In recent decades, the outcomes of coronary heart disease （CHD） have markedly improved, which can be partly attributed to the use of novel drugs （especially statins and antiplatelet drugs） and partly to the evolut...In recent decades, the outcomes of coronary heart disease （CHD） have markedly improved, which can be partly attributed to the use of novel drugs （especially statins and antiplatelet drugs） and partly to the evolution ofpercutaneous coronary intervention （PCI）. From percutaneous transluminal coronary angioplasty to bare-metal stent and then to drug-eluting stent, every step of PCI is attractive to interventional cardiologist, great progress has been made for patients with CHD. In the past few years, some successor devices for treating CHD have cmerged. Undoubtedly, drug-coated balloon （DCB）, which was recommended by 2014 ESC Guidelines on myocardial revascularization, is a ＂shining star＂ among them. DCB involves a semi-compliant angioplasty balloon coated with an anti-proliferative agent that can exert antirestenotic efficacy by permeating into the vessel wall during balloon contact. This review discusses the conception and merits, preclinical data, emerging clinical indications, and results from clinical trials of this novel interventional technology. Although DCB has shown authentic efficacy in the treatment ofin-stent restenosis, its use in de novo coronary lesions is still in dispute. Hence, concerns and the future direction of DCB are also covered in this paper.展开更多
Based on break characteristics of roofs in fully mechanized top-coal mining of thick shallow coal seams, a fracture mechanics model was built, and the criterion of crack propagation in the main roof was derived using ...Based on break characteristics of roofs in fully mechanized top-coal mining of thick shallow coal seams, a fracture mechanics model was built, and the criterion of crack propagation in the main roof was derived using the fracture mechanics theory. The relationships between the fracture length of the roof and the working resistance of the supports were discovered, and the correlations between the load on the overlying strata and the ratio of the crack's length to the thickness of the roof were obtained. Using a working face of Jindi Coal Mine, Xing county Shanxi province as an example, the relationships between the fracture length of the roof and the working resistance of the supports were analysed in detail. The results give a design basis in hydraulic top coal caving supports, which could provide useful references in the practical application. On-site experiment proves that the periodic weighting step interval of the caving face is 15–16 m, which is basically consistent with the theoretical analysis results, and indicates that the mechanized caving hydraulic support is capable of meeting the support requirements in the mining of a super-thick but shallowly buried coal seam.展开更多
文摘In recent decades, the outcomes of coronary heart disease （CHD） have markedly improved, which can be partly attributed to the use of novel drugs （especially statins and antiplatelet drugs） and partly to the evolution ofpercutaneous coronary intervention （PCI）. From percutaneous transluminal coronary angioplasty to bare-metal stent and then to drug-eluting stent, every step of PCI is attractive to interventional cardiologist, great progress has been made for patients with CHD. In the past few years, some successor devices for treating CHD have cmerged. Undoubtedly, drug-coated balloon （DCB）, which was recommended by 2014 ESC Guidelines on myocardial revascularization, is a ＂shining star＂ among them. DCB involves a semi-compliant angioplasty balloon coated with an anti-proliferative agent that can exert antirestenotic efficacy by permeating into the vessel wall during balloon contact. This review discusses the conception and merits, preclinical data, emerging clinical indications, and results from clinical trials of this novel interventional technology. Although DCB has shown authentic efficacy in the treatment ofin-stent restenosis, its use in de novo coronary lesions is still in dispute. Hence, concerns and the future direction of DCB are also covered in this paper.
文摘Based on break characteristics of roofs in fully mechanized top-coal mining of thick shallow coal seams, a fracture mechanics model was built, and the criterion of crack propagation in the main roof was derived using the fracture mechanics theory. The relationships between the fracture length of the roof and the working resistance of the supports were discovered, and the correlations between the load on the overlying strata and the ratio of the crack's length to the thickness of the roof were obtained. Using a working face of Jindi Coal Mine, Xing county Shanxi province as an example, the relationships between the fracture length of the roof and the working resistance of the supports were analysed in detail. The results give a design basis in hydraulic top coal caving supports, which could provide useful references in the practical application. On-site experiment proves that the periodic weighting step interval of the caving face is 15–16 m, which is basically consistent with the theoretical analysis results, and indicates that the mechanized caving hydraulic support is capable of meeting the support requirements in the mining of a super-thick but shallowly buried coal seam.
