Objective:To investigate the association between the polymorphism of HLA-A,HLA-B genes and pre-eclampsia. Methods:HLA-A,HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in...Objective:To investigate the association between the polymorphism of HLA-A,HLA-B genes and pre-eclampsia. Methods:HLA-A,HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients,117 normal pregnant women and their neonates. Results:The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A,HLA-B alleles between pre-eclampsia group and control group (P_(c)>0.05). The frequencies of HLA-A11,HLA-A24,HLA-B13,HLA-B14,HLA-B15,HLA-B52 maternal/fetus genetic assoications were significantly diffe-rent between pre-eclampsia group and control group (P<0.05). Conclusion:Some HLA-A,HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.展开更多
文摘Objective:To investigate the association between the polymorphism of HLA-A,HLA-B genes and pre-eclampsia. Methods:HLA-A,HLA-B genotyping was performed by polymerase chain reaction sequence-specific primer (PCR-SSP) in 119 preeclampsia patients,117 normal pregnant women and their neonates. Results:The study showed that 16 HLA-A and 39 HLA-B alleles were obtained in pre-eclamptic patients and normal pregnant women. 15 HLA-A and 37 HLA-B alleles were obtained in their neonates. No significant difference was found in maternal or neonatal HLA-A,HLA-B alleles between pre-eclampsia group and control group (P_(c)>0.05). The frequencies of HLA-A11,HLA-A24,HLA-B13,HLA-B14,HLA-B15,HLA-B52 maternal/fetus genetic assoications were significantly diffe-rent between pre-eclampsia group and control group (P<0.05). Conclusion:Some HLA-A,HLA-B maternal/fetus special bindings may be associated with the susceptibility or protective of pre-eclampsia.
