While doing more thorough and delicate in-vestigation on already known cytokines, scien-tists have always been searching numerousphenomena and facts for novel factors. Thus,several years ago interleukin-12 (IL-12) cam...While doing more thorough and delicate in-vestigation on already known cytokines, scien-tists have always been searching numerousphenomena and facts for novel factors. Thus,several years ago interleukin-12 (IL-12) cameinto our sight. In 1986, Gately et al in the Hoffmann-La Roche Inc. noted that in the mixedlymphocyte culture supernatants there existed afactor that could synergize with IL-2 in en-hancing the cytotoxicity of cytotoxic Tlymphocytes (CTL). Wong et al confirmed in1988 the existence of a new factor distinguishedfrom any other known factors. Stern et展开更多
文摘While doing more thorough and delicate in-vestigation on already known cytokines, scien-tists have always been searching numerousphenomena and facts for novel factors. Thus,several years ago interleukin-12 (IL-12) cameinto our sight. In 1986, Gately et al in the Hoffmann-La Roche Inc. noted that in the mixedlymphocyte culture supernatants there existed afactor that could synergize with IL-2 in en-hancing the cytotoxicity of cytotoxic Tlymphocytes (CTL). Wong et al confirmed in1988 the existence of a new factor distinguishedfrom any other known factors. Stern et
