Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investg...Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.展开更多
Kinetic resolution of(R,S)-2-methyl-1-butanol was completed by porcine pancreatic lipase-catalyzed transesterification with triacetin in a solvent-free system.The effect of reaction conditions such as solvents,water,p...Kinetic resolution of(R,S)-2-methyl-1-butanol was completed by porcine pancreatic lipase-catalyzed transesterification with triacetin in a solvent-free system.The effect of reaction conditions such as solvents,water,pH,temperature,and the molar ratio of the substrates on lipase activity and stereoselectivity were examined.The results demonstrate triacetin has an advantage of low price and high activity when it is employed as the substrate in the kinetic resolution of(R,S)-2-mentyl-1-butanol and is a very promising tributyrin substitute for industrial application.展开更多
文摘Catalyzed Resolutionb racemic 2-methyl-1-butanol was achieved,with max.95%optical purity of chiral alcohol,by candida cycindrace lipase in non-aqueous organic media.Effect of some factors on the resolution was investgated.The factors included temperature,pH,organic solvents,the amount of added water and the reaction time.
文摘Kinetic resolution of(R,S)-2-methyl-1-butanol was completed by porcine pancreatic lipase-catalyzed transesterification with triacetin in a solvent-free system.The effect of reaction conditions such as solvents,water,pH,temperature,and the molar ratio of the substrates on lipase activity and stereoselectivity were examined.The results demonstrate triacetin has an advantage of low price and high activity when it is employed as the substrate in the kinetic resolution of(R,S)-2-mentyl-1-butanol and is a very promising tributyrin substitute for industrial application.
