、激素受体、转录因子等;动力学分析结果显示,主要的信号转导相关蛋白的磷酸化时间动力学曲线多数呈峰型;应用CCK受体拮抗剂作用后的结果表明,在皮质神经元中同时存在CCK的2种类型受体,其中B型受体介导的信号转导途径更复杂。结论:CCKA型、B型受体均可介导CCK8在神经元的信号转导,其中B型受体介导的信号途径可能包括肌醇磷脂信使系统、cAMP-PKA途径、MAPK途径和JNK途径等。 展开更多
关键词 胆囊收缩素 神经元 信号转导 时间动力学曲线 受体 拮抗剂 小鼠
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MPC-based path tracking with PID speed control for high-speed autonomous vehicles considering time-optimal travel 被引量:29
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作者 CHEN Shu-ping XIONG Guang-ming +1 位作者 CHEN Hui-yan NEGRUT Dan 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第12期3702-3720,共19页
In order to track the desired path as fast as possible,a novel autonomous vehicle path tracking based on model predictive control(MPC)and PID speed control was proposed for high-speed automated vehicles considering th... In order to track the desired path as fast as possible,a novel autonomous vehicle path tracking based on model predictive control(MPC)and PID speed control was proposed for high-speed automated vehicles considering the constraints of vehicle physical limits,in which a forward-backward integration scheme was introduced to generate a time-optimal speed profile subject to the tire-road friction limit.Moreover,this scheme was further extended along one moving prediction window.In the MPC controller,the prediction model was an 8-degree-of-freedom(DOF)vehicle model,while the plant was a 14-DOF vehicle model.For lateral control,a sequence of optimal wheel steering angles was generated from the MPC controller;for longitudinal control,the total wheel torque was generated from the PID speed controller embedded in the MPC framework.The proposed controller was implemented in MATLAB considering arbitrary curves of continuously varying curvature as the reference trajectory.The simulation test results show that the tracking errors are small for vehicle lateral and longitudinal positions and the tracking performances for trajectory and speed are good using the proposed controller.Additionally,the case of extended implementation in one moving prediction window requires shorter travel time than the case implemented along the entire path. 展开更多
关键词 model predictive control path tracking minimum-time speed profile vehicle dynamics arbitrary path
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