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冻干粉抗凝针剂三种皮下注射方法的安全评析 被引量:4
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作者 葛静萍 顾建平 +2 位作者 许秀芳 甘舒琴 李燕 《介入放射学杂志》 CSCD 北大核心 2020年第11期1159-1164,共6页
目的比较三种方法在冻干粉针剂皮下注射抗凝治疗中的安全性及可行性。方法纳入2018年3月至2019年12月注射用那屈肝素钙抗凝治疗的106例患者,BD注射器组(A组)34例;1 mL无菌注射器组(B组)36例;1 mL无菌注射器+无菌注射针组(C组)36例:1 mL... 目的比较三种方法在冻干粉针剂皮下注射抗凝治疗中的安全性及可行性。方法纳入2018年3月至2019年12月注射用那屈肝素钙抗凝治疗的106例患者,BD注射器组(A组)34例;1 mL无菌注射器组(B组)36例;1 mL无菌注射器+无菌注射针组(C组)36例:1 mL无菌注射器,先替换无菌注射针配制药液后,再更换配套针头皮下注射组,对药液残留量、针头受力后形态变化及并发症进行评价。结果加药后针头倾斜发生率及倾斜度:42.5%、35.18°±17.12°(A组),20.0%、18.00°±13.97°(B组),P<0.05;加药后针尖倒钩发生率及倒钩角度:57.5%、19.83°±17.14°(A组),35.0%、11.79°±8.55°(B组),P<0.05;注射部位皮下出血发生率及疼痛评分:17.23%、2.90±0.54(A组),11.90%、1.6±0.49(B组),4.96%、0.70±0.64(C组),P<0.05;冻干粉针剂西林瓶(以下简称西林瓶)瓶内药液残留量:(0.05±0.01)mL(A组),(0.11±0.06)mL(B组),0.01±0.00 mL(C组),P<0.05;针头腔内药液残留量:0.005±0.001 mL(A组),0.013±0.007 mL(B组),(0.03±0.003)mL(C组),P<0.05;抽液时间:(7.23±0.96)s(A组),(5.09±0.52)s(B组),(1.84±0.22)s(C组),P<0.05。结论冻干粉针剂皮下注射抗凝治疗中,使用1 mL注射器,先替换无菌注射针充分溶解冻干粉后静置5 s,瓶底抽取药液后,再更换配套针头皮下注射的方案,具有较高的药液利用率,在注射部位物理性损伤、并发症发生率、护理时效的安全性及可行性方面,明显优于BD注射器组及1mL注射器不换针头配制药液组。 展开更多
关键词 冻干粉针剂 皮下注射 抗凝治疗 安全评析
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A novel refined dynamic model of high-speed maglev train-bridge coupled system for random vibration and running safety assessment 被引量:1
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作者 MAO Jian-feng LI Dao-hang +3 位作者 YU Zhi-wu CAI Wen-feng GUO Wei ZHANG Guang-wen 《Journal of Central South University》 SCIE EI CAS CSCD 2024年第7期2532-2544,共13页
Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can b... Running safety assessment and tracking irregularity parametric sensitivity analysis of high-speed maglev train-bridge system are of great concern,especially need perfect refinement models in which all properties can be well characterized based on various stochastic excitations.A three-dimensional refined spatial random vibration analysis model of high-speed maglev train-bridge coupled system is established in this paper,in which multi-source uncertainty excitation can be considered simultaneously,and the probability density evolution method(PDEM)is adopted to reveal the system-specific uncertainty dynamic characteristic.The motion equation of the maglev vehicle model is composed of multi-rigid bodies with a total 210-degrees of freedom for each vehicle,and a refined electromagnetic force-air gap model is used to account for the interaction and coupling effect between the moving train and track beam bridges,which are directly established by using finite element method.The model is proven to be applicable by comparing with Monte Carlo simulation.By applying the proposed stochastic framework to the high maglev line,the random dynamic responses of maglev vehicles running on the bridges are studied for running safety and stability assessment.Moreover,the effects of track irregularity wavelength range under different amplitude and running speeds on the coupled system are investigated.The results show that the augmentation of train speed will move backward the sensitive wavelength interval,and track irregularity amplitude influences the response remarkably in the sensitive interval. 展开更多
关键词 maglev train-bridge interaction electromagnetic force-air gap model stochastic dynamic analysis running safety assessment probability density evolution method
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Three-dimensional analysis of slopes reinforced with piles 被引量:11
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作者 高玉峰 叶茂 张飞 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第6期2322-2327,共6页
Based on the upper bound of limit analysis, the plane-strain analysis of the slopes reinforced with a row of piles to the 3D case was extended. A 3D rotational failure mechanism was adopted to yield the upper bound of... Based on the upper bound of limit analysis, the plane-strain analysis of the slopes reinforced with a row of piles to the 3D case was extended. A 3D rotational failure mechanism was adopted to yield the upper bound of the factor of safety. Parametric studies were carried out to explore the end effects of the slope failures and the effects of the pile location and diameter on the safety of the reinforced slopes. The results demonstrate that the end effects nearly have no effects on the most suitable location of the installed piles but have significant influence on the safety of the slopes. For a slope constrained to a narrow width, the slope becomes more stable owing to the contribution of the end effects. When the slope is reinforced with a row of piles in small space between piles, the effects of group piles are significant for evaluating the safety of slopes. The presented method is more appropriate for assessing the stability of slopes reinforced with piles and can be also utilized in the design of plies stabilizing the unstable slopes. 展开更多
关键词 three-dimensional rotational failure mechanism stability of slopes limit analysis LANDSLIDES PILES
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