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托珠单抗治疗儿童难治性多相性髓鞘少突胶质细胞糖蛋白抗体相关疾病2例病例报告并文献复习 被引量:1
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作者 常旭婷 李尚茹 +3 位作者 张捷 武元 姜玉武 吴晔 《中国循证儿科杂志》 CSCD 北大核心 2024年第2期98-103,共6页
背景国外病例报告及病例系列报告表明,托珠单抗(TCZ)可能对其他免疫抑制剂效果欠佳的难治性髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)有一定疗效,但多为成人研究,目前国内尚无儿童相关报道。目的 总结2例应用TCZ治疗的难治性MOGAD患... 背景国外病例报告及病例系列报告表明,托珠单抗(TCZ)可能对其他免疫抑制剂效果欠佳的难治性髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD)有一定疗效,但多为成人研究,目前国内尚无儿童相关报道。目的 总结2例应用TCZ治疗的难治性MOGAD患儿的临床特点及疗效,并对TCZ治疗MOGAD患者的疗效及安全性进行文献复习。设计病例报告并文献复习。方法 报告北京大学第一医院儿科收治的2例应用TCZ治疗难治性MOGAD患儿的病例资料,总结其临床特点及TCZ的疗效及安全性。以“MOGAD”、“抗髓鞘少突胶质细胞糖蛋白抗体”等和“TCZ”、“白细胞介素6受体拮抗剂”及相应英文检索词于PubMed、Embase、Web of Science、Cochrane、万方数据库、中国知网数据库、维普数据库检索中英文文献,检索时间为建库至2023年11月。主要结局指标TCZ的疗效及安全性。结果 2例MOGAD患儿分别于6岁6月龄和3岁7月龄起病,应用TCZ时的病程分别为9年3个月和6年6个月,此前分别出现11次和5次急性脱髓鞘事件发作,1例规律应用TCZ 14个月期间未出现复发,停用后复发,再次间断应用10个月期间复发1次;1例规律应用2年4个月未出现复发。2例治疗期间均未出现严重不良反应。文献复习纳入9项研究(含本文)共27例MOGAD患者,4例(14.8%)出现复发,27例治疗后年复发率均明显下降。应用TCZ治疗过程中最常见的不良反应为感染及高脂血症,无因严重不良反应而停止治疗的患者。Meta分析共纳入5项研究(含本文)23例患者,TCZ治疗MOGAD的无复发率为87%(95%CI:72%~100%)。结论 TCZ对其他传统免疫抑制剂治疗效果欠佳的难治性多相性MOGAD患儿有效且耐受性好,但仍需大样本的前瞻性研究进一步证实。 展开更多
关键词 MOG抗体相关疾病 多相性 儿童 托珠单抗
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二维相关荧光光谱探究土壤富里酸亚组分的质子键合多相性 被引量:5
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作者 宋凡浩 栗婷婷 +4 位作者 张进 刘沙沙 冯伟莹 何佳 白英臣 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2019年第10期3071-3077,共7页
利用同步荧光光谱(SFS)结合二维相关光谱(2D COS)和修正Stern-Volmer模型探究了森林土壤富里酸(FA)亚组分的质子键合多相性。利用XAD-8吸附树脂结合Na 4P 2O 7缓冲溶液逐步洗脱方法成功将土壤FA分级为异质性低的FA亚组分(FA 3-FA 13)。F... 利用同步荧光光谱(SFS)结合二维相关光谱(2D COS)和修正Stern-Volmer模型探究了森林土壤富里酸(FA)亚组分的质子键合多相性。利用XAD-8吸附树脂结合Na 4P 2O 7缓冲溶液逐步洗脱方法成功将土壤FA分级为异质性低的FA亚组分(FA 3-FA 13)。FA 3-FA 13含有类蛋白(类酪氨酸和类色氨酸)、类富里酸和类腐殖酸组分,且FA 7-FA 13比FA 3和FA 5含有更多含量的类蛋白组分。FA 3-FA 13中不同荧光组分的光谱峰强受溶液碱性pH值变化的影响较为明显。FA 3-FA 13的2D COS同步和异步相关谱图中自峰和交叉峰的复杂分布与荧光组分的质子键合多相性有关。FA 5-FA 13中类蛋白、类富里酸和类腐殖酸组分因pH值变量扰动而产生的光谱变化方向相同。在碱性pH值条件下,修正Stern-Volmer模型定量拟合FA 3-FA 13中荧光组分的解离常数(p K a值),其中类酪氨酸、类色氨酸、类富里酸和类腐殖酸的p K a值范围分别为6.11,8.93~10.12,9.32~10.65和9.70~10.63(R>0.854)。FA 3中类酪氨酸组分的低p K a值(6.11)表明类酪氨酸组分含有更多含量的芳香族结构和相邻酚基官能团。FA 3-FA 13中类色氨酸、类富里酸和类腐殖酸组分的相似p K a值(8.93~10.65)与羟基苯和氨基酸的p K a值(8.0~12.02)相近,表明类色氨酸、类富里酸和类腐殖酸组分具有相似的质子亲和力,且酚基官能团和氨基酸组分在其质子键合过程中起主要作用。FA 3-FA 13中特定波长处荧光组分的波长连续变化顺序与其p K a值递增趋势相一致,且质子结合位点的多相性特征同时存在于FA亚组分的不同荧光组分间和相同荧光组分内。FA 3中特定波长处类酪氨酸和类色氨酸组分的p K a值(6.11~9.16)小于类腐殖酸组分(9.70~9.97),且荧光组分的递增趋势与波长连续变化的顺序(250 nm→275 nm→425~490 nm)相一致。FA 5-FA 13中特定波长处类色氨酸组分、类富里酸和类腐殖酸组分的p K a值递增趋势与波长连续变化的顺序表现出相一致的规律:275 nm(8.93~9.70)→375~495 nm(9.88~10.16)→350 nm(10.65)(FA 5和FA 7),275 nm(10.11)→290~400 nm(10.35)(FA 9)和265~345 nm(9.32~9.80)→360~450 nm(10.06~10.13)(FA 13)。同时,FA 13中同一类富里酸组分的波长和p K a值存在325 nm(9.32)→375~425 nm(10.06~10.13)的连续变化顺序。SFS-2D COS结合修正Stern-Volmer模型具有降低光谱重叠率和捕获光谱波长连续变化的优势,为深入研究有机质和污染物间复杂相互作用提供支撑。 展开更多
关键词 富里酸亚组分 质子键合多相性 荧光组分 解离常数
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哈萨克斯坦柯切塔夫地块和中国大别山含金刚石变质杂岩的多相性(英文)
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《地学前缘》 EI CAS CSCD 1998年第3期39-49,共11页
中国中部大别杂岩和哈萨克斯坦柯切塔夫杂岩是世界著名的含金刚石变质杂岩,二者都位于地台边缘。笔者进行的矿物学岩石学研究揭示了这些杂岩中含金刚石变质岩的最主要性质———多相性。金刚石及其特征的共生矿物(钾质单斜辉石、柯石... 中国中部大别杂岩和哈萨克斯坦柯切塔夫杂岩是世界著名的含金刚石变质杂岩,二者都位于地台边缘。笔者进行的矿物学岩石学研究揭示了这些杂岩中含金刚石变质岩的最主要性质———多相性。金刚石及其特征的共生矿物(钾质单斜辉石、柯石英、石榴石、锆石等)的地幔性质指示含金刚石变质岩在成因上与约150~200km的岩浆房有关,这与金伯利岩筒的含金刚石岩浆岩的岩浆房相同。矿物相图反映了含金刚石岩浆作用中心的氢水特点,这可以解释金伯利岩金刚石中的含水矿物包裹体和大别变质杂岩中榴辉岩、石榴单辉岩的石榴石中含水矿物包裹体的存在。地内期高压矿化的石榴单辉岩和榴辉岩岩浆侵入到地幔上层和地壳中,这一作用发生在褶皱前碳酸盐陆源层状地层形成的早期阶段。以后,这些含金刚石侵入体与围岩一道遭受了异化学变质(混合岩化、花岗岩化和退变质),部分转变为新岩石———混合岩、片麻岩、角闪岩、片岩和退变岩,这些新岩石继承了石榴单辉岩及其它含金刚石母岩的金刚石部分。 展开更多
关键词 含金刚石 变质杂岩 多相性 异化学变质 地块
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含有多个恒功率负荷的多源直流微电网振荡抑制研究 被引量:20
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作者 李玉梅 査晓明 刘飞 《电力自动化设备》 EI CSCD 北大核心 2014年第3期40-46,共7页
分析了带恒功率负荷的级联系统在平衡点稳定的条件,以两源和两负荷级联系统耦合为例,通过求解耦合系统的特征值表明,2个参数相同的级联系统耦合不能提高其稳定性。探讨了抑制直流微电网振荡的2种策略:一种是通过引入源侧变换器参数的多... 分析了带恒功率负荷的级联系统在平衡点稳定的条件,以两源和两负荷级联系统耦合为例,通过求解耦合系统的特征值表明,2个参数相同的级联系统耦合不能提高其稳定性。探讨了抑制直流微电网振荡的2种策略:一种是通过引入源侧变换器参数的多相性并配合耦合控制参数的取值来抑制振荡;另一种是通过引入耦合控制的延迟量来消除振荡。仿真结果验证了2种策略的可行性和有效性。 展开更多
关键词 直流微电网 恒功率负荷 振荡 多相性 延迟耦合 稳定
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用N,N-二甲基六烷基溴化铵涂层的毛细管对重组促红细胞生长素及其酶解产物进行毛细管电泳和毛细管电泳-电喷雾质谱分析 被引量:2
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作者 于冰 丛海林 +2 位作者 刘虎威 李元宗 刘锋 《色谱》 CAS CSCD 北大核心 2005年第5期487-491,共5页
采用毛细管电泳技术研究了重组促红细胞生长素(rhEPO)的分离问题。用N,N-二甲基六烷基溴化铵(6,6-ionene)涂层的毛细管测定了rhEPO中唾液酸的微多相性,同时采用毛细管电泳-质谱(CE-M S)联用技术在22m in内鉴定了rhEPO20段胰酶消化肽中... 采用毛细管电泳技术研究了重组促红细胞生长素(rhEPO)的分离问题。用N,N-二甲基六烷基溴化铵(6,6-ionene)涂层的毛细管测定了rhEPO中唾液酸的微多相性,同时采用毛细管电泳-质谱(CE-M S)联用技术在22m in内鉴定了rhEPO20段胰酶消化肽中的11段。该方法简单快捷,重现性好,可用于蛋白质一级结构的测定。 展开更多
关键词 毛细管电泳 毛细管电泳-质谱联用 N N-二甲基六烷基溴化铵涂层 重组促红细胞生长素 酶解产物 多相性 肽图
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普适计算的个人智能环境应用开发
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作者 罗功宸 方志刚 《江南大学学报(自然科学版)》 CAS 2008年第1期21-25,共5页
从用户的角度出发,提出了"个人智能环境"的新概念以解决普适计算的多相性问题.并就其应用的可行性,通过系统功能、应用模型、界面一致性、数据流、安全性及命令集等方面的设计,在实验室的环境下建立和实现了一个EasyDay系统原型.
关键词 普适计算 多相性 个人智能环境 界面一致
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Design of similarity measure for discrete data and application to multi-dimension 被引量:1
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作者 LEE Myeong-ho 魏荷 +2 位作者 LEE Sang-hyuk LEE Sang-min SHIN Seung-soo 《Journal of Central South University》 SCIE EI CAS 2013年第4期982-987,共6页
Similarity measure design for discrete data group was proposed. Similarity measure design for continuous membership function was also carried out. Proposed similarity measures were designed based on fuzzy number and d... Similarity measure design for discrete data group was proposed. Similarity measure design for continuous membership function was also carried out. Proposed similarity measures were designed based on fuzzy number and distance measure, and were proved. To calculate the degree of similarity of discrete data, relative degree between data and total distribution was obtained. Discrete data similarity measure was completed with combination of mentioned relative degrees. Power interconnected system with multi characteristics was considered to apply discrete similarity measure. Naturally, similarity measure was extended to multi-dimensional similarity measure case, and applied to bus clustering problem. 展开更多
关键词 similarity measure MULTI-DIMENSION discrete data relative degree power interconnected system
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Modeling and monitoring of nonlinear multi-mode processes based on similarity measure-KPCA 被引量:10
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作者 WANG Xiao-gang HUANG Li-wei ZHANG Ying-wei 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第3期665-674,共10页
A new modeling and monitoring approach for multi-mode processes is proposed.The method of similarity measure(SM) and kernel principal component analysis(KPCA) are integrated to construct SM-KPCA monitoring scheme,wher... A new modeling and monitoring approach for multi-mode processes is proposed.The method of similarity measure(SM) and kernel principal component analysis(KPCA) are integrated to construct SM-KPCA monitoring scheme,where SM method serves as the separation of common subspace and specific subspace.Compared with the traditional methods,the main contributions of this work are:1) SM consisted of two measures of distance and angle to accommodate process characters.The different monitoring effect involves putting on the different weight,which would simplify the monitoring model structure and enhance its reliability and robustness.2) The proposed method can be used to find faults by the common space and judge which mode the fault belongs to by the specific subspace.Results of algorithm analysis and fault detection experiments indicate the validity and practicability of the presented method. 展开更多
关键词 process monitoring kernel principal component analysis (KPCA) similarity measure subspace separation
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Similarity measure design for high dimensional data 被引量:3
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作者 LEE Sang-hyuk YAN Sun +1 位作者 JEONG Yoon-su SHIN Seung-soo 《Journal of Central South University》 SCIE EI CAS 2014年第9期3534-3540,共7页
Information analysis of high dimensional data was carried out through similarity measure application. High dimensional data were considered as the a typical structure. Additionally, overlapped and non-overlapped data ... Information analysis of high dimensional data was carried out through similarity measure application. High dimensional data were considered as the a typical structure. Additionally, overlapped and non-overlapped data were introduced, and similarity measure analysis was also illustrated and compared with conventional similarity measure. As a result, overlapped data comparison was possible to present similarity with conventional similarity measure. Non-overlapped data similarity analysis provided the clue to solve the similarity of high dimensional data. Considering high dimensional data analysis was designed with consideration of neighborhoods information. Conservative and strict solutions were proposed. Proposed similarity measure was applied to express financial fraud among multi dimensional datasets. In illustrative example, financial fraud similarity with respect to age, gender, qualification and job was presented. And with the proposed similarity measure, high dimensional personal data were calculated to evaluate how similar to the financial fraud. Calculation results show that the actual fraud has rather high similarity measure compared to the average, from minimal 0.0609 to maximal 0.1667. 展开更多
关键词 high dimensional data similarity measure DIFFERENCE neighborhood information financial fraud
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Aerobic biodegradation of di-n-butyl phthalate by Xiangjiang River sediment and microflora analysis 被引量:3
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作者 周洪波 林峰 +4 位作者 胡培磊 金德才 任洪强 赵晶 邱冠周 《Journal of Central South University》 SCIE EI CAS 2009年第6期948-953,共6页
Di-n-butyl phthalate (DBP),one of phthalate acid esters (PAEs),was investigated to determine its biodegradation rate using Xiangjiang River sediment and find potential DBP degraders in the enrichment culture of the se... Di-n-butyl phthalate (DBP),one of phthalate acid esters (PAEs),was investigated to determine its biodegradation rate using Xiangjiang River sediment and find potential DBP degraders in the enrichment culture of the sediment. The sediment sample was incubated with an initial concentration of DBP of 100 mg/L for 5 d. The biodegradation rate of DBP was detected using HPLC and the degraded products were analyzed by GC/MS. Subsequently,the microbial diversity of the enrichment culture was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The results reveal that almost 100% of DBP is degraded after merely 3 d,generating two main degraded products:mono-butyl phthalate (MBP) and 9-octadecenoic acid. After a six-month enrichment period under the pressure of DBP,the dominant family in the final enrichment culture is clustered with the Comamonas sp.,the remaining are affiliated with Sphingomonas sp.,Hydrogenophaga sp.,Rhizobium sp.,and Acidovorax sp. The results show the potential of these bacteria to be used in the bioremediation of DBP in the environment. 展开更多
关键词 BIOREMEDIATION di-n-butyl phthalate SEDIMENT polymerase chain reaction-restriction fragment length polymorphism microbial diversity
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