N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to b...N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to be the best.Their structures were confirmed by fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance spectrum(HNMR).展开更多
The title complex nBuSn(O)(tsglyO)6·6CHCl3 (tsglyO=N-p-tolysulfonyl-glycinate monoanion) was syn- thesized by the reaction of nBuSn(O)OH with N-p-tolysulfonyl-glycine in 1∶1 molar ratio. The complex was charac- ...The title complex nBuSn(O)(tsglyO)6·6CHCl3 (tsglyO=N-p-tolysulfonyl-glycinate monoanion) was syn- thesized by the reaction of nBuSn(O)OH with N-p-tolysulfonyl-glycine in 1∶1 molar ratio. The complex was charac- terized by IR, 1H NMR spectra and elemental analysis. The crystal structure was determined by X-ray diffraction method. It crystallizes in rhombohedral system with space group R3. The crystal data are: a=b=2.7387(4) nm, c= 1.4465(4) nm, α=β=90°, γ=120°, Z=6, Dc=1.726 g·cm-3, F(000)=4878, V=9.396(3) nm3, R1=0.0325, wR2=0.089 8. The structure shows a distorted octahedral configuration with six-coordination for the central tin atom. CCDC: 274183.展开更多
Gly\| L His L Lys(GHK) was synthesized by liquid\|phase method. The HPLC analysis indicated that the proteolysis of GHK was initiated at the N terminal in liver homogenate. The result suggested that GHK was rapidly de...Gly\| L His L Lys(GHK) was synthesized by liquid\|phase method. The HPLC analysis indicated that the proteolysis of GHK was initiated at the N terminal in liver homogenate. The result suggested that GHK was rapidly degraded by aminopeptidases in liver.展开更多
文摘N-glycinylmaleamic acid(GMA) was synthesized by using maleic anhydride and glycine.Five synthesis methods for N-glycinylmaleimide(GMI)were compared.Among them the method using triethylamine to dehydrate was found to be the best.Their structures were confirmed by fourier transform infrared spectroscopy(FTIR) and nuclear magnetic resonance spectrum(HNMR).
文摘The title complex nBuSn(O)(tsglyO)6·6CHCl3 (tsglyO=N-p-tolysulfonyl-glycinate monoanion) was syn- thesized by the reaction of nBuSn(O)OH with N-p-tolysulfonyl-glycine in 1∶1 molar ratio. The complex was charac- terized by IR, 1H NMR spectra and elemental analysis. The crystal structure was determined by X-ray diffraction method. It crystallizes in rhombohedral system with space group R3. The crystal data are: a=b=2.7387(4) nm, c= 1.4465(4) nm, α=β=90°, γ=120°, Z=6, Dc=1.726 g·cm-3, F(000)=4878, V=9.396(3) nm3, R1=0.0325, wR2=0.089 8. The structure shows a distorted octahedral configuration with six-coordination for the central tin atom. CCDC: 274183.
文摘Gly\| L His L Lys(GHK) was synthesized by liquid\|phase method. The HPLC analysis indicated that the proteolysis of GHK was initiated at the N terminal in liver homogenate. The result suggested that GHK was rapidly degraded by aminopeptidases in liver.
