Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primari...Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primarily focuses on identifying the maximum tolerated dose(MTD),therapies involving targeted and immune agents facilitate the identifica-tion of an optimal biological dose combination(OBDC)by simultaneously evaluating both toxicity and efficacy.Cur-rently,most approaches to determining the OBDC in the literature are model-based and require complex model fittings,making them cumbersome and challenging to implement.To address these challenges,we developed a novel model-as-sisted approach called uTPI-Comb.This approach refines the established utility-based toxicity probability interval design by integrating a strategically devised zone-based local and global candidate set searching strategy,which can effectively optimize the decision-making process for two-agent dose escalation or de-escalation in drug combination trials.Extensive simulation studies demonstrate that the uTPI-Comb design speeds up the dose-searching process and provides substantial improvements over existing model-based methods in determining the optimal biological dose combinations.展开更多
An element coupling model (ECM) method was proposed to simulate the global behavior and local damage of a structure.In order to reflect the local damage and improve the computational efficiency,three-dimensional (3D) ...An element coupling model (ECM) method was proposed to simulate the global behavior and local damage of a structure.In order to reflect the local damage and improve the computational efficiency,three-dimensional (3D) solid elements and one-dimensional (1D) beam element were coupled by the multi-point constraint equations.A reduced scale 1?8 model test was simulated by the ECM and a full three dimensional model (3DM) contrastively.The results show that the global behavior and local damages of ECM agree well with the test and 3DM.It is indicated that the proposed method can be used in the structural nonlinear analysis accurately and efficiently.展开更多
An explicit congestion notification (ECN)-based distributed transport protocol,ARROW-WTCP (AcceleRate tRansmission towards Optimal Window size TCP for Wireless network),was proposed.The ARROW-WTCP enables feasible dep...An explicit congestion notification (ECN)-based distributed transport protocol,ARROW-WTCP (AcceleRate tRansmission towards Optimal Window size TCP for Wireless network),was proposed.The ARROW-WTCP enables feasible deployment of ARROW-TCP from wired to wireless networks by providing a joint design of source and router algorithms.The protocol obtains the actual capacity of the wireless channel by calculating the queue variation in base station (BS) and adjusts the congestion window by using the feedback from its bottleneck link.The simulation results show that the ARROW-WTCP achieves strong stability,max-min fairness in dynamic networks,fast convergence to efficiency without introducing much excess traffic,and almost full link utilization in the steady state.It outperforms the XCP-B (eXplicit Control Protocol Blind),the wireless version of XCP,in terms of stability,fairness,convergence and utilization in wireless networks.展开更多
In this work, power efficient butterfly unit based FFT architecture is presented. The butterfly unit is designed using floating-point fused arithmetic units. The fused arithmetic units include two-term dot product uni...In this work, power efficient butterfly unit based FFT architecture is presented. The butterfly unit is designed using floating-point fused arithmetic units. The fused arithmetic units include two-term dot product unit and add-subtract unit. In these arithmetic units, operations are performed over complex data values. A modified fused floating-point two-term dot product and an enhanced model for the Radix-4 FFT butterfly unit are proposed. The modified fused two-term dot product is designed using Radix-16 booth multiplier. Radix-16 booth multiplier will reduce the switching activities compared to Radix-8 booth multiplier in existing system and also will reduce the area required. The proposed architecture is implemented efficiently for Radix-4 decimation in time(DIT) FFT butterfly with the two floating-point fused arithmetic units. The proposed enhanced architecture is synthesized, implemented, placed and routed on a FPGA device using Xilinx ISE tool. It is observed that the Radix-4 DIT fused floating-point FFT butterfly requires 50.17% less space and 12.16% reduced power compared to the existing methods and the proposed enhanced model requires 49.82% less space on the FPGA device compared to the proposed design. Also, reduced power consumption is addressed by utilizing the reusability technique, which results in 11.42% of power reduction of the enhanced model compared to the proposed design.展开更多
基金This work was supported by the Natural Science Foundation of Anhui Province(2022AH050703)the National Natural Science Foundation of China(11671375).
文摘Finding the optimal dose combination in two-agent dose-finding trials is challenging due to limited sample sizes and the extensive range of potential doses.Unlike traditional chemotherapy or radiotherapy,which primarily focuses on identifying the maximum tolerated dose(MTD),therapies involving targeted and immune agents facilitate the identifica-tion of an optimal biological dose combination(OBDC)by simultaneously evaluating both toxicity and efficacy.Cur-rently,most approaches to determining the OBDC in the literature are model-based and require complex model fittings,making them cumbersome and challenging to implement.To address these challenges,we developed a novel model-as-sisted approach called uTPI-Comb.This approach refines the established utility-based toxicity probability interval design by integrating a strategically devised zone-based local and global candidate set searching strategy,which can effectively optimize the decision-making process for two-agent dose escalation or de-escalation in drug combination trials.Extensive simulation studies demonstrate that the uTPI-Comb design speeds up the dose-searching process and provides substantial improvements over existing model-based methods in determining the optimal biological dose combinations.
基金Project(2007CB714202) supported by the National Key Basic Research Program of ChinaProject(SLDRCE10-B-07) supported by theMinistry of Science and Technology of China
文摘An element coupling model (ECM) method was proposed to simulate the global behavior and local damage of a structure.In order to reflect the local damage and improve the computational efficiency,three-dimensional (3D) solid elements and one-dimensional (1D) beam element were coupled by the multi-point constraint equations.A reduced scale 1?8 model test was simulated by the ECM and a full three dimensional model (3DM) contrastively.The results show that the global behavior and local damages of ECM agree well with the test and 3DM.It is indicated that the proposed method can be used in the structural nonlinear analysis accurately and efficiently.
基金Projects(60873265,60903222) supported by the National Natural Science Foundation of China Project(IRT0661) supported by the Program for Changjiang Scholars and Innovative Research Team in University of China
文摘An explicit congestion notification (ECN)-based distributed transport protocol,ARROW-WTCP (AcceleRate tRansmission towards Optimal Window size TCP for Wireless network),was proposed.The ARROW-WTCP enables feasible deployment of ARROW-TCP from wired to wireless networks by providing a joint design of source and router algorithms.The protocol obtains the actual capacity of the wireless channel by calculating the queue variation in base station (BS) and adjusts the congestion window by using the feedback from its bottleneck link.The simulation results show that the ARROW-WTCP achieves strong stability,max-min fairness in dynamic networks,fast convergence to efficiency without introducing much excess traffic,and almost full link utilization in the steady state.It outperforms the XCP-B (eXplicit Control Protocol Blind),the wireless version of XCP,in terms of stability,fairness,convergence and utilization in wireless networks.
文摘In this work, power efficient butterfly unit based FFT architecture is presented. The butterfly unit is designed using floating-point fused arithmetic units. The fused arithmetic units include two-term dot product unit and add-subtract unit. In these arithmetic units, operations are performed over complex data values. A modified fused floating-point two-term dot product and an enhanced model for the Radix-4 FFT butterfly unit are proposed. The modified fused two-term dot product is designed using Radix-16 booth multiplier. Radix-16 booth multiplier will reduce the switching activities compared to Radix-8 booth multiplier in existing system and also will reduce the area required. The proposed architecture is implemented efficiently for Radix-4 decimation in time(DIT) FFT butterfly with the two floating-point fused arithmetic units. The proposed enhanced architecture is synthesized, implemented, placed and routed on a FPGA device using Xilinx ISE tool. It is observed that the Radix-4 DIT fused floating-point FFT butterfly requires 50.17% less space and 12.16% reduced power compared to the existing methods and the proposed enhanced model requires 49.82% less space on the FPGA device compared to the proposed design. Also, reduced power consumption is addressed by utilizing the reusability technique, which results in 11.42% of power reduction of the enhanced model compared to the proposed design.
