By combining 2 chloropyridine, 1,3,4 thiadiazole and acylamide, three toxophoric moieties seven 2 [ N (1 methoxycarbonyl)ethyl N acyl]amino 5 [(2 chloropyrid) 4 yl] 1,3,4 thiadiazoles(8) were synthesized in seven step...By combining 2 chloropyridine, 1,3,4 thiadiazole and acylamide, three toxophoric moieties seven 2 [ N (1 methoxycarbonyl)ethyl N acyl]amino 5 [(2 chloropyrid) 4 yl] 1,3,4 thiadiazoles(8) were synthesized in seven steps. The preliminary biological activity tests show that the title compounds reveal a certain plant growth regulating effect as well as fungicidal activity.展开更多
Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reac...Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reach 82%,and then chlorination with phosphorus oxychloride resulted in 2-amino-4-chloro-6-trifluoromethylpyrimidine,which,upon reaction with nucleophiles,gave hight yields of the corresponding 2-aminopyrimidines derivatives.Mass spectra show that outgrowth of chlorination is 2-amino-4-（2-amino-6-trifluoromethyl-4-chloro）-6-trifluoromethy1 pyirmidine.The structures were characterized by IR,MS and （）1H NMR spectra.展开更多
为了寻找干扰嘌呤核酸代谢的抗肿瘤新药,设计和合成了嘌呤生物碱的类似物。以2-氨基-1,3,4-噻二唑、丙二酸与三氯氧磷为原料,经过关环,偶合等反应合成了9种5-羟基-1,3,4-噻二唑[3,2-a]并嘧啶-7-酮衍生物,通过元素分析、IR、1 H NMR和质...为了寻找干扰嘌呤核酸代谢的抗肿瘤新药,设计和合成了嘌呤生物碱的类似物。以2-氨基-1,3,4-噻二唑、丙二酸与三氯氧磷为原料,经过关环,偶合等反应合成了9种5-羟基-1,3,4-噻二唑[3,2-a]并嘧啶-7-酮衍生物,通过元素分析、IR、1 H NMR和质谱分析确定了其结构。展开更多
dihydropyrimidinones derivatives were synthesized in high yields by one pot three component Biginelli condensation from aldehyde, β keto ester and urea in ethanol,while cobalt chloride hexahydrate was used as a catal...dihydropyrimidinones derivatives were synthesized in high yields by one pot three component Biginelli condensation from aldehyde, β keto ester and urea in ethanol,while cobalt chloride hexahydrate was used as a catalyst.This modified Biginellis reaction not only makes the reaction period short,the operation simple,but also gives high yields.展开更多
文摘By combining 2 chloropyridine, 1,3,4 thiadiazole and acylamide, three toxophoric moieties seven 2 [ N (1 methoxycarbonyl)ethyl N acyl]amino 5 [(2 chloropyrid) 4 yl] 1,3,4 thiadiazoles(8) were synthesized in seven steps. The preliminary biological activity tests show that the title compounds reveal a certain plant growth regulating effect as well as fungicidal activity.
文摘Synthesis and characterization of 2-amino-6-trifluoromethylpyrimidine derivatives were reported in this paper.Condensation of guanidine hydrochloride with ethy1-4,4,4-triflu oroacetoacetate,in which the yield can reach 82%,and then chlorination with phosphorus oxychloride resulted in 2-amino-4-chloro-6-trifluoromethylpyrimidine,which,upon reaction with nucleophiles,gave hight yields of the corresponding 2-aminopyrimidines derivatives.Mass spectra show that outgrowth of chlorination is 2-amino-4-（2-amino-6-trifluoromethyl-4-chloro）-6-trifluoromethy1 pyirmidine.The structures were characterized by IR,MS and （）1H NMR spectra.
文摘dihydropyrimidinones derivatives were synthesized in high yields by one pot three component Biginelli condensation from aldehyde, β keto ester and urea in ethanol,while cobalt chloride hexahydrate was used as a catalyst.This modified Biginellis reaction not only makes the reaction period short,the operation simple,but also gives high yields.
