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卡那霉素鉴别抗虫杂交棉F_2的生产应用研究
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作者 凌士鹏 方康书 +2 位作者 章志兴 包立生 鲍艳红 《浙江农业科学》 2006年第1期70-72,共3页
通过对抗虫杂交棉慈抗杂3号和湘杂棉3号的F1(A1、B1)、F2(A2、B2)和应用硫酸卡那霉素在苗床期鉴别并剔除非抗虫株的F2(A3、B3)等6个处理,进行重复对比试验,结果表明F1抗虫杂交棉在皮棉产量、群体抗虫性、生长整齐度等方面比F2表现出明... 通过对抗虫杂交棉慈抗杂3号和湘杂棉3号的F1(A1、B1)、F2(A2、B2)和应用硫酸卡那霉素在苗床期鉴别并剔除非抗虫株的F2(A3、B3)等6个处理,进行重复对比试验,结果表明F1抗虫杂交棉在皮棉产量、群体抗虫性、生长整齐度等方面比F2表现出明显优势,其中皮棉产量增产10%以上,但F2与F1在皮棉品质上无明显差别。应用硫酸卡那霉素在苗床期鉴别并剔除非抗虫株的F2比未经处理的F2在皮棉产量、群体抗虫性、主要经济性状等方面有所改善,但品种间的提高程度有所不同。该方法为抗虫杂交棉F2在生产上的应用提供了新途径,具有一定应用价值。 展开更多
关键词 抗虫杂交棉F2 那霉 鉴别
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双特异性抗体药物在肿瘤治疗领域的研究进展 被引量:6
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作者 岳雅丽 尹骏 +1 位作者 高向东 姚文兵 《中国药科大学学报》 CAS CSCD 北大核心 2019年第3期289-298,共10页
肿瘤免疫疗法是目前治疗肿瘤的新方向。双特异性抗体可结合两种不同的抗原,因而在肿瘤治疗领域的开发前景十分广阔。双特异性抗体中最引人注目的三功能抗体和双特异性T细胞衔接抗体已分别有药物上市,代表药物是卡妥索单抗和博纳吐单抗... 肿瘤免疫疗法是目前治疗肿瘤的新方向。双特异性抗体可结合两种不同的抗原,因而在肿瘤治疗领域的开发前景十分广阔。双特异性抗体中最引人注目的三功能抗体和双特异性T细胞衔接抗体已分别有药物上市,代表药物是卡妥索单抗和博纳吐单抗。迄今为止,有将近100种抗肿瘤的双特异性抗体药物正在进行临床研究,深入理解它们的作用机制将为肿瘤治疗提供更多可行的方案。本文对卡妥索单抗、博纳吐单抗和目前极具开发前景的双特异性抗体药物的研究进展进行综述,以期为在肿瘤治疗领域的开发与应用奠定基础。 展开更多
关键词 双特异性抗体 抗肿瘤 单抗 博纳吐单抗 进展
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双特异性抗体的免疫原性 被引量:1
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作者 陈敏 方翼 《中国临床药理学与治疗学》 CAS CSCD 2021年第10期1208-1212,共5页
双特异性抗体能够识别并结合两种不同抗原的抗体,与普通抗体药物相比具有灵敏度高、特异性强、以及能够同时阻断多条疾病通路的优势。迄今为止,全球共有3款双特异性抗体药物已上市,近100种双特异性抗体在研,展现出广阔的开发前景。双特... 双特异性抗体能够识别并结合两种不同抗原的抗体,与普通抗体药物相比具有灵敏度高、特异性强、以及能够同时阻断多条疾病通路的优势。迄今为止,全球共有3款双特异性抗体药物已上市,近100种双特异性抗体在研,展现出广阔的开发前景。双特异性抗体药物的免疫原性指其进入体内后会引起机体免疫反应产生抗药抗体,可能对药物的药代动力学、药效动力学性质产生影响。本文对卡妥索单抗(catumaxomab)、博纳吐单抗(blinatumomab)、艾美赛珠单抗(emicizumab)的免疫原性相关研究进展进行综述,以期为双特异性抗体的安全性、有效性以及临床合理应用提供参考。 展开更多
关键词 双特异性抗体 单抗 博纳吐单抗 艾美赛珠单抗 免疫原性
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Fuzzy neural and chaotic searching hybrid algorithm and its application in electric customers’s credit risk evaluation 被引量:2
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作者 李翔 刘广迎 乞建勋 《Journal of Central South University of Technology》 EI 2007年第1期140-143,共4页
To evaluate the credit risk of customers in power market precisely, the new chaotic searching and fuzzy neural network (FNN) hybrid algorithm were proposed. By combining with the chaotic searching, the learning abilit... To evaluate the credit risk of customers in power market precisely, the new chaotic searching and fuzzy neural network (FNN) hybrid algorithm were proposed. By combining with the chaotic searching, the learning ability of the FNN was markedly enhanced. Customers’ actual credit flaw data of power supply enterprises were collected to carry on the real evaluation, which can be treated as example for the model. The result shows that the proposed method surpasses the traditional statistical models in regard to the precision of forecasting and has a practical value. Compared with the results of ordinary FNN and ANN, the precision of the proposed algorithm can be enhanced by 2.2% and 4.5%, respectively. 展开更多
关键词 power supply enterprise credit-risk fuzzy neural network chaotic searching
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Probability calculation of rebars corrosion in reinforced concrete using css algorithms 被引量:3
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作者 Mohsen-Ali Shayanfar Mohammad-Ali Barkhordari Mohammad Ghanooni-Bagha 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第8期3141-3150,共10页
Reinforcement inside the concrete is protected from corrosion and its damages until several years after the construction. After corrosion initiation, the cross section of reinforcement begins to reduce and often load ... Reinforcement inside the concrete is protected from corrosion and its damages until several years after the construction. After corrosion initiation, the cross section of reinforcement begins to reduce and often load bearing of the reinforced concrete structure will be reduced significantly. Corrosion of reinforcements in concrete in polluted and contaminated areas can occur in two ways: chloride and carbonation. In this work, meta-heuristic approach of charged system search(CSS) is used to calculate corrosion occurrence probability due to chloride ions penetration. The model efficiency is verified by comparing the available examples in technical literature and results of Monte Carlo analysis. According to the analyses performed, using different probabilistic distributions regardless of probabilistic moments based on real distribution leads to diverse results. In addition, influence of each effective parameter in corrosion occurrence varies by changing other parameters. 展开更多
关键词 reinforced concrete reliability index chloride diffusion CARBONATION charged system search (CSS) optimization
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