Fourteen unreported 2-amino-4H-imidazol-4-ones 4 were rapidly synthesized by a new parallel synthetic method, which included aza-Wittig reaction of iminophosphorane 1 with phenyl isocynate to give carbodiimide 2 and s...Fourteen unreported 2-amino-4H-imidazol-4-ones 4 were rapidly synthesized by a new parallel synthetic method, which included aza-Wittig reaction of iminophosphorane 1 with phenyl isocynate to give carbodiimide 2 and subsequent reaction of 2 with various amines in a parallel fashion. The structure of compound 4 was confirmed by means of 1H NMR, MS and IR. The configuration of compound 4b was determined as in Z form since the coupling constant 3J( 13C, 1H) between the carbonyl carbon and the olefinic hydrogen was 5.6 Hz.展开更多
文摘Fourteen unreported 2-amino-4H-imidazol-4-ones 4 were rapidly synthesized by a new parallel synthetic method, which included aza-Wittig reaction of iminophosphorane 1 with phenyl isocynate to give carbodiimide 2 and subsequent reaction of 2 with various amines in a parallel fashion. The structure of compound 4 was confirmed by means of 1H NMR, MS and IR. The configuration of compound 4b was determined as in Z form since the coupling constant 3J( 13C, 1H) between the carbonyl carbon and the olefinic hydrogen was 5.6 Hz.
