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生物制药生产中的在线产量预测及经济效益优化 被引量:3
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作者 袁景淇 金雪娟 沈云岐 《中国抗生素杂志》 CAS CSCD 北大核心 1999年第3期161-168,共8页
针对生物发酵生产波动大、大量经典优化控制手段难以奏效的特点,本文从建立过程的经济效益函数入手,提出了一种将在线动态优化和稳态调度优化相结合的总体优化方案。效益函数由物料、能量衡算获得,它集产率、得率及产品质量指标于一... 针对生物发酵生产波动大、大量经典优化控制手段难以奏效的特点,本文从建立过程的经济效益函数入手,提出了一种将在线动态优化和稳态调度优化相结合的总体优化方案。效益函数由物料、能量衡算获得,它集产率、得率及产品质量指标于一体,是各罐批创利状况的客观评价函数。效益优化的前提之一是产量预测,故文中叙述了进行在线产量预测的两个方法,即基于模型的和基于人工神经网络的方法。前者采用滚动参数辨识技术,利用现有模型对过程进行短期预测,后者则是适用于一般过程的滚动学习-预测。关于动态效益优化,本文给出了设计思想并基于头孢菌素C参数自适应模型给出了一个实例。关于人工神经网络,本文结合青霉素发酵生产,证实了神经网络预估器在发酵中、后期的高预测精度和强鲁棒性。这使后继工作,即基于效益函数的统计分析和预测进行稳态调度优化和异常罐批早期诊断等,得以展开。 展开更多
关键词 效益函数 生物制药 在线产量 经济效益 优化
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On-line forecasting model for zinc output based on self-tuning support vector regression and its application
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作者 胡志坤 桂卫华 彭小奇 《Journal of Central South University of Technology》 2004年第4期461-464,共4页
An on-line forecasting model based on self-tuning support vectors regression for zinc output was put forward to maximize zinc output by adjusting operational parameters in the process of imperial smelting furnace. In ... An on-line forecasting model based on self-tuning support vectors regression for zinc output was put forward to maximize zinc output by adjusting operational parameters in the process of imperial smelting furnace. In this model, the mathematical model of support vector regression was converted into the same format as support vector machine for classification. Then a simplified sequential minimal optimization for classification was applied to train the regression coefficient vector α- α* and threshold b. Sequentially penalty parameter C was tuned dynamically through forecasting result during the training process. Finally, an on-line forecasting algorithm for zinc output was proposed. The simulation result shows that in spite of a relatively small industrial data set, the effective error is less than 10% with a remarkable performance of real time. The model was applied to the optimization operation and fault diagnosis system for imperial smelting furnace. 展开更多
关键词 imperial smelting furnace support vectors regression sequential minimal optimization zinc output on-line forecasting
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