目的比较原发性卵巢功能不全(primary ovarian insufficiency,POI)病人、绝经期妇女及正常体检女性的性激素、糖脂代谢及其他生物化学指标之间的差异,以期提高对POI病人健康状况的关注程度。方法纳入108例POI病人、114名绝经期女性、63...目的比较原发性卵巢功能不全(primary ovarian insufficiency,POI)病人、绝经期妇女及正常体检女性的性激素、糖脂代谢及其他生物化学指标之间的差异,以期提高对POI病人健康状况的关注程度。方法纳入108例POI病人、114名绝经期女性、63例正常体检女性,分别测量其性激素、糖脂代谢、其他生物化学指标(相关检测试剂盒的批间误差、批内误差控制在3%~5%)。结果 3组之间体质量指数(body mass index,BMI)差异无统计学意义(P>0.05),卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)两两比较差异均有统计学意义(P<0.05)。总胆固醇(total cholesterol,TC)、空腹胰岛素[fasting insulin,FINS]、胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)POI组与绝经组的测量值均明显大于对照组(P<0.05)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)和睾酮(testosterone,T)浓度明显低于对照组(P<0.05)。结论本研究中POI病人的TC、FINS、HOMA-IR、HDL-C已经达到绝经期女性水平(P<0.05),长期发展可能影响病人的生活质量,临床医生应及早对POI病人进行干预与治疗。展开更多
下肢深静脉瓣膜功能不全引起的倒流性疾病占下肢静脉疾病的绝大多数，直到Kistner正式提出原发性下肢深静脉瓣膜功能不全（Primary deep venous insufficiency，PDVI）的概念后，国内外学者才对PDVI的发病机理和治疗进行了系统的探索与...下肢深静脉瓣膜功能不全引起的倒流性疾病占下肢静脉疾病的绝大多数，直到Kistner正式提出原发性下肢深静脉瓣膜功能不全（Primary deep venous insufficiency，PDVI）的概念后，国内外学者才对PDVI的发病机理和治疗进行了系统的探索与研究。本文就PDVI目前各种手术方式及其选择作一综述。展开更多
Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with C...Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.展开更多
文摘目的比较原发性卵巢功能不全(primary ovarian insufficiency,POI)病人、绝经期妇女及正常体检女性的性激素、糖脂代谢及其他生物化学指标之间的差异,以期提高对POI病人健康状况的关注程度。方法纳入108例POI病人、114名绝经期女性、63例正常体检女性,分别测量其性激素、糖脂代谢、其他生物化学指标(相关检测试剂盒的批间误差、批内误差控制在3%~5%)。结果 3组之间体质量指数(body mass index,BMI)差异无统计学意义(P>0.05),卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)两两比较差异均有统计学意义(P<0.05)。总胆固醇(total cholesterol,TC)、空腹胰岛素[fasting insulin,FINS]、胰岛素抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR)POI组与绝经组的测量值均明显大于对照组(P<0.05)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)和睾酮(testosterone,T)浓度明显低于对照组(P<0.05)。结论本研究中POI病人的TC、FINS、HOMA-IR、HDL-C已经达到绝经期女性水平(P<0.05),长期发展可能影响病人的生活质量,临床医生应及早对POI病人进行干预与治疗。
文摘下肢深静脉瓣膜功能不全引起的倒流性疾病占下肢静脉疾病的绝大多数，直到Kistner正式提出原发性下肢深静脉瓣膜功能不全（Primary deep venous insufficiency，PDVI）的概念后，国内外学者才对PDVI的发病机理和治疗进行了系统的探索与研究。本文就PDVI目前各种手术方式及其选择作一综述。
文摘Objective To observe the value of real-time shear wave elastography(SWE)combined with biochemical indicators for evaluating liver injury in patients with chronic kidney disease(CKD).Methods Totally 210 patients with CKD(CKD group)and 64 healthy subjects(control group)were retrospectively enrolled.Patients in CKD group were further divided into CKD1—5 subgroups according to CKD stages.SWE parameters of liver and kidney,including mean value,the maximum value and the median value of Young's modulus(EQI mean,EQI max and EQI med)were compared between CKD subgroups and control group.Spearman correlation analysis were performed to explore the correlations of liver and kidney SWE parameters with CKD stage,as well as of liver SWE parameters with biochemical indicators.Multivariate logistic regression analysis was used to screen independent predictors of liver injury in CKD patients.Receiver operating characteristic curves were drawn,the area under the curves(AUC)were calculated to evaluate the efficacy of the independent predictors alone and their combination for assessing liver injury in CKD patients.Results Significant differences of liver and kidney SWE parameters were found among CKD subgroups and control group(all P≤0.001).Pairwise comparison showed that liver SWE parameters in CKD5 subgroup and liver EQI max in CKD4 subgroup were all higher than those in control group(all P<0.003).Kidney SWE parameters in CKD3 subgroup were all higher than those in control group,while in CKD4 subgroup were all higher than those in control group and CKD1—3 subgroup(all P<0.003).Kidney EQI mean and EQI med in CKD5 subgroup were all higher than those in control group and CKD1—4 subgroup,while kidney EQI max in CKD5 subgroup were higher than those in control group and CKD1—3 subgroup(all P<0.003).Liver and kidney SWE parameters were lowly-moderately and positively correlated with CKD stages(r=0.364—0.665,all P<0.001).Liver SWE parameters of CKD were weakly and positively correlated with alkaline phosphatase(ALP)(r=0.229—0.248,all P<0.01).Theγ-glutamyl transferase,ALP and liver EQI max were all independent predictors of liver injury in CKD patients(all P<0.01),with AUC for evaluating liver injury in CKD patients alone of 0.645,0.756 and 0.741,respectively,lower than that of their combination(0.851,all P<0.01).Conclusion Real-time SWE combined with liver function indicators could reflect degree of liver injury in patients with different CKD stages.
