The structureaffinity correlations of a series of benzamides for dopamine D 2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O 2 workstation.The results of conformational analysis and PM3 cal...The structureaffinity correlations of a series of benzamides for dopamine D 2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O 2 workstation.The results of conformational analysis and PM3 calculation have demonstrated that the coplanar effect of benzamides is one of the most important requirements for activity in vitro.The aromatic substituent in the 2 position is the main factor which influences the coplanar arrangement of pseudring (B) involving the amide moiety and the methoxy group relative to the aromatic ring,while the influences of other factors on this side such as the aromatic substituents in the 3 and 5 positions and the conformation of side chain may be neglected.The conclusion may be useful in understanding the interaction of D 2 receptorligand and designing new D 2 receptor ligands.展开更多
A novel dopamine D3 receptor imagining agent 7-OH-PFPAT(7-hydroxy-2-(N-propyl-N-3’-F-fluoropropionyl)aminotetralin)which has potential activity to be a dopamine D3 receptor is synthesized by multi-step reactions.At t...A novel dopamine D3 receptor imagining agent 7-OH-PFPAT(7-hydroxy-2-(N-propyl-N-3’-F-fluoropropionyl)aminotetralin)which has potential activity to be a dopamine D3 receptor is synthesized by multi-step reactions.At the same time,the precursor of dop-amine D3 receptor imagining agent(7-tetrahydropyranyl-2-(N-propyl-N-3’-bromopropionyl) aminotetralin) which can be radiolabeled with Fluorine-18 is prepared.The chemical structure of the target compound is confirmed by MS and 1H-NMR.This mild and easily manipulated synthetic procedure is attainable.These techniques may provide the potentiality to synthesize a radiolabeled compound 7-hydroxy-2-(N-propyl-N-3’-18F-fluoropropionyl) aminotetralin.展开更多
文摘The structureaffinity correlations of a series of benzamides for dopamine D 2 receptor imaging agents have been studied with SYBYL 6.4 software on SGI O 2 workstation.The results of conformational analysis and PM3 calculation have demonstrated that the coplanar effect of benzamides is one of the most important requirements for activity in vitro.The aromatic substituent in the 2 position is the main factor which influences the coplanar arrangement of pseudring (B) involving the amide moiety and the methoxy group relative to the aromatic ring,while the influences of other factors on this side such as the aromatic substituents in the 3 and 5 positions and the conformation of side chain may be neglected.The conclusion may be useful in understanding the interaction of D 2 receptorligand and designing new D 2 receptor ligands.
文摘A novel dopamine D3 receptor imagining agent 7-OH-PFPAT(7-hydroxy-2-(N-propyl-N-3’-F-fluoropropionyl)aminotetralin)which has potential activity to be a dopamine D3 receptor is synthesized by multi-step reactions.At the same time,the precursor of dop-amine D3 receptor imagining agent(7-tetrahydropyranyl-2-(N-propyl-N-3’-bromopropionyl) aminotetralin) which can be radiolabeled with Fluorine-18 is prepared.The chemical structure of the target compound is confirmed by MS and 1H-NMR.This mild and easily manipulated synthetic procedure is attainable.These techniques may provide the potentiality to synthesize a radiolabeled compound 7-hydroxy-2-(N-propyl-N-3’-18F-fluoropropionyl) aminotetralin.
