Systemic inflammatory response syndrome (SIRS) and its lethal sequela multiple organ dysfunction syndrome (MODS) are common complications in critical illness, such as severe trauma, shock, infection and major operatio...Systemic inflammatory response syndrome (SIRS) and its lethal sequela multiple organ dysfunction syndrome (MODS) are common complications in critical illness, such as severe trauma, shock, infection and major operations. During the past three decades, the evolution in our understanding of SIRS and/or MODS could be divided into three stages. Particularly in recent years, advances in molecular and cellular biology have provided new insights in the pathogenesis of this complex condition. The earlier emphasis on the pro inflammatory mediators involved in propagation of inflammatory response, has gradually been replaced by a realization that SIRS/MODS are the result of an imbalance of pro and anti inflammatory mediators to create the final status of excessive inflammation or immunoparalysis’. Though prognosis remains poor, the knowledge that now exists about SIRS/MODS gives great hope for the future. Progress has been made in new treatment modalities and re evaluation of current available measures. Nevertheless, improved techniques to monitor immunological or other markers of inflammatory and host defense responses will be important in assessing the effects of future therapies on central mechanisms contributing to SIRS/MODS.展开更多
多器官功能障碍综合征（multiple organ dysfunction syndrome，MODS）是指机体遭受严重创伤、休克、感染及外科大手术等急性损害24h后，同时或序贯性出现2个或2个以上的系统或器官功能障碍或衰竭，即多个器官功能改变不能维持内环境稳...多器官功能障碍综合征（multiple organ dysfunction syndrome，MODS）是指机体遭受严重创伤、休克、感染及外科大手术等急性损害24h后，同时或序贯性出现2个或2个以上的系统或器官功能障碍或衰竭，即多个器官功能改变不能维持内环境稳定的临床综合征；多器官衰竭（multiple organ failure，MOF）是MODS继续进展的最严重的终末期阶段。展开更多
文摘Systemic inflammatory response syndrome (SIRS) and its lethal sequela multiple organ dysfunction syndrome (MODS) are common complications in critical illness, such as severe trauma, shock, infection and major operations. During the past three decades, the evolution in our understanding of SIRS and/or MODS could be divided into three stages. Particularly in recent years, advances in molecular and cellular biology have provided new insights in the pathogenesis of this complex condition. The earlier emphasis on the pro inflammatory mediators involved in propagation of inflammatory response, has gradually been replaced by a realization that SIRS/MODS are the result of an imbalance of pro and anti inflammatory mediators to create the final status of excessive inflammation or immunoparalysis’. Though prognosis remains poor, the knowledge that now exists about SIRS/MODS gives great hope for the future. Progress has been made in new treatment modalities and re evaluation of current available measures. Nevertheless, improved techniques to monitor immunological or other markers of inflammatory and host defense responses will be important in assessing the effects of future therapies on central mechanisms contributing to SIRS/MODS.
文摘多器官功能障碍综合征（multiple organ dysfunction syndrome，MODS）是指机体遭受严重创伤、休克、感染及外科大手术等急性损害24h后，同时或序贯性出现2个或2个以上的系统或器官功能障碍或衰竭，即多个器官功能改变不能维持内环境稳定的临床综合征；多器官衰竭（multiple organ failure，MOF）是MODS继续进展的最严重的终末期阶段。
