目的探讨归芪白术方辅助化疗在中晚期胃癌中的应用效果。方法以随机数字表法将2021年8月—2022年12月在该院接受治疗的127例中晚期胃癌分为Ⅰ组(63例)与Ⅱ组(64例)。Ⅰ组采取常规化疗治疗,Ⅱ组在Ⅰ组基础上使用归芪白术方辅助治疗,两组...目的探讨归芪白术方辅助化疗在中晚期胃癌中的应用效果。方法以随机数字表法将2021年8月—2022年12月在该院接受治疗的127例中晚期胃癌分为Ⅰ组(63例)与Ⅱ组(64例)。Ⅰ组采取常规化疗治疗,Ⅱ组在Ⅰ组基础上使用归芪白术方辅助治疗,两组均治疗1个化疗周期并随访6个月。比较两组治疗后6个月临床疗效、治疗前及治疗后6个月生活质量评分、功能状态评分、中医证候积分、免疫功能、肿瘤标志物水平、治疗期间不良反应发生率。结果与Ⅰ组比较,Ⅱ组治疗后6个月总有效率更高;与治疗前比较,治疗后6个月两组欧洲癌症研究与治疗组织生命质量测定量表(European organization for research and treatment of cancer,EORTC QLQ-C30)、卡氏功能状态评分标准(Karnofsky functional status,KPS)评分、血清CD_(3)^(+)、CD_(4)^(+)、自然杀伤细胞(natural killer cells,NK)水平均上升,Ⅱ组高于Ⅰ组;与治疗前比较,治疗后6个月两组中医证候积分、血清CD_(8)^(+)、细胞角蛋白19片段21-1(cytokeratin 19 fragment 21-1,CYFRA21-1)、癌抗原19-9(cancer antigen 19-9,CA19-9)、癌抗原125(cancer antigen 125,CA125)、组织多肽特异抗原(tissue polypeptide specific antigen,TPS)水平均降低,Ⅱ组低于Ⅰ组;与Ⅰ组比较,治疗期间Ⅱ组各项不良反应发生率均更低,差异具备统计学意义(P<0.05)。结论归芪白术方辅助化疗在中晚期胃癌治疗中可有效提高临床疗效,增强免疫功能,降低肿瘤标志物表达水平,缓解临床症状,提升患者生活质量及功能状态,降低不良反应发生风险。展开更多
We consider the multiplicity of solutions to a p(x)-Laplacian problem involving supercritical Sobolev growth via Ricceri’s principle.By means of truncation combined with De Giorgi iteration,we can extend the results ...We consider the multiplicity of solutions to a p(x)-Laplacian problem involving supercritical Sobolev growth via Ricceri’s principle.By means of truncation combined with De Giorgi iteration,we can extend the results of subcritical and critical growth to supercritical growth and obtain at least three solutions to the p(x)-Laplacian problem.展开更多
In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective o...In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective of thisreview is to conduct a comprehensive study on the experiments and failure mechanisms of strain and fault-slip rockburst.Firstly,the article analyzes the evolving trends in experimental research on rockburst in the past decade,highlightingmechanical properties and failure modes as the primary research focuses in understanding rockburst mechanisms.Subsequently,it provides an overview of the experimental techniques and methods employed for studying both types ofrockburst.Then,with a focus on the mechanical properties and failure modes,the article conducts an extensive analysisof the failure mechanisms associated with strain and fault-slip rockburst.By analyzing experimental data and observingthe failure characteristics of samples,it discusses the variations and common features exhibited by these two types ofrockburst under various test conditions.This analysis is of paramount importance in revealing the causes of rockburstformation and development,as well as in predicting rockburst trends and assessing associated risks.Lastly,thelimitations of current rockburst experiments and future research directions are discussed,followed by a comprehensivesummary of the entire article.展开更多
文摘目的探讨归芪白术方辅助化疗在中晚期胃癌中的应用效果。方法以随机数字表法将2021年8月—2022年12月在该院接受治疗的127例中晚期胃癌分为Ⅰ组(63例)与Ⅱ组(64例)。Ⅰ组采取常规化疗治疗,Ⅱ组在Ⅰ组基础上使用归芪白术方辅助治疗,两组均治疗1个化疗周期并随访6个月。比较两组治疗后6个月临床疗效、治疗前及治疗后6个月生活质量评分、功能状态评分、中医证候积分、免疫功能、肿瘤标志物水平、治疗期间不良反应发生率。结果与Ⅰ组比较,Ⅱ组治疗后6个月总有效率更高;与治疗前比较,治疗后6个月两组欧洲癌症研究与治疗组织生命质量测定量表(European organization for research and treatment of cancer,EORTC QLQ-C30)、卡氏功能状态评分标准(Karnofsky functional status,KPS)评分、血清CD_(3)^(+)、CD_(4)^(+)、自然杀伤细胞(natural killer cells,NK)水平均上升,Ⅱ组高于Ⅰ组;与治疗前比较,治疗后6个月两组中医证候积分、血清CD_(8)^(+)、细胞角蛋白19片段21-1(cytokeratin 19 fragment 21-1,CYFRA21-1)、癌抗原19-9(cancer antigen 19-9,CA19-9)、癌抗原125(cancer antigen 125,CA125)、组织多肽特异抗原(tissue polypeptide specific antigen,TPS)水平均降低,Ⅱ组低于Ⅰ组;与Ⅰ组比较,治疗期间Ⅱ组各项不良反应发生率均更低,差异具备统计学意义(P<0.05)。结论归芪白术方辅助化疗在中晚期胃癌治疗中可有效提高临床疗效,增强免疫功能,降低肿瘤标志物表达水平,缓解临床症状,提升患者生活质量及功能状态,降低不良反应发生风险。
基金supported by the Fundamental Research Funds for the Central Universities(2024KYJD2006).
文摘We consider the multiplicity of solutions to a p(x)-Laplacian problem involving supercritical Sobolev growth via Ricceri’s principle.By means of truncation combined with De Giorgi iteration,we can extend the results of subcritical and critical growth to supercritical growth and obtain at least three solutions to the p(x)-Laplacian problem.
基金Project(52227901)supported by the National Natural Science Foundation of ChinaProject(2308085ME153)supported by the Anhui Provincial Natural Science Foundation,China+2 种基金Project(2022AH030088)supported by the University Natural Science Foundation of Anhui Province,ChinaProject(EC2022011)supported by the Foundation of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining,ChinaProject(GXXT-2022-020)supported by the University Synergy Innovation Program of Anhui Province,China。
文摘In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective of thisreview is to conduct a comprehensive study on the experiments and failure mechanisms of strain and fault-slip rockburst.Firstly,the article analyzes the evolving trends in experimental research on rockburst in the past decade,highlightingmechanical properties and failure modes as the primary research focuses in understanding rockburst mechanisms.Subsequently,it provides an overview of the experimental techniques and methods employed for studying both types ofrockburst.Then,with a focus on the mechanical properties and failure modes,the article conducts an extensive analysisof the failure mechanisms associated with strain and fault-slip rockburst.By analyzing experimental data and observingthe failure characteristics of samples,it discusses the variations and common features exhibited by these two types ofrockburst under various test conditions.This analysis is of paramount importance in revealing the causes of rockburstformation and development,as well as in predicting rockburst trends and assessing associated risks.Lastly,thelimitations of current rockburst experiments and future research directions are discussed,followed by a comprehensivesummary of the entire article.
